Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis

Molecular Immunology

Volumn 42, Issue 7, 2005, Pages 821-831

  Sato, Shinichi ^a   Fujimoto, Manabu ^b   Hasegawa, Minoru ^a   Takehara, Kazuhiko ^a   Tedder, Thomas F ^c  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

B lymphocyte; CD19; Signaling; Systemic autoimmunity; Systemic sclerosis

Indexed keywords

CD19 ANTIGEN; INTERLEUKIN 6;

ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CONFERENCE PAPER; CONNECTIVE TISSUE DISEASE; CYTOKINE PRODUCTION; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; MEMORY CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN FIBROSIS; SYSTEMIC SCLEROSIS; TRANSGENIC MOUSE;

EID: 16844376253     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2005.01.009     Document Type: Conference Paper

References (99)

1. K. Agematsu CD27: a memory B-cell marker Immunol. Today 21 2000 204 206
2. E. Arce Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus J. Immunol. 167 2001 2361 2369
3. F.C. Arnett Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts Arthritis Rheum. 44 2001 1359 1362
4. N. Asano B lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse Am. J. Pathol. 165 2004 641 650
5. J.O. Bohnhorst Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome J. Immunol. 167 2001 3610 3618
6. S. Bolland, and J.V. Ravetch Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis Immunity 13 2000 277 285
7. C. Bona, and N. Rothfield Autoantibodies in scleroderma and tightskin mice Curr. Opin. Immunol. 6 1994 931 937
8. A.M. Buhl, and J.C. Cambier Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase J. Immunol. 162 1999 4438 4446
9. 2+ mobilization J. Exp. Med. 186 1997 1897 1910
10. O.T. Chan A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus J. Exp. Med. 189 1999 1639 1648
11. R.J. Cornall The regulation of self-reactive B cells Curr. Opin. Immunol. 7 1995 804 811
12. J.G. Cyster, and C.C. Goodnow Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection Immunity 2 1995 13 24
13. S. De Vita Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of B cells Arthritis Rheum. 46 2002 2029 2033
14. M.R. Duncan, and B. Berman Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6 J. Invest. Dermatol. 97 1991 686 692
15. J.C. Edwards, and G. Cambridge Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes Rheumatology (Oxford) 40 2001 205 211
16. P. Engel Abnormal B lymphocyte development, activation and differentiation in mice that lack or overexpress the CD19 signal transduction molecule Immunity 3 1995 39 50
17. G. Famularo Polyclonal B lymphocyte activation in progressive systemic sclerosis J. Clin. Lab. Immunol. 29 1989 59 63
18. R. Fleischmajer Cellular infiltrates in scleroderma skin Arthritis Rheum. 20 1977 975 984
19. M. Fujimoto Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop Immunity 11 1999 191 200
20. M. Fujimoto CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation J. Immunol. 162 1999 7088 7094
21. M. Fujimoto CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification Immunity 13 2000 47 57
22. M. Fujimoto CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification Immunol. Res. 22 2000 281 298
23. M. Fujimoto Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction J. Immunol. 168 2002 5465 5476
24. D.E. Furst, and P.J. Clements Hypothesis for the pathogenesis of systemic sclerosis J. Rheumatol. 24 Suppl. 48 1997 53 57
25. B. Gayraud New insights into the assembly of extracellular microfibrils from the analysis of the fibrillin 1 mutation in the tight skin mouse J. Cell Biol. 150 2000 667 680
26. C.C. Goodnow Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires Proc. Natl. Acad. Sci. U.S.A. 93 1996 2264 2271
27. M.C. Green Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton Am. J. Pathol. 82 1976 493 512
28. A. Hansen Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome Arthritis Rheum. 46 2002 2160 2171
29. M. Hasegawa Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis J. Rheumatol. 25 1998 308 313
30. M. Hasegawa Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis Rheumatology 38 1999 612 617
31. P. Hasler, and M. Zouali B cell receptor signaling and autoimmunity FASEB J. 15 2001 2085 2098
32. M.L. Hibbs Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity J. Exp. Med. 196 2002 1593 1604
33. M. Inaoki CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes J. Exp. Med. 186 1997 1923 1931
34. A.M. Jacobi Correlation between circulating CD27 high plasma cells and disease activity in patients with systemic lupus erythematosus Arthritis Rheum. 48 2003 1332 1342
35. S.A. Jimenez Pathogenesis of scleroderma: collagen Rheum. Dis. Clin. N. Am. 22 1996 647 674
36. K.N. Kasturi B-cell deficiency does not abrogate development of cutaneous hyperplasia in mice inheriting the defective fibrillin-1 gene J. Autoimmun. 10 1997 505 517
37. Y. Kawaguchi Endogenous IL-1a from systemic sclerosis fibroblasts induces IL-6 and PDGF-A J. Clin. Invest. 103 1999 1253 1260
38. C.M. Kielty The tight skin mouse: demonstration of mutant fibrillin-1 production and assembly into abnormal microfibrils J. Cell Biol. 140 1998 1159 1166
39. T. Kishimoto The biology of interleukin-6 Blood 74 1989 1 10
40. A.S. Korganow From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins Immunity 10 1999 451 461
41. M. Koscec Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture J. Immunol. 159 1997 2033 2041
42. V. Kouskoff Organ-specific disease provoked by systemic autoimmunity Cell 87 1996 811 822
43. M. Kuwana Longitudinal analysis of autoantibody response to topoisomerase I in systemic sclerosis Arthritis Rheum. 43 2000 1074 1084
44. S. Latour, and A. Veillette Proximal protein tyrosine kinases in immunoreceptor signalling Curr. Opin. Immunol. 13 2001 299 306
45. M.J. Leandro An open study of B lymphocyte depletion in systemic lupus erythematosus Arthritis Rheum. 46 2002 2673 2677
46. E.C. LeRoy Scleroderma (systemic sclerosis): classification, subsets, and pathogenesis J. Rheumatol. 15 1988 202 205
47. S.-N.C. Liossis B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events J. Clin. Invest. 98 1996 2549 2557
48. P.E. Lipsky Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity Nat. Immunol. 2 2001 764 766
49. Q. Liu The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signalling J. Exp. Med. 188 1998 1333 1342
50. X. Liu A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodelling J. Cell Biol. 130 1995 227 237
51. R. Majeti An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity Cell 103 2000 1059 1070
52. I. Matsumoto Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders Arthritis Rheum. 48 2003 944 954
53. I. Matsumoto How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease Nat. Immunol. 3 2002 360 365
54. I. Matsumoto Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme Science 286 1999 1732 1735
55. M.D. Mayes Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population Arthritis Rheum. 48 2003 2246 2255
56. P.A. McSweeney High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes Blood 100 2002 1602 1610
57. J.P. Mitchell Engagement of complement receptor 2 on the surface of B cells from patients with systemic lupus erythematosus contributes to the increased responsiveness to antigen stimulation Lupus 11 2002 299 303
58. C. Murai Spontaneous occurrence of anti-fibrillin-1 autoantibodies in tight-skin mice Autoimmunity 28 1998 151 155
59. H. Nagase, and J.F. Woessner Jr. Matrix metalloproteinases J. Biol. Chem. 274 1999 21491 21494
60. H. Nishizumi Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice Immunity 3 1995 549 560
61. T.L. O'Keefe Hyperresponsive B cells in CD22-deficient mice Science 274 1996 798 801
62. L.M. O'Rourke CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav Immunity 8 1998 635 645
63. M. Odendahl Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus J. Immunol. 165 2000 5970 5979
64. Y. Okano Antinuclear antibody in systemic sclerosis (scleroderma) Rheum. Dis. Clin. N. Am. 22 1996 709 735
65. C.J. Painter Specificities and V genes encoding monoclonal antoantibodies from viable motheaten mice J. Exp. Med. 167 1988 1137 1153
66. C. Pan CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation Immunity 11 1999 495 506
67. G. Pani The motheaten mutation rescues B cell signaling and development in CD45-deficient mice J. Exp. Med. 186 1997 581 588
68. D.D. Patel B cell-ablative therapy for the treatment of autoimmune diseases Arthritis Rheum. 46 2002 1984 1985
69. R.C. Rickert Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice Nature 376 1995 352 355
70. E. Saito CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse J. Clin. Invest. 109 2002 1453 1462
71. S. Saito Induction of skin fibrosis in mice expressing a mutated fibrillin-1 gene Mol. Med. 6 2000 825 836
72. S. Sato Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells Arthritis Rheum. 50 2004 1918 1927
73. S. Sato Quantitative genetic variation in CD19 expression correlates with autoimmunity J. Immunol. 165 2000 6635 6643
74. S. Sato Clinical significance of anti-topoisomerase I antibody levels by ELISA in systemic sclerosis Rheumatology 40 2001 1135 1140
75. S. Sato Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis J. Dermatol. Sci. 27 2001 140 146
76. S. Sato Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis J. Invest. Dermatol. 120 2003 542 547
77. S. Sato CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice Immunity 5 1996 551 562
78. S. Sato CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity J. Immunol. 157 1996 4371 4378
79. S. Sato CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signalling Proc. Natl. Acad. Sci. U.S.A. 94 1997 13158 13162
80. S. Sato CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19 J. Immunol. 158 1997 4662 4669
81. S. Sato The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation Proc. Natl. Acad. Sci. U.S.A. 92 1995 11558 11562
82. S. Sato CD22 negatively and positively regulates signal transduction through the B lymphocyte receptor Semin. Immunol. 10 1998 287 298
83. M. Schaller Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease Nat. Immunol. 2 2001 746 753
84. M.J. Shlomchik From T to B and back again: positive feedback in systemic autoimmune disease Nat. Rev. Immunol. 1 2001 147 153
85. G.J. Silverman, and S. Weisman Rituximab therapy and autoimmune disorders: prospects for anti-B cell therapy Arthritis Rheum. 48 2003 1484 1492
86. L.D. Siracusa A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation Genome Res. 6 1996 300 313
87. F.K. Tan Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin-1, in patients with scleroderma and other connective tissue diseases J. Immunol. 163 1999 1066 1072
88. T.F. Tedder Introduction: response-regulators of B lymphocyte signaling thresholds provide a context for antigen receptor signal transduction Semin. Immunol. 10 1998 259 265
89. T.F. Tedder The CD19/21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity Immunity 6 1997 107 118
90. T.F. Tedder The CD19/CD21 signal transduction complex of B lymphocytes Immunol. Today 15 1994 437 442
91. D.A. Tuveson CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase Science 260 1993 986 989
92. A. Tyndall, and M. Matucci-Cerinic Haematopoietic stem cell transplantation for the treatment of systemic sclerosis and other autoimmune disorders Expert Opin. Biol. Ther. 3 2003 1041 1049
93. V.A. Wallace A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice Eur. J. Immunol. 24 1994 1463 1466
94. J. Wang, and T. Watanabe Expression and function of Fas during differentiation and activation of B cells Int. Rev. Immunol. 18 1999 367 379
95. W.K. Weng Signaling through CD19 activates vav/mitogen-activated protein kinase pathway and induces formation of a CD19/vav/phosphotidylinositol 3-kinase complex in human B cell precursors J. Biol. Chem. 269 1994 32514 32521
96. M.L. Whitfield Systemic and cell type-specific gene expression patterns in scleroderma skin Proc. Natl. Acad. Sci. U.S.A. 100 2003 12319 12324
97. J.G. Wilson Decreased expression of the C3b/C4b receptor (CR1) and the C3d receptor (CR2) on B lymphocytes and of CR1 on neutrophils of patients with systemic lupus erythematosus Arthritis Rheum. 29 1986 739 747
98. N. Yazawa CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes Blood 102 2003 1374 1380
99. L.-J. Zhou Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B lymphocyte development Mol. Cell. Biol. 14 1994 3884 3894