Actions of α2 adrenoceptor ligands at α(2A) and 5-HT(1A) receptors: The antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α(2A) adrenoceptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 358, Issue 2, 1998, Pages 197-206

  Newman Tancredi, Adrian ^a   Nicolas, Jean Paul ^a   Audinot, Valérie ^a   Gavaudan, Samantha ^a   Verrièle, Laurence ^a   Touzard, Manuelle ^a   Chaput, Christine ^a   Richard, Nelly ^a   Millan, Mark J ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

( ) Idazoxan; 1 PP; 5 HT(1A) receptors; G protein activation; RX821,002; Yohimbine; 35S GTP S binding; 2 adrenoceptors

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; ALPHA 2A ADRENERGIC RECEPTOR; ATIPAMEZOLE; DEXMEDETOMIDINE; SEROTONIN 1A RECEPTOR; YOHIMBINE; 2-METHOXYIDAZOXAN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; DRUG DERIVATIVE; GUANFACINE; IDAZOXAN; IMIDAZOLE DERIVATIVE; LIGAND; MEDETOMIDINE; QUINOXALINE DERIVATIVE; RECEPTOR, ADRENERGIC, ALPHA 2A; RECEPTOR, ADRENERGIC, ALPHA-2A; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HUMAN; LIGAND BINDING; RAT; RECEPTOR AFFINITY; ANIMAL; BINDING COMPETITION; CHO CELL; DRUG EFFECT; HAMSTER; METABOLISM; RADIOASSAY;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; GUANFACINE; HUMANS; IDAZOXAN; IMIDAZOLES; LIGANDS; MEDETOMIDINE; QUINOXALINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; YOHIMBINE;

EID: 0031594930     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005243     Document Type: Article

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