Overview of mammalian zinc transporters

Cellular and Molecular Life Sciences

Volumn 61, Issue 1, 2004, Pages 49-68

  Kambe, T ^a   Yamaguchi Iwai, Y ^a   Sasaki, R ^b   Nagao, M ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF SHIGA PREFECTURE   (Japan)

Author keywords

CDF; Efflux; Mammalian zinc transporter; Uptake; Zinc homeostasis; ZIP; Znt

Indexed keywords

ANTIBIOTIC AGENT; CLIOQUINOL; MEMBRANE PROTEIN; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER;

ACRODERMATITIS ENTEROPATHICA; ALZHEIMER DISEASE; BINDING COMPETITION; BRAIN ISCHEMIA; CYTOSOL; FACILITATION; GENE MUTATION; HUMAN; ION CURRENT; ION TRANSPORT; METABOLIC REGULATION; MISSENSE MUTATION; NERVE CELL LESION; NERVE CELL NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FAMILY; REVIEW; SEIZURE; SITE DIRECTED MUTAGENESIS; TRANSLATION REGULATION; ZINC METABOLISM;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL MEMBRANE; CYTOPLASM; HOMEOSTASIS; HUMANS; MAMMALS; MODELS, BIOLOGICAL; ZINC;

MAMMALIA;

EID: 1642580782     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-003-3148-y     Document Type: Review

References (167)

1. Vallee B. L. and Falchuk K. H. (1993) The biochemical basis of zinc physiology. Physiol. Rev. 73: 79-118
2. Berg J. M. and Shi Y. (1996) The galvanization of biology: a growing appreciation for the roles of zinc. Science 271: 1081-1085
3. Vallee B. L. and Auld D. S. (1990) Zinc coordination, function and structure of zinc enzymes and other proteins. Biochemistry 29: 5647-5659
4. Venter J. C., Adams M. D., Myers E. W., Li P. W., Mural R. J., Sutton G. G. et al. (2001) The sequence of the human genome. Science 291: 1304-1351
5. Beyersmann D. and Haase H. (2001) Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals 14: 331-341
6. Hambidge M. (2000) Human zinc deficiency. J. Nutr. 130: 1344S-1349S
7. Koh J. Y., Suh S. W., Gwag B. J., He Y. Y., Hsu C. Y. and Choi D. W. (1996) The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272: 1013-1016
8. Krebs N. F. (2000) Overview of zinc absorption and excretion in the human gastrointestinal tract. J. Nutr. 130: 1374S-1377S
9. Victery W., Smith J. M. and Vander A. J. (1981) Renal tubular handling of zinc in the dog. Am. J. Physiol. 241: F532-539
10. Reyes J. G. (1996) Zinc transport in mammalian cells. Am. J. Physiol. 270: 0401-410
11. Coyle P., Philcox J. C., Carey L. C. and Rofe A. M. (2002) Metallothionein: the multipurpose protein. Cell. Mol. Life Sci. 59: 627-647
12. Perez-Clausell J. and Danscher G. (1985) Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study. Brain Res. 337: 91-98
13. Beaulieu C., Dyck R. and Cynader M. (1992) Enrichment of glutamate in zinc-containing terminals of the cat visual cortex. Neuroreport 3: 861-864
14. Zalewski P. D., Millard S. H., Forbes I. J., Kapaniris O., Slavotinek A., Betts W. H. et al. (1994) Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc. J. Histochem. Cytochem. 42: 877-884
15. Williams R. J. P. (1989) An introduction to the biochemistry of zinc. In: Zinc in Human Biology, pp. 15-31, Mills, C. F. (ed), Springer-Verlag, New York
16. Nagao M., Sugaru E., Kambe T. and Sasaki R. (1999) Unidirectional transport from apical to basolateral compartment of cobalt ion in polarized Madin-Darby canine kidney cells. Biochem. Biophys. Res. Commun. 257: 289-294
17. Gunshin H., Mackenzie B., Berger U. V., Gunshin Y., Romero M. F., Boron W. F. et al. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488
18. Sacher A., Cohen A. and Nelson N. (2001) Properties of the mammalian and yeast metal-ion transporters DCT1 and Smf1p expressed in Xenopus laevis oocytes. J. Exp. Biol. 204: 1053-1061
19. Tandy S., Williams M., Leggett A., Lopez-Jimenez M., Dedes M., Ramesh B. et al. (2000) Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells. J. Biol. Chem. 275: 1023-1029
20. Canonne-Hergaux F., Gruenheid S., Ponka P. and Gros P. (1999) Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93: 4406-4417
21. Eide D. and Guerinot M. L. (1997) Metal ion uptake in eukaryotes. ASM News 63: 199-205
22. Eide D. (1997) Molecular biology of iron and zinc uptake in eukaryotes. Curr. Opin. Cell Biol. 9: 573-577
23. Eng B. H., Guerinot M. L., Eide D. and Saier M. H. Jr. (1998) Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins. J. Membr. Biol. 166: 1-7
24. Paulsen I. T. and Saier M. H. Jr. (1997) A novel family of ubiquitous heavy metal ion transport proteins. J. Membr. Biol. 156: 99-103
25. Guerinot M. L. and Eide D. (1999) Zeroing in on zinc uptake in yeast and plants. Curr. Opin. Plant Biol. 2: 244-249
26. McMahon R. J. and Cousins R. J. (1998) Mammalian zinc transporters. J. Nutr. 128: 667-670
27. Cousins R. J. and McMahon R. J. (2000) Integrative aspects of zinc transporters. J. Nutr. 130: 1384S0-1387S
28. Guerinot M. L. (2000) The ZIP family of metal transporters. Biochim. Biophys. Acta. 1465: 190-198
29. Gaither L. A. and Eide D. J. (2001) Eukaryotic zinc transporters and their regulation. Biometals 14: 251-270
30. Hantke K. (2001) Bacterial zinc transporters and regulators. Biometals 14: 239-249
31. Maser P., Thomine S., Schroeder J. I., Ward J. M., Hirschi K., Sze H. et al. (2001) Phylogenetic relationships within cation transporter families of Arabidopsis. Plant Physiol. 126: 1646-1667
32. Harris E. D. (2002) Cellular transporters for zinc. Nutr. Rev. 60: 121-124
33. Ishii K., Sato M., Akita M. and Tomita H. (1999) Localization of zinc in the rat submandibular gland and the effect of its deficiency on salivary secretion. Ann. Otol. Rhinol. Laryngol. 108: 300-308
34. Andrews J. C., Nolan J. P., Hammerstedt R. H. and Bavister B. D. (1995) Characterization of N-(6-methoxy-8-quinolyl)-p-toluenesulfonamide for the detection of zinc in living sperm cells. Cytometry 21: 153-159
35. Danscher G. and Zimmer J. (1978) An improved Timm sulphide silver method for light and electron microscopic localization of heavy metals in biological tissues. Histochemistry 55: 27-40
36. Akagi T., Kaneda M., Ishii K. and Hashikawa T. (2001) Differential subcellular localization of zinc in the rat retina. J. Histochem. Cytochem. 49: 87-96
37. Thorlacius-Ussing O. (1987) Zinc in the anterior pituitary of rat: a histochemical and analytical work. Neuroendocrinology 45: 233-242
38. Frederickson C. J., Perez-Clausell J. and Danscher G. (1987) Zinc-containing 7S-NGF complex. Evidence from zinc histochemistry for localization in salivary secretory granules. J. Histochem. Cytochem. 35: 579-583
39. Frederickson C. J., Suh S. W., Silva D. and Thompson R. B. (2000) Importance of zinc in the central nervous system: the zinc-containing neuron. J. Nutr. 130: 1471S-1483S
40. Sorensen M. B., Stoltenberg M., Juhl S., Danscher G. and Ernst E. (1997) Ultrastructural localization of zinc ions in the rat prostate: an autometallographic study. Prostate 31: 125-130
41. Cole T. B., Wenzel H. J., Kafer K. E., Schwartzkroin P. A. and Palmiter R. D. (1999) Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc. Natl. Acad. Sci. USA 96: 1716-1721
42. Zhao H. and Eide D. (1996) The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation. Proc. Natl. Acad. Sci. USA 93: 2454-2458
43. Zhao H. and Eide D. (1996) The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae. J. Biol. Chem. 271: 23203-23210
44. Grotz N., Fox T., Connolly E., Park W., Guerinot M. L. and Eide D. (1998) Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. Proc. Natl. Acad. Sci. USA 95: 7220-7224
45. Gaither L. A. and Eide D. J. (2001) The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. J. Biol. Chem. 276: 22258-22264
46. Gaither L. A. and Eide D. J. (2000) Functional expression of the human hZIP2 zinc transporter. J. Biol. Chem. 275: 5560-5564
47. Gitan R. S. and Eide D. J. (2000) Zinc-regulated ubiquitin conjugation signals endocytosis of the yeast ZRT1 zinc transporter. Biochem. J. 346 Pt. 2: 329-336
48. Rogers E. E., Eide D. J. and Guerinot M. L. (2000) Altered selectivity in an Arabidopsis metal transporter. Proc. Natl. Acad. Sci. USA 97: 12356-12360
49. 2+ homeostasis. IUBMB Life 49: 249-253
50. Manning D. L., Robertson J. F., Ellis I. O., Elston C. W., McClelland R. A., Gee J. M. et al. (1994) Oestrogen-regulated genes in breast cancer: association of pLIV1 with lymph node involvement. Eur. J. Cancer 30 A: 675-678
51. Manning D. L., McClelland R. A., Knowlden J. M., Bryant S., Gee J. M., Green C. D. et al. (1995) Differential expression of oestrogen regulated genes in breast cancer. Acta Oncol. 34: 641-646
52. Begum N. A., Kobayashi M., Moriwaki Y., Matsumoto M., Toyoshima K. and Seya T. (2002) Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures. Genomics 80: 630-645
53. Stocker W. and Bode W. (1995) Structural features of a superfamily of zinc-endopeptidases: the metzincins. Curr. Opin. Struct. Biol. 5: 383-390
54. Wang K., Zhou B., Kuo Y. M., Zemansky J. and Gitschier J. (2002) A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am. J. Hum. Genet. 71: 66-73
55. Lasswell J., Rogg L. E., Nelson D. C., Rongey C. and Bartel B. (2000) Cloning and characterization of IAR1, a gene required for auxin conjugate sensitivity in Arabidopsis. Plant Cell 12: 2395-2408
56. Costello L. C., Liu Y, Zou J. and Franklin R. B. (1999) Evidence for a zinc uptake transporter in human prostate cancer cells which is regulated by prolactin and testosterone. J. Biol. Chem. 274: 17499-17504
57. Cao J., Bobo J. A., Liuzzi J. P. and Cousins R. J. (2001) Effects of intracellular zinc depletion on metallothionein and ZIP2 transporter expression and apoptosis. J. Leukoc. Biol. 70: 559-566
58. Lee D. K., Geiser J., Dufner-Beattie J. and Andrews G. K. (2003) Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice. J. Nutr. 133: 45-50
59. Zhao H., Butler E., Rodgers J., Spizzo T., Duesterhoeft S. and Eide D. (1998) Regulation of zinc homeostasis in yeast by binding of the ZAP1 transcriptional activator to zinc-responsive promoter elements. J. Biol. Chem. 273: 28713-28720
60. Gitan R. S., Luo H., Rodgers J., Broderius M. and Eide D. (1998) Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocytosis and vacuolar degradation. J. Biol. Chem. 273: 28617-28624
61. Milon B., Dhermy D., Pountney D., Bourgeois M. and Beaumont C. (2001) Differential subcellular localization of hZip1 in adherent and non-adherent cells. FEBS Lett. 507: 241-246
62. MacDiarmid C. W., Gaither L. A. and Eide D. (2000) Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. Embo J. 19: 2845-2855
63. Lioumi M., Ferguson C. A., Sharpe P. T., Freeman T., Marenholz I., Mischke D. et al. (1999) Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. Genomics 62: 272-280
64. Yamaguchi S. (1995) [Subtraction cloning of growth arrest inducible genes in normal human epithelial cells]. Kokubyo Gakkai Zasshi 62: 78-93
65. Van Wouwe J. P. (1989) Clinical and laboratory diagnosis of acrodermatitis enteropathica. Eur. J. Pediatr. 149: 2-8
66. Lombeck T., Schnippering H. G., Ritzl F., Feinendegen L. E. and Bremer H. J. (1975) Letter: absorption of zinc in acrodermatitis enteropathica. Lancet 1: 855
67. Atherton D. J., Muller D. P., Aggett P. J. and Harries J. T. (1979) A defect in zinc uptake by jejunal biopsies in acrodermatitis enteropathica. Clin. Sci, (Lond) 56: 505-507
68. Moynahan E. J. (1974) Letter: Acrodermatitis enteropathica: a lethal inherited human zinc-deficiency disorder. Lancet 2: 399-400
69. Wang K., Pugh E. W., Griffen S., Doheny K. F., Mostafa W. Z., al-Aboosi M. M. et al. (2001) Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. Am. J. Hum. Genet. 68: 1055-1060
70. Kury S., Dreno B., Bezieau S., Giraudet S., Kharfi M., Kamoun R. et al. (2002) Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat. Genet. 31: 239-240
71. Davis S. R., McMahon R. J. and Cousins R. J. (1998) Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. J. Nutr. 128: 825-831
72. Rink L. and Gabriel P. (2001) Extracellular and immunological actions of zinc. Biometals 14: 367-383
73. Manning D. L., Daly R. J., Lord P. G., Kelly K. F. and Green C. D. (1988) Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line. Mol. Cell. Endocrinol. 59: 205-212
74. El-Tanani M. K. and Green C. D. (1997) Interaction between estradiol and growth factors in the regulation of specific gene expression in MCF-7 human breast cancer cells. J. Steroid Biochem. Mol. Biol. 60: 269-276
75. Suzuki A. and Endo T. (2002) Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes. Gene 284: 31-40
76. Palmiter R. D., Cole T. B., Quaife C. J. and Findley S. D. (1996) ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc. Natl. Acad. Sci. USA 93: 14934-14939
77. Abe K., Wei J. F., Wei F. S., Hsu Y. C., Uehara H., Artzt K. et al. (1988) Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos. Embo J. 7: 3441-3449
78. Ando A., Kikuti Y. Y., Shigenari A., Kawata H., Okamoto N., Shiina T. et al. (1996) cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. Genomics 35: 600-602
79. St-Jacques B., Han T. H., MacMurray A. and Shin H. S. (1990) A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice. Mol. Cell. Biol. 10: 138-145
80. Stathakis D. G., Burton D. Y., McIvor W. E., Krishnakumar S., Wright T. R. and O'Donnell J. M. (1999) The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity. Genetics 153: 361-382
81. Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S. et al. (1994) Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1: 223-229
82. Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N. and Ohara O. (1999) Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 337-345
83. Nies D. H. and Silver S. (1995) Ion efflux systems involved in bacterial metal resistances. J. Ind. Microbiol. 14: 186-199
84. Nies D. H. (1992) CzcR and CzcD, gene products affecting regulation of resistance to cobalt, zinc and cadmium (czc system) in Alcaligenes eutrophus. J. Bacteriol. 174: 8102-8110
85. Kamizono A., Nishizawa M., Teranishi Y., Murata K. and Kimura A. (1989) Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiae. Mol. Gen. Genet. 219: 161-167
86. Conklin D. S., McMaster J. A., Culbertson M. R. and Kung C. (1992) COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 12: 3678-3688
87. Palmiter R. D. and Findley S. D. (1995) Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. Embo J. 14: 639-649
88. Anton A., Grosse C., Reissmann J., Pribyl T. and Nies D. H. (1999) CzcD is a heavy metal ion transporter involved in regulation of heavy metal resistance in Ralstonia sp. strain CH34. J. Bacteriol. 181: 6876-6881
89. Lee S. M., Grass G., Haney C. J., Fan B., Rosen B. P., Anton A. et al. (2002) Functional analysis of the Escherichia coli zinc transporter ZitB. FEMS Microbiol. Lett. 215: 273-278
90. Murgia C., Vespignani I., Cerase J., Nobili F. and Perozzi G. (1999) Cloning, expression and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells. Am. J. Physiol. 277: G1231-1239
91. Bloss T., Clemens S. and Nies D. H. (2002) Characterization of the ZAT1p zinc transporter from Arabidopsis thaliana in microbial model organisms and reconstituted proteoliposomes. Planta 214: 783-791
92. Persans M. W., Nieman K. and Salt D. E. (2001) Functional activity and role of cation-efflux family members in Ni hyperaccumulation in Thlaspi goesingense. Proc. Natl. Acad. Sci. USA 98: 9995-10000
93. +. Mol. Microbiol. 45: 145-153
94. MacDiarmid C. W., Milanick M. A. and Eide D. J. (2002) Biochemical properties of vacuolar zinc transport systems of Saccharomyces cerevisiae. J. Biol. Chem. 277: 39187-39194
95. Huang L. and Gitschier J. (1997) A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat. Genet. 17: 292-297
96. Palmiter R. D., Cole T. B. and Findley S. D. (1996) ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. Embo J. 15: 1784-1791
97. Tsuda M., Imaizumi K., Katayama T., Kitagawa K., Wanaka A., Tohyama M. et al. (1997) Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the gerbil. J. Neurosci. 17: 6678-6684
98. McMahon R. J. and Cousins R. J. (1998) Regulation of the zinc transporter ZnT-1 by dietary zinc. Proc. Natl. Acad. Sci. USA 95: 4841-4846
99. Langmade S. J., Ravindra R., Daniels P. J. and Andrews G. K. (2000) The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. J. Biol. Chem. 275: 34803-34809
100. Liuzzi J. P., Blanchard R. K. and Cousins R. J. (2001) Differential regulation of zinc transporter 1, 2 and 4 mRNA expression by dietary zinc in rats. J. Nutr. 131: 46-52
101. 2+) toxicity and modulation by ZnT-1 in PC12 cells. Brain Res. 886: 99-107
102. Huang L., Kirschke C. P., and Gitschier J. (2002) Functional characterization of a novel mammalian zinc transporter, ZnT6. J. Biol. Chem. 277: 26389-26395
103. Jakubowski J. and Kornfeld K. (1999) A local, high-density, single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1. Genetics 153: 743-752
104. Bruinsma J. J., Jirakulaporn T., MuslinA. J., and Kornfeld K. (2002) Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling. Dev. Cell 2: 567-578
105. 2+) makes the difference. Mol. Cell. 9: 927-928
106. Andrews G. K. (2001) Cellular zinc sensors: MTF-1 regulation of gene expression. Biometals 14: 223-237
107. 2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol. Sci. 21: 395-401
108. Sekler I., Moran A., Hershfinkel M., Dori A., Margulis A., Birenzweig N. et al. (2002) Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain. J. Comp. Neurol. 447: 201-209
109. Kobayashi T., Beuchat M. H., Lindsay M., Frias S., Palmiter R. D., Sakuraba H. et al. (1999) Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat. Cell Biol. 1: 113-118
110. Kelleher S. L. and Lonnerdal B. (2002) Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation. J. Nutr. 132: 3280-3285
111. Liuzzi J. P., Bobo J. A., Cui L., McMahon R. J. and Cousins R. J. (2003) Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats during pregnancy and lactation. J. Nutr. 133: 342-351
112. Iguchi K., Usui S., Inoue T., Sugimura Y., Tatematsu M. and Hirano K. (2002) High-level expression of zinc transporter-2 in the rat lateral and dorsal prostate. J. Androl. 23: 819-824
113. Hurley L. S. and Mutch P. B. (1973) Prenatal and postnatal development after transitory gestational zinc deficiency in rats. J. Nutr. 103: 649-656
114. Ogunlewe J. O. and Osegbe D. N. (1989) Zinc and cadmium concentrations in indigenous blacks with normal, hypertrophic and malignant prostate. Cancer 63: 1388-1392
115. Minami A., Takeda A., Yamaide R. and Oku N. (2002) Relationship between zinc and neurotransmitters released into the amygdalar extracellular space. Brain Res. 936: 91-94
116. Frederickson C. J., Rampy B. A., Reamy-Rampy S. and Howell G. A. (1992) Distribution of histochemically reactive zinc in the forebrain of the rat. J. Chem. Neuroanat. 5: 521-530
117. Wenzel H. J., Cole T. B., Born D. E., Schwartzkroin P. A. and Palmiter R. D. (1997) Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey. Proc. Natl. Acad. Sci. USA 94: 12676-12681
118. Lee J. Y., Cole T. B., Palmiter R. D., Suh S. W. and Koh J. Y. (2002) Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proc. Natl. Acad. Sci. USA 99: 7705-7710
119. Jo S. M., Danscher G., Daa Schroder H., Won M. H. and Cole T. B. (2000) Zinc-enriched (ZEN) terminals in mouse spinal cord: immunohistochemistry and autometallography. Brain Res. 870: 163-169
120. Danscher G., Jo S. M., Varea E., Wang Z., Cole T. B. and Schroder H. D. (2001) Inhibitory zinc-enriched terminals in mouse spinal cord. Neuroscience 105: 941-947
121. Wang Z., Li J. Y., Dahlstrom A. and Danscher G. (2001) Zinc-enriched GABAergic terminals in mouse spinal cord. Brain Res. 921: 165-172
122. Wang Z., Danscher G., Kim Y. K., Dahlstrom A. and Mook Jo S. (2002) Inhibitory zinc-enriched terminals in the mouse cerebellum: double- immunohistochemistry for zinc transporter 3 and glutamate decarboxylase. Neurosci. Lett. 321: 37-40
123. 2+ from brain tissue during activity. Nature 308: 734-736
124. Huang E. P. (1997) Metal ions and synaptic transmission: think zinc. Proc. Natl. Acad. Sci. USA 94: 13386-13387
125. 2-: an endogenous modulator of ligand- and voltage-gated ion channels. Neuropharmacology 33: 935-952
126. Smart T. G., Xie X. and Krishek B. J. (1994) Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc. Prog. Neurobiol. 42: 393-341
127. Cole T. B., Martyanova A. and Palmiter R. D. (2001) Removing zinc from synaptic vesicles does not impair spatial learning, memory or sensorimotor functions in the mouse. Brain Res. 891: 253-265
128. Lopantsev V., Wenzel H. J., Cole T. B., Palmiter R. D. and Schwartzkroin P. A. (2003) Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout mice. Neuroscience 116: 237-248
129. Cole T. B., Robbins C. A., Wenzel H. J., Schwartzkroin P. A. and Palmiter R. D. (2000) Seizures and neuronal damage in mice lacking vesicular zinc. Epilepsy Res. 39: 153-169
130. Lee J. Y., Cole T. B., Palmiter R. D. and Koh J. Y. (2000) Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin. J. Neurosci. 20: RC79
131. Bush A. I., Pettingell W. H., Multhaup G., Paradis M. D., Vonsattel J. P., Gusella J. F. et al. (1994) Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265: 1464-1467
132. Bush A. I. and Tanzi R. E. (2002) The galvanization of beta-amyloid in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 99: 7317-7319
133. Atwood C. S., Moir R. D., Huang X., Scarpa R. C., Bacarra N. M., Romano D. M. et al. (1998) Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J. Biol. Chem. 273: 12817-12826
134. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S. et al. (1996) Correlative memory deficits, Abeta elevation and amyloid plaques in transgenic mice. Science 274: 99-102
135. Katzman R., Aronson M., Fuld P., Kawas C., Brown T., Morgenstern H. et al. (1989) Development of dementing illnesses in an 80-year-old volunteer cohort. Ann. Neurol. 25: 317-324
136. Cherny R. A., Atwood C. S., Xilinas M. E., Gray D. N., Jones W. D., McLean C. A. et al. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30: 665-676
137. Piletz J. E. and Ganschow R. E. (1978) Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation. Science 199: 181-183
138. Casey C. E., Hambidge K. M. and Neville M. C. (1985) Studies in human lactation: zinc, copper, manganese and chromium in human milk in the first month of lactation. Am. J. Clin. Nutr. 41: 1193-1200
139. Michalczyk A. A., Allen J., Blomeley R. C. and Ackland M. L. (2002) Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells. Biochem. J. 364: 105-113
140. Rauch H. (1983) Toxic milk, a new mutation affecting cooper metabolism in the mouse. J. Hered. 74: 141-144
141. Michalczyk A. A., Rieger J., Allen K. J., Mercer J. F. and Ackland M. L. (2000) Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementation. Biochem. J. 352 Pt 2: 565-571
142. Hung I. H., Suzuki M., Yamaguchi Y., Yuan D. S., Klausner R. D. and Gitlin J. D. (1997) Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 272: 21461-21466
143. Barila D., Murgia C., Nobili F., Gaetani S. and Perozzi G. (1994) Subtractive hybridization cloning of novel genes differentially expressed during intestinal development. Eur. J. Biochem. 223: 701-709
144. Ranaldi G., Perozzi G., Truong-Tran A., Zalewski P. and Murgia C. (2002) Intracellular distribution of labile Zn(II) and zinc transporter expression in the kidney and in MDCK cells. Am. J. Physiol. Renal Physiol. 283: F1365-1375
145. Erway L. C. and Grider A. Jr. (1984) Zinc metabolism in lethal-milk mice. Otolith, lactation and aging effects. J. Hered. 75: 480-484
146. Kury S., Devilder M. C., Avet-Loiseau H., Dreno B. and Moisan J. P. (2001) Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica. Hum. Genet. 109: 178-185
147. Bleck O., Ashton G. H., Mallipeddi R., South A. P., Whittock N. V., McLean W. H. et al. (2001) Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica. Arch. Dermatol. Res. 293: 392-396
148. Nakano A., Nakano H., Hanada K., Nomura K. and Uitto J. (2002) ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families. Hum. Genet. 110: 201-202
149. Kido T., Sekitani T., Yamashita H., Endo S., Masumitsu Y. and Shimogori H. (1991) Effects of carbonic anhydrase inhibitor on the otolithic organs of developing chick embryos. Am. J. Otolaryngol. 12: 191-195
150. Kambe T., Narita H., Yamaguchi-Iwai Y., Hirose J., Amano T., Sugiura N. et al. (2002) Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. J. Biol. Chem. 277: 19049-19055
151. Cragg R. A., Christie G. R., Phillips S. R., Russi R. M., Kury S., Mathers J. C. et al. (2002) A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. J. Biol. Chem. 277: 22789-22797
152. Inoue K., Matsuda K., Itoh M., Kawaguchi H., Tomoike H., Aoyagi T. et al. (2002) Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Hum. Mol. Genet. 11: 1775-1784
153. Li L. and Kaplan J. (2001) The yeast gene MSC2, a member of the cation diffusion facilitator family, affects the cellular distribution of zinc. J. Biol. Chem. 276: 5036-5043
154. Dodson G. and Steiner D. (1998) The role of assembly in insulin's biosynthesis. Curr. Opin. Struct. Biol. 8: 189-194
155. Clifford K. S. and MacDonald M. J. (2000) Survey of mRNAs encoding zinc transporters and other metal complexing proteins in pancreatic islets of rats from birth to adulthood: similar patterns in the Sprague-Dawley and Wistar BB strains. Diabetes Res. Clin. Pract. 49: 77-85
156. Chakrabartty A. and Stinson R. A. (1985) Properties of membrane-bound and solubilized forms of alkaline phosphatase from human liver. Biochim. Biophys. Acta 839: 174-180
157. Fedde K. N., Blair L., Silverstein J., Coburn S. P., Ryan L. M., Weinstein R. S. et al. (1999) Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. J. Bone Miner. Res. 14: 2015-2026
158. Whyte M. P. (1994) Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization. Endocr. Rev. 15: 439-461
159. Petris M. J., Mercer J. F., Culvenor J. G., Lockhart P, Gleeson P. A. and Camakaris J. (1996) Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking. Embo J. 15: 6084-6095
160. Kirschke C. P. and Huang L. (2003) ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. J. Biol. Chem. 278: 4096-4102
161. Swank R. T., Novak E. K., McGarry M. P., Rusiniak M. E. and Feng, L. (1998) Mouse models of Hermansky Pudlak syndrome: a review. Pigment Cell Res. 11: 60-80
162. Kantheti P., Qiao X., Diaz M. E., Peden A. A., Meyer G. E., Carskadon S. L. et al. (1998) Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes and synaptic vesicles. Neuron 21: 111-122
163. Rolfsen R. M. and Erway L. C. (1984) Trace metals and otolith defects in mocha mice. J. Hered. 75: 159-162
164. Feng L., Seymour A. B., Jiang S., To A., Peden A. A., Novak E. K. et al. (1999) The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pear1, a model for Hermansky-Pudlak syndrome and night blindness. Hum. Mol. Genet. 8: 323-330
165. Yang W, Li C., Ward D. M., Kaplan J. and Mansour S. L. (2000) Defective organellar membrane protein trafficking in Ap3b1-deficient cells. J. Cell Sci. 113 ( Pt 22): 4077-4086
166. Falcon-Perez J. M., Starcevic M., Gautam R. and Dell'Angelica E. C. (2002) BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules. J. Biol. Chem. 277: 28191-28199
167. Huang L., Kuo Y. M. and Gitschier J. (1999) The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency. Nat. Genet. 23: 329-332