Removing zinc from synaptic vesicles does not impair spatial learning, memory, or sensorimotor functions in the mouse

Brain Research

Volumn 891, Issue 1-2, 2001, Pages 253-265

  Cole, Toby B ^a   Martyanova, Amy ^a   Palmiter, Richard D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Behavior; Memory; Mouse; Sensory processing; Zinc; ZnT3

Indexed keywords

CARRIER PROTEIN; CHELATE; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER 3;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; CONDITIONING; CONTROLLED STUDY; FEMALE; HEARING; HOT PLATE TEST; KNOCKOUT MOUSE; LEARNING; MALE; MAZE TEST; MOTOR COORDINATION; MOUSE; NEUROMODULATION; NOCICEPTION; NONHUMAN; OPEN FIELD TEST; PASSIVE AVOIDANCE; PRIORITY JOURNAL; SENSORIMOTOR FUNCTION; SMELLING; SYNAPSE VESICLE; TAIL FLICK TEST; TEMPERATURE; WORKING MEMORY;

ANIMALS; ANXIETY; CARRIER PROTEINS; CENTRAL NERVOUS SYSTEM; EXPLORATORY BEHAVIOR; FEMALE; HEARING; LEARNING; MALE; MEMORY; MICE; MICE, KNOCKOUT; MOVEMENT; NOCICEPTORS; PSYCHOMOTOR PERFORMANCE; SMELL; SPACE PERCEPTION; SYNAPTIC VESICLES; ZINC;

EID: 0035830711     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03220-0     Document Type: Article

References (49)

1. Selective release of endogenous zinc from the hippocampal mossy fibers in situ
2. 2+ from brain tissue during activity
3. A synaptic model of memory: Long-term potentiation in the hippocampus
4. Imaging free zinc in synaptic terminals in live hippocampal slices
5. Seizures and neuronal damage in mice lacking vesicular zinc
6. Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene
7. Zinc in maturing rat brain: Hippocampal concentration and localization
8. Exogenous selenium in the brain. A histochemical technique for light and electron microscopal localization of catalytic selenium bonds
9. The autometallographic zinc-sulphide method. A new approach involving in vivo creation of nanometer-sized zinc sulphide crystal lattices in zinc-enriched synaptic and secretory granules
10. Neurobiology of zinc and zinc-containing neurons
11. A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain
12. In situ binding of bouton zinc reversibly disrupts performance on a spatial memory task
13. Fiber systems in the olfactory bulb and cortex: A study in adult and developing rats, using the timm method and the light and electron microscope
14. 2+: An endogenous modulator of ligand- and voltage-gated ion channels
15. Stimulation-induced uptake and release of zinc in hippocampal slices
16. Water version of the radial-arm maze: Learning in three inbred strains of mice
17. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome
18. Zinc-enriched (ZEN) terminals in mouse spinal cord: Immunohistochemistry and autometallography
19. Zinc-enriched (ZEN) terminals in mouse olfactory bulb
20. Manipulations of zinc in the spinal cord, by intrathecal injection of zinc chloride, disodium-calcium-EDTA, or picolinic acid, alter nociceptive activity in mice
21. Chelation of zinc in the extracellular area of the spinal cord, using EDTA disodium-calcium salt or dipicolinic acid, inhibits the antinociceptive effect of capsaicin in adult mice
22. Reversible inactivation of the hippocampal mossy fiber synapses in mice impairs spatial learning, but neither consolidation nor memory retrieval, in the Morris navigation task
23. A channels by Zn
24. The use of a plus-maze to measure anxiety in the mouse
25. Involvement of the amygdala in memory storage: Interaction with other brain systems
26. Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception
27. Developments of a water-maze procedure for studying spatial learning in the rat
28. A simple quantitative bradykinesia test in MPTP-treated mice
29. ZnT-3, a putative transporter of zinc into synaptic vesicles
30. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc
31. Intravesicular localization of zinc in rat telencephalic boutons: A histochemical study
32. Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons
33. Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes
34. Chemical anatomy of excitatory endings in the dorsal cochlear nucleus of the rat: Differential synaptic distribution of aspartate aminotransferase, glutamate, and vesicular zinc
35. Zinc modulates antagonist interactions with D2-like dopamine receptors through distinct molecular mechanisms
36. Neurons of origin of zinc-containing pathways and the distribution of zinc-containing boutons in the hippocampal region of the rat
37. Postnatal development of zinc-containing cells and neuropil in the hippocampal region of the mouse
38. A receptors are differentially sensitive to zinc: Dependence on subunit composition
39. Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc
40. Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia
41. Disruption of the dopamine β-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory
42. Synaptic transmission and modulation in the olfactory bulb
43. Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions
44. A heavy metal marker of the developing striatal mosaic
45. Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey
46. 2+ antagonize NMDA and GABA responses of hippocampal neurons
47. Prepulse inhibition of the startle response in mice: Relationship to hearing loss and auditory system plasticity
48. A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission
49. Modulation of long-term potentiation in rat hippocampal pyramidal neurons by zinc