Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression

Journal of Nutrition

Volumn 128, Issue 5, 1998, Pages 825-831

  Davis, Steven R ^a   McMahon, Robert J ^a   Cousins, Robert J ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Metallothionein knockout mice; Metallothionein transgenic mice; Mice; Zinc absorption; Zinc transporter 1

Indexed keywords

CARRIER PROTEIN; METALLOTHIONEIN; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTESTINE ABSORPTION; MALE; MOUSE; NONHUMAN; TRANSGENIC MOUSE; ZINC BLOOD LEVEL; ZINC METABOLISM;

ANIMALIA; MUS MUSCULUS;

EID: 0031968380     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/128.5.825     Document Type: Article

References (42)

1. Blanchard, R. K. & Cousins, R. J. (1996) Differential display of intestinal mRNAs regulated by dietary zinc. Proc. Natl. Acad. Sci. U.S.A. 93: 6863-6868.
2. 65Zn absorption and body loss in young rats. Br. J. Nutr. 57: 35-44.
3. Cousins, R. J. (1989) Theoretical and practical aspects of zinc uptake and absorption. In: Mineral Absorption in the Monogastric GI Tract: Chemical, Nutritional and Physiological Aspects (Laszlo, J. A. & Dintzis, F. R., eds.), pp. 3-12. Plenum Publishing Corporation, New York, NY.
4. Cousins, R. J. (1996) Zinc. In: Present Knowledge in Nutrition (Filer, L. J. & Ziegler, E. E., eds.), 7th ed., pp. 93-306. International Life Science Institute-Nutrition Foundation, Washington, DC.
5. Coyle, P., Philcox, J. C. & Rofe, A. M. (1995) Hepatic zinc in metallothioneinnull mice following zinc challenge: in vivo and in vitro studies. Biochem. J. 309: 25-31.
6. Dalton, T., Fu, K., Palmiter, R. D. & Andrews, G. K. (1996) Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency. J. Nutr. 126: 825-833.
7. De, S. K., McMaster, M. T. & Andrews, G. K. (1990) Endotoxin induction of murine metallothionein gene expression. J. Biol. Chem. 265: 15267-15274.
8. Dunn, M. A., Blalock, T. L. & Cousins, R. J. (1987) Metallothionein. Proc. Soc. Exp. Biol. Med. 185: 107-119.
9. Dunn, M. A. & Cousins, R. J. (1989) Kinetics of zinc metabolism in the rat: effect of dibutyryl CAMP. Am. J. Physiol. 256: E420-E430.
10. Eaton, D. L. & Toal, B. F. (1982) Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66: 134-142.
11. Farr, C. & Hunt, D. M. (1989) Genetic differences in zinc and copper induction of liver metallothionein in inbred strains of the mouse. Biochem. Genet. 27: 199-217.
12. Flanagan, P. R., Haist, J. & Valberg, L. S. (1983) Zinc absorption, intraluminal zinc and intestinal metallothionein levels in zinc-deficient and zinc-replete rodents. J. Nutr. 113: 962-972.
13. Hempe, J. M. & Cousins, R. J. (1989) Effect of EDTA and zinc-methionine complex on zinc absorption by rat intestine. J. Nutr. 119: 1179-1187.
14. Hoadley, J. E., Leinart, A. S. & Cousins, R. J. (1987) Kinetic analysis of zinc uptake and serosal transfer by vascularly perfused rat intestine. Am. J. Physiol. 252: G825-G831.
15. 65Zn absorption kinetics to intestinal metallothionein in rats: effects of zinc depletion and fasting. J. Nutr. 118: 497-502.
16. Huang, L. & Gitschier, J. (1997) A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat. Gen. 17: 292-295.
17. Iszard, M. B., Liu, J., Liu, Y., Dalton, T., Andrews, G. K., Palmiter, R. D. & Klaassen, C. D. (1995) Characterization of metallothionein-1-transgenic mice. Toxicol. Appl. Pharmacol. 133: 305-312.
18. Kelly, E. J., Quaife, C. J., Froelick, G. J. & Palmiter, R. D. (1996) Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J. Nutr. 126: 1782-1790.
19. Kincaid, R. L., Miller, W. J., Gentry, R. P., Neathery, M. W., Hampton, D. L. & Lassiter, J. W. (1976) The effect of endotoxin upon zinc retention and intracellular liver distribution in rats. Nutr. Rept. Int. 13: 65-70.
20. Liu, J. & Klaassen, C. D. (1996) Absorption and distribution of cadmium in metallothionein-I transgenic mice. Fund. Appl. Toxicol. 29: 294-300.
21. Liu, J., Liu, Y., Michalska, A. E., Choo, K. H. & Klaassen, C. D. (1996) Distribution and retention of cadmium in metallothionein I and II null mice. Toxicol. Appl. Pharmacol. 136: 260-268.
22. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
23. Masters, B. A., Kelly, E. J., Quaife, C. J., Brinster, R. L. & Palmiter, R. D. (1994) Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. U.S.A. 91: 584-588.
24. McCormick, C. C., Menard, M. P. & Cousins, R. J. (1981) Induction of hepatic metallothionein by feeding zinc to rats of depleted zinc status. Am. J. Physiol. 240: E414-E421.
25. McMahon, R. J. & Cousins, R. J. (1998) Mammalian zinc transporters. J. Nutri. 128: 667-670.
26. Menard, M. P., McCormick, C. C. & Cousins, R. J. (1981) Regulation of intestinal metallothionein biosynthesis in rats by dietary zinc. J. Nutr. 111: 1353-1361.
27. Michalska, A. E. & Choo, K.H.A. (1993) Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. U.S.A. 90: 8088-8092.
28. Palmiter, R. D., Cole, T. B. & Findley, S. D. (1996a) ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 15: 1784-1791.
29. Palmiter, R. D., Cole, T. B., Quaife, C. J. & Findley, S. D. (1996b) ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc. Natl. Acad. Sci. U.S.A. 93: 14934-14939.
30. Palmiter, R. D. & Findley, S. D. (1995) Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J. 14: 639-649.
31. Palmiter, R. D., Sandgren, E. P., Koeller, D. M. & Brinster, R. L. (1993) Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol. Cell. Biol. 13: 5266-5275.
32. Paulsen, I. T. & Saier, M. H., Jr. (1997) A novel family of ubiquitous heavy metal ion transport proteins. J. Membr. Biol. 156: 99-103.
33. Pekarek, R. S. & Evans, G. W. (1975) Effect of acute infection and endotoxemia on zinc absorption. Proc. Soc. Exp. Biol. Med. 150: 755-758.
34. Pekarek, R. S. & Evans, G. W. (1976) Effect of leukocytic endogenous mediator (LEM) on zinc absorption in the rat. Proc. Soc. Exp. Biol. Med. 152: 573-575.
35. Philcox, J. C., Coyle, P., Michalska, A., Choo, K. H. & Rofe, A.M. (1995) Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression. Biochem. J. 308: 543-546.
36. Reyes, J. G. (1996) Zinc transport in mammalian cells. Am. J. Physiol. 270: C401-C410.
37. Smith, K. T. & Cousins, R. J. (1980) Quantitative aspects of zinc absorption by isolated, vascularly perfused rat intestine. J. Nutr. 110: 316-323.
38. Smith, K. T., Cousins, R. J., Silbon, B. L. & Failla, M. L. (1978) Zinc absorption and metabolism by isolated, vascularly perfused rat intestine. J. Nutr. 108: 1849-1857.
39. Starcher, B. C., Glauber, J. C. & Madaras, J. G. (1980) Zinc absorption and its relationship to intestinal metallothionein. J. Nutr. 110: 1391-1397.
40. Sullivan, V. K. & Cousins, R. J. (1997) Competitive reverse transcriptase-polymerase chain reaction shows that dietary zinc supplementation in humans increases monocyte metallothionein mRNA levels. J. Nutr. 127: 694-698.
41. Sullivan, J. F., Jetton, M. M. & Burch, R. E. (1979) A zinc tolerance test. J. Lab. Clin. Med. 93: 485-492.
42. Valberg, L. S., Flanagan, P. R., Brennan, J. & Chamberlain, M. J. (1985) Does the oral zinc tolerance test measure zinc absorption? Am. J. Clin. Nutr. 41: 37-42.