Autoradiographical and behavioural effects of a chronic infusion of antisense to the α(2D)-adrenoceptor in the rat

British Journal of Pharmacology

Volumn 128, Issue 3, 1999, Pages 515-522

  Robinson, E S J ^a   Nutt, D J ^a   Hall, L ^a   Jackson, H C ^b   Hudson, A L ^a  

^a SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

^b ABBOTT LABORATORIES   (United States)

Author keywords

2 adrenoceptors; 3H RX821002; Antisense oligonucleotides; Behavioural profile; Mydriasis; Receptor autoradiography; Temperature; UK 14,304

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALPHA 2D ADRENERGIC RECEPTOR; ANTISENSE OLIGONUCLEOTIDE; BETA ADRENERGIC RECEPTOR; BRIMONIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; AUTORADIOGRAPHY; BEHAVIOR; BODY TEMPERATURE; CONTROLLED STUDY; HYPOTHERMIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SEPTUM PELLUCIDUM;

ANIMALS; AUTORADIOGRAPHY; BASE SEQUENCE; BEHAVIOR, ANIMAL; BODY TEMPERATURE; BRAIN; IDAZOXAN; INJECTIONS, INTRAVENTRICULAR; MALE; PUPIL; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; RNA, ANTISENSE;

EID: 0032744030     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702823     Document Type: Article

References (45)

1. 2-adrenoceptor binding and function after irreversible inactivation by n-ethoxycarbonyl-2-ethoxy-1,2-dihydroxyquinoline (EEDQ). Eur. J. Pharmacol., 116, 175-178.
2. BIEGON, A. & ISRAELI, M. (1986). Localisation of the effects of electroconvulsive shock on beta-adrenoceptors in the rat brain. Eur. J. Pharmacol., 123, 329-334.
3. 2-adrenoceptor mechanism. Br. J. Pharmacol., 96, 133-143.
4. 2-adrenoceptors: pharmacology and molecular biological evidence converge. Trends Pharmacol. Sci., 9, 356-361.
5. BYLUND, D.B. (1995). Pharmacological characteristics of alpha-2 adrenergic receptor subtypes. Ann. N. Y. Acad. Sci., 763, 1-7.
6. 2-agonist, is mediated in the locus coeruleus in rats. Aneasthesiology, 76, 948-952.
7. DENNIS, T., L'HEUREUX, R., CARTER, C. & SCATTON, B. (1987). Presynaptic alpha-2 adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline release. J. Pharmacol. Exp. Ther., 241, 642-646.
8. 2 sites in the mammalian central nervous system. Pharmac. Ther., 68, 175-208.
9. GERLAI, R. (1996). Gene-targeting studies of mammalian behaviour: is it the mutation or the background genotype? Trends Neurosci., 19, 177-181.
10. 2D subtype. Eur. J. Pharmacol., 277, 215-221.
11. 2-adrenoceptors. Eur. J. Pharmacol., 170, 19-28.
12. HEAL, D.J., PROW, M.R., BUTLER, S.A. & BUCKETT, W.R. (1995b). Mediation of mydriasis in consious rats by central postsynaptic sti-adrenoceptors. Pharmacol. Biochem. Behavior., 50, 219-224.
13. 2-adrenoceptors in the rat brain. Mol. Neuropharmacol., 1, 219-229.
14. 2-adrenoceptor subtypes to the antinociceptive action of dexmedetomidine and clonidine in rodent models of acute and chronic pain. Br. J. Pharmacol., 120 (suppl) 229P.
15. 2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br. J. Pharmacol., 122, 1339-1344.
16. 2-adrenoceptor activation. J. Pharmacol. Meth., 15, 1-19.
17. LAI, J., BILSKY, E.J. & PORRECA, F. (1995). Treatment with antisense oligodeoxynucleotide to a conserved sequence of opioid receptors inhibits antinociceptive effects of delta subtype selective ligands. J. Recep. Signal Transduction Res., 15, 643-650.
18. 2D-autoreceptors in mouse brain. Naunyn Schmiedebergs Arch. Pharmacol. U.S.A., 352, 43-48.
19. LIN, M.T., JOU, J.J. & KO, W.C. (1981). Effects of intracerebroventricular injection of clonidine on metabolic respiratory, vasomotor and temperature responses in the rabbit. Naunyn Schmiedebergs Arch. Pharmacol. U.S.A., 87, 195-201.
20. 2C-adrenoceptors in rat striatum following antisense oligodeoxynucleotide infusion. Mol. Brain Res., 47, 267-274.
21. 2-adrenoeeptor-subtype function. Trends Pharmacol. Sci., 18, 211-219.
22. 2-Adrenoceptors: more subtypes but fewer functional differences. Trends Pharmacol. Sci., 15, 119-123.
23. MAZE, M. & TRANQUILLI, W. (1991). Alpha-2 adrenoceptor agonists; defining the role in clinical anaesthesia. Anaesthesiology, 74, 581-605.
24. alpha-2A adrenergic receptors in the control of nociception, motor behaviour and hippocampal synthesis of noradrenaline. J. Pharmacol. Exp. Ther., 270, 958-972.
25. 2A-adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus cocruleus of the rat. J. Clin. Investigation, 98, 1076-1080.
26. 2-adrenoceptors and blood pressure regulation in the rat. Eur. J. Pharmacol., 278, 183-185.
27. 2-Adrenoceptors and depression. J. Psychopharmacol., 10 (suppl 3), 35-42.
28. OGAWA, S., BROWN, H.E., OKANO, H.J. & PFAFF, D.W. (1995). Cellular uptake of intracerebrally administered oligodeoxynucleotides in mouse brain. Regulatory Peptides, 59, 143-149.
29. PAXINOS, G. & WATSON, C. (1986). The rat brain in stereotaxic coordinates. New York: Academic Press.
30. 2 dopamine receptors. Mol. Pharmacol., 48, 730-737.
31. REINSTEIN, D.K. & ISSACSON, R.L. (1977), Clonidine sensetivity in the developing rat. Brain Res., 135, 378-382.
32. alpha-2A adrenergic receptors and other populations of alpha-2 adrenergic subtypes. J. Pharmacol. Exp. Ther., 270, 946-957.
33. ROBINSON, E.S.J., NUTT, D.J., JACKSON, H.C. & HUDSON, A.L. (1997). Antisense oligonucleotides in psychopharmacology and behaviour: promises and pitfalls. J. Psychpharmacol., 11, 259-269.
34. 2-adrenoceptor agonist. Mol. Pharmacol., 51, 36-46.
35. SIMONNEAUX, V., EBADI, M. & BYLUND, D.B. (1991), Identification and characterisation of alpha-2D-adrenergic receptors in bovine pineal gland. Mol. Pharmacol., 40, 235-241.
36. STANDIFER, K.M., CHIEN, C.-C., WAHLESTEDT, C., BROWN, G.P. & PASTERNAK, G.W. (1994), Selective loss of δ opioid analgesia and binding by antisense oligodeoxynucleotides to a δ opioid receptor. Neuron, 12, 805-810.
37. 2-adrenoceptors. J. Psychopharmacol., 10 suppl 3, 6-18.
38. TRENDELENBURG, A.U., LIMBERGER, N. & STARKE, K. (1993). Presynaptic alpha 2-autoreceptors in brain cortex: alpha 2D in the rat and alpha 2A in the rabbit. Naunyn-Schmiedeberg's Arch. Pharmacol., 348, 35-45.
39. WAHLESTEDT, C., GOLANOV, E., YAMAMOTO, S., YEE, F., ERICSON, H., YOO, H., INTURRISI, C.E. & REIS, D.J. (1993a). Antisense oligodeoxynuceotides to NMDA-R1 receptor channel protect cortical neurones from excitotoxicity and reduce focal ischaemic infarctions. Nature, 363, 260-263.
40. WAHLESTEDT, C., MERLO-PICH, E., KOOB, G.F., YEE, F. & HEILIG, M. (1993b). Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science, 259, 528-531.
41. WEISS, B., DAVIDKOVA, G. & ZHANG, S.-P. (1997). Antisense strategics in neurobiology. Neurochem. Int., 31, 321-348.
42. 2 messenger RNA. Neuroscience, 55, 607-612.
43. YAIDA, Y. & NOWAK, T.S. (1995). Distribution of phosphodiester and phosphorothioate oligonucleotides in rat brain after intraventricular and intrahippocampal administration determined by in situ hybridisation, Regul. Peptides, 59, 193-199.
44. 2-adrenergic receptor mRNAs in the rat CNS. Mol. Brain Res., 10, 219-225.
45. 2 dopamine receptors in mouse striatum. J. Pharmacol. Exp. Ther., 268, 1015-1023.