BU-224 produces spinal antinociception as an agonist at imidazoline I2 receptors

European Journal of Pharmacology

Volumn 333, Issue 1, 1997, Pages 9-15

  Diaz, Alvaro ^a   Mayet, Soraya ^a   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

BU 224 (2 (4,5 dihydroimidazol 2yl) quinoline hydrochloride); Imidazoline receptor; Nociception; Rat; Spinal cord

Indexed keywords

2 (2 IMIDAZOLIN 2 YL)QUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR; ATIPAMEZOLE; IDAZOXAN; IMIDAZOLE DERIVATIVE; IMIDAZOLINE I2 RECEPTOR; QUINOLINE DERIVATIVE; YOHIMBINE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; TOPICAL DRUG ADMINISTRATION;

ADRENERGIC ALPHA-ANTAGONISTS; ANALGESICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; IDAZOXAN; IMIDAZOLES; MALE; NERVE FIBERS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG; SPINAL CORD; SYNAPTIC TRANSMISSION; TRANSCUTANEOUS ELECTRIC NERVE STIMULATION; YOHIMBINE;

EID: 0030805947     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01118-7     Document Type: Article

References (29)

1. Bradley, K.J., Headley, P.M., 1996. Effects of agmatine on spinal nociceptive responses in anaesthetized rats. J. Physiol., 495P, 46 pp.
2. 2 imidazoline receptors. Br. J. Pharmacol. 116:1995;1737-1744.
3. 2 sites. J. Pharmacol. Exp. Ther. 272:1995;681-688.
4. Diamant S., Eldar-Geva T., Atlas D. Imidazoline binding sites in human placenta: evidence for heterogeneity and a search for physiological function. Br. J. Pharmacol. 106:1992;101-108.
5. Dickenson A.H., Le Bars D. Supraspinal morphine and descending inhibitions acting on the dorsal horn of the rat. J. Physiol. 384:1987;81-107.
6. Dickenson A.H., Sullivan A.F. Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn. Pain. 24:1986;211-222.
7. 2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134:1987;1-13.
8. Haley J.E., Sullivan A.F., Dickenson A.H. Evidence for spinal N-methyl D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res. 518:1990;218-226.
9. 2-adrenoceptors. Ann. N.Y. Acad. Sci. 763:1995;8-21.
10. 2 imidazoline ligand, RS 45041, potentiates hyperalgesia in acute arthritis. Neuroreport. 7:1996;1497-1501.
11. 2-sites). Br. J. Pharmacol., 112, 320 pp.
12. 2-antagonists on food and water intake in the rat. Br. J. Pharmacol. 104:1991;258-262.
13. Kolesnikov Y., Jain S., Pasternak G.W. Modulation of opioid analgesia by agmatine. Eur. J. Pharmacol. 296:1996;17-22.
14. Li G., Regunathan S., Barrow C.J., Eshraghi J., Cooper R., Reis D.J. Agmatine: An endogenous clonidine-displacing substance in the rat brain. Science. 263:1994;966-969.
15. Michel M.C., Ernsberger P. Keeping an eye on the I-site: Imidazoline-preferring receptors. Trends Pharmacol. Sci. 13:1992;369-370.
16. Michel M.C., Insel P.A. How many imidazoline-preferring binding sites are there? Trends Pharmacol. Sci. 10:1989;342-344.
17. 2-adrenergic receptors Mol. Pharmacol. 37:1990;65-68.
18. 3H ]RX821002 (2-methoxy idazoxan) in the human and rat brains J. Pharmacol. Exp. Ther. 264:1993;1187-1197.
19. Monroe P.J., Smith D.L., Kirk H.R., Smith D.J. Spinal nonadrenergic imidazoline receptors do not mediate the antinociceptive action of intrathecal clonidine in the rat. J. Pharmacol. Exp. Ther. 273:1995;1057-1062.
20. Morrisey J., McCracken R., Ishidoya S., Klahr S. Partial cloning and characterization of an arginine decarboxylase in the kidney. Kidney Int. 47:1995;1458-1461.
21. 2-adrenergic receptor. J. Biol. Chem. 264:1989;11874-11878.
22. 2-adrenergic receptors. J. Pharmacol. Exp. Ther. 272:1995;581-587.
23. 2-adrenoceptors. Naunyn-Schmiedebergs Arch. Pharmacol. 35:1995;10-16.
24. Raasch W., Regunathan S., Li G., Reis D.J. Agmatine, the bacterial; amine, is widely distributed in mammalian tissues. Life Sci. 56:1995;2319-2330.
25. Regunathan S., Reis D.J. Imidazoline receptors and their endogenous ligands. Annu. Rev. Pharmacol. Toxicol. 36:1996;511-544.
26. 2-adrenergic controls and spinal morphine potency in inflammation. Neuroreport. 5:1994;469-472.
27. 2-adrenoceptor agonist, detects a novel imidazoline binding site in adult rat spinal cord Eur. J. Pharmacol. 306:1996;315-323.
28. Sorkin L.S. NMDA evokes an L-NAME sensitive spinal release of glutamate and citrulline. Neuroreport. 4:1993;479-482.
29. Sullivan A.F., Kalso E.A., McQuay H.J., Dickenson A.H. The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat. Eur. J. Pharmacol. 215:1992;127-133.