Molecular biology of iron and zinc uptake in eukaryotes

Current Opinion in Cell Biology

Volumn 9, Issue 4, 1997, Pages 573-577

  Eide, David ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; IRON; METAL ION; OXIDOREDUCTASE; ZINC;

EUKARYOTE; ION TRANSPORT; IRON TRANSPORT; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SHORT SURVEY;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0030791257     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(97)80036-1     Document Type: Article

References (28)

1. Lesuisse E, Raguzzi F, Crichton RR: Iron uptake by the yeast Saccharomyces cerevisiae: involvement of a reduction step. J Gen Microbiol 1987, 133:3229-3236.
2. Lesuisse E, Labbe P: Reductive and nonreductive mechanisms of iron assimilation by the yeast Saccharomyces cerevisiae. J Gen Microbiol 1989, 135:257-263.
3. 2+ transporter are regulated independently. J Biol Chem 1992, 267:20774-20781.
4. Dancis A, Klausner RD, Hinnebusch AG, Barriocanal JG: Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae. Mol Cell Biol 1990, 10:2294-2301.
5. Dancis A, Roman DG, Anderson GJ, Hinnebusch AG, Klausner RD: Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron. Proc Natl Acad Sci USA 1992, 89:3869-3873.
6. Georgatsou E, Alexandraki D: Two distinctly regulated genes are required for ferric reduction, the first step of iron uptake in Saccharomyces cerevisiae. Mol Cell Biol 1994, 14:3065-3073.
7. 2+ transport protein of Saccharomyces cerevisiae. J Biol Chem 1994, 269:26092-26099.
8. Dix D, Bridgham J, Broderius M, Eide D: Characterization of the Fet4 protein of yeast: evidence for a direct role in the transport of iron. J Biol Chem 1997, 272:11770-11777.
9. Askwith C, Eide D, Ho AV, Bernard PS, Li L, Davis-Kaplan S, Sipe DM, Kaplan J: The Fet3p gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell 1994, 76:403-410.
10. Stearman R, Yuan DS, Yamaguchi-Iwai Y, Klausner RD, Dancis A: A permease-oxidase complex involved in high-affinity iron uptake in yeast Science 1996, 271:1552-1557. Describes the identification of the FTR1 gene and presents a model for the potential role of Ftr1p as the permease subunit in yeast high-affinity iron uptake.
11. Askwith C, Kaplan J: An oxidase-permease-based iron transport system in Schizosaccharomyces pombe and its expression in Saccharomyces cerevisiae. J Biol Chem 1997, 272:401-405. Shows the existence of oxidase-permease-mediated iron uptake in S. pombe. This is an important result because it establishes the existence of this type of system in two extremely divergent eukaryotic organisms.
12. DeSilva DM, Askwith CC, Eide D, Kaplan J: The Fet3p gene product required for high affinity iron transport in yeast is a cell surface ferroxidase. J Biol Chem 1995, 270:1098-1101.
13. Yuan DS, Stearman R, Dancis A, Dunn T, Beeler T, Klausner RD: The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc Natl Acad Sci USA 1995, 92:2632-2636.
14. Dancis A, Yuan DS, Haile D, Askwith C, Eide D, Moehle C, Kaplan J, Klausner RD: Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport Cell 1994, 76:393-402.
15. Osaki S, Johnson DA, Frieden E: The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem 1966, 241:2746-2751.
16. Lee GR, Nacht S, Lukens JN, Cartwright GE: Iron metabolism in copper-deficient swine. J Clin Invest 1968, 47:2058-2069.
17. Yoshida K, Furihata K, Takeda S, Nakamura A, Yamamoto K, Morita H, Hiyamuta S, Ikeda S, Shimizu N, Yanagisawa N: A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. Nat Genet 1995, 9:267-272.
18. Harris L, Takahashi Y, Miyajima H, Serizawa M, MacGillivray RTA, Gitlin JD: Aceruloplasmin: molecular characterization of this disorder of iron metabolism. Proc Natl Acad Sci USA 1995, 92:2539-2543.
19. Guerinot ML, Yi Y: Iron: nutritious, noxious, and not readily available. Plant Physiol 1994, 104:815-820.
20. Bienfait HF: Regulated redox processes at the plasmalemma of plant root cells and their function in iron uptake. J Bioenerg Biomembr 1985, 17:73-83.
21. Buckhout TJ, Bell PF, Luster DG, Chaney RL: Iron-stress induced redox activity in tomato (Lycopersicum esculentum Mill.) is localized on the plasma membrane. Plant Physiol 1989, 90:151-156.
22. 2+ transport in response to iron availability. The methods used in this paper nicely demonstrate the care required to obtain meaningful results from metal uptake experiments.
23. 2+-transport protein from higher eukaryotes.
24. Zhao H, Eide D: The yeast ZRT1 gene encodes the zinc transporter of a high affinity uptake system induced by zinc limitation. Proc Natl Acad Sci USA 1996, 93:2454-2458. Describes the isolation of the first zinc transporter gene from any organism and further indicates the role of ZIP-type transporters in metal uptake.
25. 2+ into yeast cells. Biochim Biophys Acta 1968, 163:325-330.
26. Mowll JL, Gadd GM: Zinc uptake and toxicity in the yeast Sporobolomyces roseus and Saccharomyces cerevisiae. J Gen Microbiol 1983, 129:3421-3425.
27. White C, Gadd GM: The uptake and cellular distribution of zinc in Saccharomyces cerevisiae. J Gen Microbiol 1987, 133:727-737.
28. ••]) of a ZIP-type transporter that is involved in metal uptake.