L-type Ca2+ channel-mediated Zn2+ toxicity and modulation by ZnT-1 in PC12 cells

Brain Research

Volumn 886, Issue 1-2, 2000, Pages 99-107

  Kim, Albert H ^a   Sheline, Christian T ^a   Tian, Min ^a   Higashi, Toshio ^a   McMahon, Robert J ^b   Cousins, Robert J ^b   Choi, Dennis W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Bay K 8644; Cell death; PC12; Zinc; ZnT 1

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CARRIER PROTEIN; CASPASE INHIBITOR; NIMODIPINE; PROTEIN ZNT 1; UNCLASSIFIED DRUG; Z VAD; ZINC 65; ZINC CHLORIDE; ZINC ION;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CLONE; CELL DEATH; CELL MEMBRANE; CELL STRAIN; CONTROLLED STUDY; DEPOLARIZATION; DRUG ANTAGONISM; DRUG POTENTIATION; ELECTRON MICROSCOPY; GENETIC MANIPULATION; IMMUNOFLUORESCENCE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GADOLINIUM; MEMBRANE PROTEINS; NECROSIS; NEURONS; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; PC12 CELLS; PYRUVIC ACID; RATS; ZINC;

EID: 0034672431     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02944-9     Document Type: Article

References (58)

1. Metallothioneins in brain - the role in physiology and pathology
2. 2+ from brain tissue during activity
3. The galvanization of biology: a growing appreciation for the roles of zinc
4. Measurement of intracellular free zinc concentrations accompanying zinc-induced neuronal death
5. 2+ in the hippocampal mossy fiber zone of the rat in situ
6. Zinc and brain injury
7. Zinc neurotoxicity in cortical cell culture
8. The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS. A proton activation (PIXE) analysis of carbon tetrachloride extracts from rat brains and spinal cords intravitally treated with dithizone
9. Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death
10. Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures
11. Binding of A 1,4-dihydropyridine calcium channel activator, (-) S Bay K 8644, to cardiac preparations
12. A reappraisal of the role of zinc in life and death decisions of cells
13. Neurobiology of zinc and zinc-containing neurons
14. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
15. 2+: an endogenous modulator of ligand- and voltage-gated ion channels
16. Responses of pyriform cortex neurons to excitatory amino acids: voltage dependence, conductance changes, and effects of divalent cations
17. Stimulation-induced uptake and release of zinc in hippocampal slices
18. Calcium channels in undifferentiated PC12 rat pheochromocytoma cells
19. 2+ entry produces oxidative neuronal necrosis in cortical cell cultures
20. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals
21. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
22. Zinc toxicity on cultured cortical neurons: involvement of N-methyl-D-aspartate receptors
23. The role of zinc in selective neuronal death after transient global cerebral ischemia
24. Nerve growth factor modulates the drug sensitivity of neurotransmitter release from PC-12 cells
25. The neurotoxicity of zinc in the rat hippocampus
26. Zinc-induced neuronal death in cortical neurons [In Process Citation]
27. Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain
28. Characterization of zinc-induced neuronal death in primary cultures of rat cerebellar granule cells
29. Regulation of the zinc transporter ZnT-1 by dietary zinc
30. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis
31. Transition metals in control of gene expression [see comments]
32. ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration
33. ZnT-3, a putative transporter of zinc into synaptic vesicles
34. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc
35. Distribution of terminal fields stained for zinc in the neocortex of the rat
36. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis
37. Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons
38. Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes
39. Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins
40. Measurement of intracellular free zinc in living cortical neurons: routes of entry
41. Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis
42. A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation
43. Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc
44. Biochemical characteristics of caspases-3, -6, -7, and -8
45. Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury
46. The influence of zinc on apoptosis
47. Calcium antagonists high-affinity binding and inhibition of calcium transport in a clonal cell line
48. Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat
49. Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the gerbil
50. The function of metallothionein
51. The biochemical basis of zinc physiology
52. Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat
53. Evidence for a protective role of metallothionein-1 in focal cerebral ischemia
54. AMPA receptor activation potentiates zinc neurotoxicity
55. 2+ antagonize NMDA and GABA responses of hippocampal neurons
56. Neurotrophin receptor structure and interactions [In Process Citation]
57. 2+ permeable AMPA/kainate channels and triggers selective neural injury
58. Brief exposure to zinc is toxic to cortical neurons