Zeroing in on zinc uptake in yeast and plants

Current Opinion in Plant Biology

Volumn 2, Issue 3, 1999, Pages 244-249

  Guerinot, Mary Lou ^a   Eide, David ^b  

^a Dartmouth College ^*  (United States)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARABIDOPSIS;

EID: 0033151564     PISSN: 13695266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5266(99)80042-9     Document Type: Article

References (49)

1. Clarke ND, Berg JM: Zinc fingers in Caenorhabditis elegans: Finding families and probing pathways. Science 1998, 282:2018-2022.
2. Marschner H: Mineral Nutrition of Higher Plants, Edn 2. Boston: Academic Press; 1995.
3. Berg JM, Shi Y: The galvanization of biology: A growing appreciation for the roles of zinc. Science 1996, 271:1081-1085.
4. Ruel MT, Bouis HE: Plant breeding: A long term strategy for the control of zinc deficiency in vulnerable populations. Amer J Clin Nutr 1998, 68:488S-494S. This article describes ongoing plant breeding strategies that could increase the intake of bioavailable zinc from staple food crops. The three most promising breeding strategies include increasing the concentration of zinc, reducing the amount of phytic acid and raising the concentration of sulfur containing amino acids. Phytic acid decreases zinc absorption in humans, whereas addition of sulfur-containing amino acids to the diet has been shown to increase the bioavailability of zinc.
5. Eide DJ: The molecular biology of metal ion transport in Saccharomyces cerevisiae. Annu Rev Nutr 1998, 18:441-469. This is an overview of the genes involved in transport of the transition metals Cu, Fe, Mn and Zn in S. cerevisiae.
6. Zhao H, Eide D: The yeast ZRT1 gene encodes the zinc transporter of a high affinity uptake system induced by zinc limitation. Proc Natl Acad Sci USA 1996, 93:2454-2458.
7. Zhao H, Eide D: The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae. J Biol Chem 1996, 271:23203-23210.
8. Gitan RS, Luo H, Rodgers J, Broderius M, Eide D: Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocytosis and vacuolar degradation. J Biol Chem 1998, 273:28617-28624. Regulated endocytosis of plasma membrane proteins plays an important role in controlling nutrient uptake and responses to extracellular signals. The authors demonstrate that zinc-induced ZRT1 inactivation is a specific regulatory mechanism to shut off zinc uptake in cells exposed to high zinc levels, thereby preventing overaccumulation of this potentially toxic metal. It is clear that we will need to understand such feed-back mechanisms if we wish to design plants that have altered metal content.
9. Eide D, Broderius M, Fett J, Guerinot ML: A novel iron-regulated metal transporter from plants identified by functional expression in yeast. Proc Natl Acad Sci USA 1996, 93:5624-5628.
10. Korshunova YO, Eide D, Clark WG, Guerinot ML, Pakrasi HB: The IRT1 protein from Arabidopsis thaliana is a metal transporter with broad specificity. Plant Mol Biol 1999, 40:37-44.
11. Eng BH, Guerinot ML, Eide D, Saier MHJ: Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins. J Membr Biol 1998,166:1-7.
12. Grotz N, Fox T, Connolly EL, Park W, Guerinot ML, Eide D: Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. Proc Natl Acad Sci USA 1998, 95:7220-7224. This paper reports the identification of the first zinc transporter genes, ZIP1-4, cloned from plants. The genes belong to a family of transporters called the ZIP gene family. ZIP1 and ZIP3 are expressed in roots in response to zinc deficiency, suggesting that they transport zinc from the soil into the plant. ZIP4 is induced in both roots and shoots of zinc-limited plants.
13. Norvell WA, Welch RM: Growth and nutrient uptake by barley (Hordeum vulgare L. cv. Herta): Studies using an N-(2-hydroxyethyl)ethylenedinitrilotriacetic acid-buffered nutrient solution technique. I. Zinc ion requirements. Plant Physiol 1993, 101:619-625.
14. Rengel Z, Hawkesford MJ: Biosynthesis of a 34-kDa polypeptide in the root-cell plasma membrane of a Zn-efficient wheat genotype increases upon Zn deficiency. Aust J Plant Physiol 1997, 24:307-315.
15. Belouchi A, Cellier M, Kwan T, Saini HS, Leroux G, Gros P: The macrophage specific membrane protein Nramp controlling natural resistance in mice has homologues expressed in the root systems of plants. Plant Mol Biol 1995, 29:1181-1196.
16. Belouchi A, Kwan T, Gros P: Cloning and characterization of the OsNramp family from Oryza sativa, a new family of membrane proteins possibly implicated in the transport of metal ions. Plant Mol Biol 1997, 33:1085-1092.
17. Cellier M, Privé G, Belouchi A, Kwan T, Rodrigues V, Chia W, Gros P: Nramp defines a family of membrane proteins. Proc Natl Acad Sci USA 1995, 92:10089-10093.
18. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollon JL, Hediger MA: Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997, 388:482-488.
19. Fleming MD, Trenor CC, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC: Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nature Genet 1997, 16:383-386.
20. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC: Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 1998, 95:1148-1153.
21. Cakmak I, Gülüt KY, Marschner H, Graham RD: Effect of zinc and iron deficiency on phytosiderophore release in wheat genotypes differing in zinc efficiency. J Plant Nutr 1994, 17:1-17.
22. Walter A, Römheld V, Marschner H, Mori S: Is the release of phytosiderophores in zinc-deficient wheat plants a response to impaired iron utilization? Physiol Plantarum 1994, 92:493-500.
23. Fox TC, Guerinot ML: Molecular biology of cation transport in plants. Annu Rev Plant Physiol Plant Mol Biol 1998, 49:669-696. This review summarizes current knowledge about genes whose products function in the transport of various cationic macronutrients (K, Ca) and micronutrients (Cu, Fe, Mn and Zn) in plants.
24. Rengel Z, Römheld V, Marschner H: Uptake of zinc and iron by wheat genotypes differing in tolerance to zinc deficiency. J Plant Physiol 1998, 152:433-438.
25. von Wiren N, Marschner H, Römheld V: Roots of iron-efficient maize also absorb phytosiderophore-chelated zinc. Plant Physiol 1996, 111:1119-1125.
26. Baker AJM, Brooks RR: Terrestrial higher plants which hyperaccumulate metallic elements - A review of their distribution, ecology and phytochemistry. Biorecovery 1989, 1:81-126.
27. Brooks RR, Chambers MF, Nicks LJ, Robinson BH: Phytomining. Trends Plant Sci 1998, 3:359-362.
28. Salt DE, Smith RD, Raskin I: Phytoremediation. Annu Rev Plant Physiol Plant Mol Biol 1998, 49:643-668. An excellent overview of the current information on using plants to clean up the environment. Toxic heavy metals and organic pollutants are the major targets for phytoremediation.
29. 2+ absorption and translocation to shoots in Zn hyperaccumulator and nonaccumulator species of Thlaspi. Plant Physiol 1996, 112:1715-1722.
30. Pence N, Larsen P, Ebbs S, Garvin D, Eide D, Kochian L: Cloning and characterization of a heavy metal transporter (ZNT1) from the Zn/Cd hyperaccumulator Thlaspi caerulescens. Plant Physiol 1998, [Abstract 656 http://www.sheridan.com/aspp98/abs/45/ 0650.html]
31. Lasat MM, Baker AJM, Kochian LV: Altered Zn compartmentation in the root symplasm and stimulated Zn absorption into the leaf as mechanisms involved in Zn hyperaccumulation in Thlaspi caerulescens. Plant Physiol 1998, 118:875-883. The hyperaccumulator Thlaspi caerulescens differs in a number of respects from the related non-hyperaccumulating species Thalspi arvense. The authors show the zinc that is taken up by T. caerulescens is more readily available for loading into the xylem.
32. Shen ZG, Zhao FJ, McGrath P: Uptake and transport of zinc in the hyperaccumutator Thlaspi caerulescens and the non-hyperaccumulator Thlaspi ochroleucum. Plant Cell Environ 1997, 20:898-906.
33. Küpper H, Zhao FJ, McGrath SP: Cellular compartmentation of zinc in leaves of the hyperaccumulator Thlaspi caerulescens. Plant Physiol 1999, 119:305-311.
34. Verkleij JAC, Koevoets PLM, Blake-Kalff MMA, Chardonnens AN: Evidence for an important role of the tonoplast in the mechanism of naturally selected zinc tolerance in Silene vulgaris. J Plant Physiol 1998, in press.
35. Zhao H, Eide D: Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol Cell Biol 1997, 17:5044-5052.
36. Zhao H, Butler E, Rodgers J, Spizzo T, Duesterhoeft S, Eide D: Regulation of zinc homeostasis in yeast by binding of the ZAP1 transcriptional activator to zinc-responsive promoter elements. J Biol Chem 1998, 273:28713-28720.
37. Kamizono A, Nishizawa M, Teranishi Y, Murata K, Kimura A: Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiae. Mol Gen Genet 1989, 219:161-167
38. Conklin DS, McMaster JA, Culbertson MR, Kung C: COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Mol Cell Biol 1992, 12:3678-3688.
39. Conklin DS, Culbertson MR, Kung C: Interactions between gene products involved in divalent cation transport in Saccharomyces cerevisiae. Mol Gen Genet 1994, 244:303-311.
40. Li L, Kaplan J: Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity. J Biol Chem 1998, 273:22181-22187.
41. Paulsen LT, Saier MH: A novel family of ubiquitous heavy metal ion transport proteins. J Membr Biol 1997, 156:99-103.
42. Nies DH: CzcR and CzcD, gene products affecting regulation of resistance to cobalt, zinc and cadmium (czc system) in Alcaligenes eutrophus. J Bacteriol 1992, 174:8102-8110.
43. McMahon RJ, Cousins RJ: Mammalian zinc transporters. J Nutr 1998, 128:667-670.
44. Palmiter RD, Findley SD: Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J 1995, 14:639-649.
45. Palmiter RD, Cole TB, Findley SD: ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J 1996, 15:1784-1791.
46. Palmiter RD, Cole TB, Quaife CJ, Findley SD: ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci USA 1996, 93:14934-14939.
47. Huang L, Gitschier J: A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nature Genetics 1997, 17:292-295.
48. van der Zaal Ej, Neuteboom LW, Pinas JE, Schat H, Verkleij J, Hooykaas PJJ: Overexpression of a zinc transporter gene from Arabidopsis can lead to enhanced zinc resistance and zinc accumulation. Plant Physiol 1999, 119:1-9. A homolog of mammalian zinc effluxers has been identified in Arabidopsis. The authors show that overexpression of the homolog leads to a modest increase in zinc resistance and to an increase in the zinc content of roots. They speculate that ZAT1 may be involved in vacuolar sequestration of zinc.
49. Takatsuji H: Zinc finger proteins: The classic zinc finger emerges in contemporary plant science. Plant Mol Biol 1999, 39:1073-1078.