Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementation

Biochemical Journal

Volumn 352, Issue 2, 2000, Pages 565-571

  Michalczyk, A A ^a   Rieger, J ^a   Allen, K J ^a   Mercer, J F B ^a   Ackland, M L ^a  

^a DEAKIN UNIVERSITY   (Australia)

Author keywords

Homoeostasis; Lactation; Subcellular distribution

Indexed keywords

ADENOSINE TRIPHOSPHATASE; COPPER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; COPPER DEFICIENCY; DIET SUPPLEMENTATION; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; LACTATION; MAMMARY GLAND; MILK; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WILSON DISEASE;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BLOTTING, WESTERN; BREAST; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; COPPER; DIET; DISEASE MODELS, ANIMAL; HEPATOLENTICULAR DEGENERATION; LIVER; MICE; STOMACH; SUBCELLULAR FRACTIONS;

ANIMALIA;

EID: 0034535614     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3520565     Document Type: Article

References (17)

1. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene
2. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene
3. Copper transport in mammals
4. Toxic milk, a new mutation affecting copper metabolism in the mouse
5. The toxic milk mouse is a murine model of Wilson disease
6. The pathology and trace element status of the toxic milk mutant mouse
7. Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onsel hepatic nodular transformation
8. Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces cerevisiae
9. Hepatocyte-specific localization and copper-dependent trafficking of the Wilson's disease protein in the liver
10. Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation
11. Defective copper-induced trafficking and localization of the Menkes protein in patients with mild and copper-treated classical Menkes disease
12. The murine mutation, lethal milk, results in production of zinc-deficient milk
13. Ceruloplasmin is found in milk and amniotic fluid and may have a nutritional role
14. Copper transport in mammals
15. Expression of Menkes disease gene in mammary carcinoma cells
16. Expression of Menkes copper-tranporting ATPase, MNK, in the lactating human breast: Possible role in copper transport into milk