The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes

Arthritis Research and Therapy

Volumn 5, Issue 5, 2003, Pages

  Elliott, Sarah ^a   Hays, Ezra ^a   Mayor, Michael ^b   Sporn, Michael ^a   Vincenti, Matthew ^a,c  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b Dartmouth Hitchcock Medicel Center   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bcl 3; CDDO; chondrocytes; interleukin 1; matrix metalloproteinase

Indexed keywords

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; COLLAGENASE; COLLAGENASE 3; DRUG DERIVATIVE; INTERSTITIAL COLLAGENASE; MMP13 PROTEIN, HUMAN; OLEANOLIC ACID; ONCOPROTEIN; PROTO ONCOGENE PROTEIN BCL 3; PROTO-ONCOGENE PROTEIN BCL-3; TRANSCRIPTION FACTOR;

ARTICLE; BIOSYNTHESIS; BONE TUMOR; CARTILAGE CELL; CELL CULTURE; CHONDROSARCOMA; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; HUMAN; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; SYNOVIUM; TIME; TUMOR CELL LINE;

BONE NEOPLASMS; CELL LINE, TUMOR; CELLS, CULTURED; CHONDROCYTES; CHONDROSARCOMA; COLLAGENASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; OLEANOLIC ACID; OSTEOARTHRITIS; PROTO-ONCOGENE PROTEINS; SYNOVIAL MEMBRANE; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 1642554140     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar792     Document Type: Article

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