CD19 Expression Levels Regulate B Lymphocyte Development: Human CD19 Restores Normal Function in Mice Lacking Endogenous CD19

Journal of Immunology

Volumn 158, Issue 10, 1997, Pages 4662-4669

  Sato, Shinichi ^a   Steeber, Douglas A ^a   Jansen, Paul J ^a   Tedder, Thomas F ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CD19 ANTIGEN; IMMUNOGLOBULIN M;

ANIMAL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CYTOLOGY; GENETIC COMPLEMENTATION; GERMINAL CENTER; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, CD19; B-LYMPHOCYTES; CALCIUM; GENETIC COMPLEMENTATION TEST; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN M; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION;

EID: 0031570122     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Goodnow, C. C. 1996. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc. Natl. Acad. Sci. USA 93:2264.
2. Tedder, T. F., M. Inaoki, and S. Sato. 1997. The CD19/21 complex of B lymphocytes: a response-regulator of signal transduction thresholds governing innate immunity, humoral immunity and autoimmunity. Immunity. 6:107.
3. Tedder, T. F., and C. M. Isaacs. 1989. Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes: a new member of the immunoglobulin superfamily. J. Immunol. 143:712.
4. Nadler, L. M., K. C. Anderson, G. Marti, M. Bates, E. Park, J. F. Daley, and S. F. Schlossman. 1983. B4, a human B lymphocyte-associated antigen expressed on normal, mitogen activated, and malignant B lymphocytes. J. Immunol. 131:244.
5. Sato, S., N. Ono, D. A. Steeber, D. S. Pisetsky, and T. F. Tedder. 1996. CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. J. Immunol. 156:4371.
6. Tedder, T. F., L.-J. Zhou, and P. Engel. 1994. The CD19/CD21 signal transduction complex of B lymphocytes. Immunol. Today 15:437.
7. Fearon, D. T., and R. H. Carter. 1995. The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. Annu. Rev. Immunol. 13:127.
8. Engel, P., L.-J. Zhou, DC. Ord, S. Sato, B. Koller, and T. F. Tedder. 1995. Abnormal B lymphocyte development, activation and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3:39.
9. Rickert, R. C., K. Rajewsky, and J. Roes. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376:352.
10. Sato, S., D. A. Steeber, and T. F. Tedder. 1995. The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc. Natl. Acad. Sci. USA 92:11558.
11. Zhou, L.-J., H. M. Smith, T. J. Waldschmidt, R. Schwarting, J. Daley, and T. F. Tedder. 1994. Tissue-specific expression of the human CD19 gene in transgenic mice inhibits Ag-independent B lymphocyte development. Mol. Cell. Biol. 14:3884.
12. Kansas, G. S., and T. F. Tedder. 1991. Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway. J. Immunol. 147:4094.
13. Coffman, R. L., and I. L. Weissman. 1981. B220: a B cell specific member of the T200 glycoprotein family. Nature 289:681.
14. Krop, I., A. R. de Fougerolles, R. A. Hardy, M. Allison, M. S. Schlissel, and D. T. Fearon. 1996. Self-renewal of B-1 lymphocytes is dependent on CD19. Eur. J. Immunol. 26:238.
15. Zhou, L.-J., DC. Ord, A. L. Hughes, and T. F. Tedder. 1991. Structure and domain organization of the CD19 antigen of human, mouse and guinea pig B lymphocytes: conservation of the extensive cytoplasmic domain. J. Immunol. 147:1424.
16. Zhou, L.-J., DC. Ord, S. A. Omori, and T. F. Tedder. 1992. Structure of the genes encoding the CD19 antigen of human and mouse B cells. Immunogenetics 35:102.
17. Killeen, N., S. Sawada, and D. R. Littman. 1993. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 12:1547.
18. Law, Y. M., R. S. M. Yeung, C. Mamalaki, D. Kioussis, T. W. Mak, and R. A. Flavell. 1994. Human CD4 restores normal T cell development and function in mice deficient in murine CD4. J. Exp. Med. 179:1233.
19. Wolf, M. L., J. A. Buckley, A. Goldfarb, C. L. Law, and T. W. LeBien. 1991. Development of a hone marrow culture for maintenance and growth of normal human B cell precursors. J. Immunol. 147:3324.
20. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, R. J. Trent, and A. Basten. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676.
21. Cooke, M. P., A. W. Heath, K. M. Shokat, Y. Zeng, F. D. Finkelman, P. S. Linsley, M. Howard, and C. C. Goodnow. 1994. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J. Exp. Med. 179:425.
22. Cyster, J. G., and C. C. Goodnow. 1995. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2:13.
23. + B cells in viable motheaten and normal mice. Science 232:1423.
24. v) mutant mice. I. Analysis of the development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells. J. Exp. Med. 164:1129.
25. Pani, G., M. Kozlowski, J. C. Cambier, G. B. Mills, and K. A. Siminovitch. 1995. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J. Exp. Med. 181:2077.
26. Sato, S., A. S. Miller, M. Inaoki, C. B. Bock, P. J. Jansen, M. L. K. Tang, and T. F. Tedder. 1996. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity 5:551.
27. Pepys, M. B. 1972. Role of complement in induction of the allergic response. Nat. New Biol. 237:157.
28. Dukor, P., and K. U. Hartmann. 1973. Hypothesis. Bound C3 as the second signal for B-cell activation. Cell. Immunol. 7:349.
29. Fischer, M. B., M. Ma, S. Goerg, X. Zhou, J. Xia, O. Finco, S. Han, G. Kelsoe, R. G. Howard, T. L. Rothstein, E. Kremmer, F. Rosen, and M. C. Carroll. 1996. Regulation of the B cell response to T-dependent antigens by classical pathway complement. J. Immunol. 157:549.
30. Ahearn, J. M., M. B. Fischer, D. Croix, S. Goerg, M. Ma, J. Xia, X. Zhou, R. G. Howard, T. L. Rothstein, and M. C. Carroll. 1996. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 4:251.
31. Molina, H., V. M. Holers, B. Li, Y.-F. Fang, S. Mariathasan, J. Goellner, J. Strauss-Schoenberger, R. W. Karr, and D. D. Chaplin. 1996. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc. Natl. Acad. Sci. USA 93:3357.