Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of IκBα degradation using a peroxisome proliferator-activated receptor-γ-independent mechanism

Journal of Immunology

Volumn 168, Issue 12, 2002, Pages 6232-6243

  Ward, Carol ^a   Dransfield, Ian ^a   Murray, Joanna ^a   Farrow, Stuart N ^a   Haslett, Christopher ^a   Rossi, Adriano G ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN D2; 15 DEOXY DELTA(12,14) PROSTAGLANDIN J2; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 9-DEOXY-9,10-DIDEHYDRO-12,13-DIDEHYDRO-13,14-DIHYDROPROSTAGLANDIN D2; 9-DEOXY-DELTA-9-PROSTAGLANDIN D2; CELL RECEPTOR; DELTA12 PROSTAGLANDIN J2; DNA BINDING PROTEIN; DRUG DERIVATIVE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN RECEPTOR; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN F2ALPHA RECEPTOR; PROSTAGLANDIN J2; PROSTAGLANDIN RECEPTOR; ROSIGLITAZONE; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; ENZYME DEGRADATION; GENE TARGETING; GRANULOCYTE; HOST RESISTANCE; HUMAN; HUMAN CELL; INFLAMMATORY CELL; MEDIATOR RELEASE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RECEPTOR BINDING; BINDING SITE; CELL CULTURE; CELL DEATH; COMPARATIVE STUDY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYMOLOGY; EOSINOPHIL; HYDROLYSIS; METABOLISM; NEUTROPHIL; PEROXISOME; PHYSIOLOGY; PROTEIN SYNTHESIS;

APOPTOSIS; BINDING SITES; CASPASES; CELL DEATH; CELLS, CULTURED; DINOPROST; DNA-BINDING PROTEINS; ENZYME ACTIVATION; EOSINOPHILS; GRANULOCYTES; HUMANS; HYDROLYSIS; I-KAPPA B PROTEINS; NEUTROPHILS; NF-KAPPA B; PEROXISOMES; PROSTAGLANDIN D2; PROTEIN BIOSYNTHESIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS;

EID: 0037096205     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.12.6232     Document Type: Article

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