PPAR-α-null mice are protected from high-fat diet-induced insulin resistance

Diabetes

Volumn 50, Issue 12, 2001, Pages 2809-2814

  Guerre Millo, Michèle ^a   Rouault, Christine ^a   Poulain, Philippe ^a   André, Jocelyne ^a   Poitout, Vincent ^b   Peters, Jeffrey M ^c,e   Gonzalez, Frank J ^c   Fruchart, Jean Charles ^a   Reach, Gérard ^a   Staels, Bart ^a,d  

^a INSERM   (France)

^b UNIVERSITY OF WASHINGTON   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d INSTITUT PASTEUR DE LILLE   (France)

^e PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; CELL RECEPTOR; DIAGNOSTIC AGENT; GLUCOSE; INSULIN; ISOBUTYLMETHYLXANTHINE; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; DIET RESTRICTION; DRUG EFFECT; DRUG POTENTIATION; FAT INTAKE; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HYPERINSULINEMIA; HYPOGLYCEMIA; INSULIN RESISTANCE; MALE; METABOLISM; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NUTRITIONAL DEFICIENCY; PANCREAS ISLET; PHYSIOLOGY;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMAL; BLOOD GLUCOSE; CARBACHOL; DIETARY FATS; DRUG SYNERGISM; FASTING; GLUCOSE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HYPERINSULINEMIA; HYPOGLYCEMIA; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PALMITIC ACID; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS;

EID: 0035653490     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.12.2809     Document Type: Article

References (35)

1. Eaton S, Bartlett K, Pourfarzam M: Mammalian mitochondrial beta-oxidation. Biochem J 320:345-357, 1996
2. Kurtz DM, Rinaldo P, Rhead WJ, Tian L, Millington DS, Vockley J, Hamm DA, Brix AE, Lindsey JR, Pinkert CA, O'Brien WE, Wood PA: Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc Natl Acad Sci USA 95:15592-15597, 1998
3. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ: Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15:3012-3022, 1995
4. Aoyama T, Peters JM, Iritani N, Nakajima T, Furihata K, Hashimoto T, Gonzalez FJ: Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARα). J Biol Chem 273:5678-5684, 1998
5. Djouadi F, Weinheimer CJ, Saffitz JE, Pitchford C, Bastin J, Gonzalez FJ, Kelly DP: A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice. J Clin Invest 102:1083-1091, 1998
6. Peters JM, Hennuyer N, Staels B, Fruchart JC, Fievet C, Gonzalez FJ, Auwerx J: Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem 272:27307-27312, 1997
7. Costet P, Legendre C, More J, Edgar A, Galtier P, Pineau T: Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J Biol Chem 273:29577-29585, 1998
8. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W: Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 103:1489-1493, 1999
9. Leone TC, Weinheimer CJ, Kelly DP: A critical role for the peroxisome proliferator-activated receptor alpha (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A 96:7473-7478, 1999
10. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W: Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 137:354-366, 1996
11. Zhou YT, Shimabukuro M, Wang MY, Lee Y, Higa M, Milburn JL, Newgard CB, Unger RH: Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Proc Natl Acad Sci U S A 95:8898-8903, 1998
12. Akiyama TE, Nicol CJ, Fievet C, Staels B, Ward JM, Auwerx J, Lee SST, Gonzalez FJ, Peters JM: Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis but is not associated with obesity: studies with congenic mouse lines. J Biol Chem. In press
13. Surwit RS, Petro AE, Parekh P, Collins S: Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. Diabetes 46:1516-1520, 1997 (published erratum appears in Diabetes 46:1920, 1997)
14. Mukherjee R, Davies PJ, Crombie DL, Bischoif ED, Cesario RM, Jow L, Hamann LG, Boehm MF, Mondon CE, Nadzan AM, Paterniti JR, Heyman RA: Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 386:407-410, 1997
15. Poitout V, Rouault C, Guerre-Millo M, Briaud I, Reach G: Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans. Endocrinology 139:822-826, 1998
16. Randle PJ, Garland PB, Newsholme EA, Hales CN: The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus. Ann N Y Acad Sci 131:324-333, 1965
17. Shulman GI: Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176, 2000
18. Lee Y, Wang MY, Kakuma T, Wang ZW, Babcock E, McCorkle K, Higa M, Zhou YT, Unger RH: Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem 276:5629-5635, 2001
19. Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW: Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46:1768-1774, 1997
20. Tordjman K, Bernal-Mizrachi C, Zemany L, Weng S, Feng C, Zhang F, Leone TC, Coleman T, Kelly DP, Semenkovich CF: PPARα deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. J Clin Invest 107:1025-1034, 2001
21. Roduit R, Morin J, Masse F, Segall L, Roche E, Newgard CB, Assimacopoulos-Jeannet F, Prentki M: Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta-cell. J Biol Chem 275:35799-35806, 2000
22. Shimabukuro M, Zhou YT, Lee Y, Unger RH: Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem 273:3547-3550, 1998
23. Patel DD, Knight BL, Wiggins D, Humphreys SM, Gibbons GF: Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice. J Lipid Res 42:328-337, 2001
24. Frederich RC, Lollmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS: Expression of ob mRNA and its encoded protein in rodents: impact of nutrition and obesity. J Clin Invest 90:1658-1663, 1995
25. Ahren B, Scheurink AJ: Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice. Eur J Endocrinol 139:461-467, 1998
26. De Vos P, Lefebvre AM, Miller SG, Guerre-Millo M, Wong K, Saladin R, Hamann LG, Staels B, Briggs MR, Auwerx J: Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. J Clin Invest 98:1004-1009, 1996
27. Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK, Staels B: Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 275:16638-16642, 2000
28. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA: The hormone resistin links obesity to diabetes. Nature 409:307-312, 2001
29. Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ: 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Scei U S A 94:14924-14929, 1997
30. Shiota M, Postic C, Fujimoto Y, Jetton TL, Dixon K, Pan D, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD: Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Diabetes 50:622-629, 2001
31. Bloks V, Plosch T, van Goor H, Roelofsen H, Baller J, Havinga R, Verkade H, van Tol A, Jansen P, Kuipers F: Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient mice. J Lipid Res 42:41-50, 2001
32. Foretz M, Guichard C, Ferre P, Foufelle F: Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci U S A 96:12737-12742, 1999
33. Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM: Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274:1377-1379, 1996
34. Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS: Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141:3388-3396, 2000
35. Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K, Satoh S, Nakano R, Ishii C, Sugiyama T, Eto K, Tsubamoto Y, Okuno A, Murakami K, Sekihara H, Hasegawa G, Naito M, Toyoshima Y, Tanaka S, Shiota K, Kitamura T, Fujita T, Ezaki O, Aizawa S, Kadowaki T: PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 4:597-609, 1999