Caveolin, cholesterol, and lipid bodies

Seminars in Cell and Developmental Biology

Volumn 16, Issue 2, 2005, Pages 163-174

  Martin, Sally ^a   Parton, Robert G ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Caveolin; Cholesterol; Lipid body; Regulation; Targeting

Indexed keywords

CAVEOLIN; CHOLESTEROL; CYCLOSPORIN A; FAT DROPLET; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; MEMBRANE PROTEIN; ROSUVASTATIN;

ATHEROSCLEROSIS; BIOGENESIS; CELL COMPARTMENTALIZATION; CELL ORGANELLE; CELL TYPE; CHANARIN DORFMAN SYNDROME; DEVELOPMENTAL DISORDER; DIABETES MELLITUS; FATTY LIVER; HUMAN; HYDROLYSIS; ICHTHYOSIS; INTRACELLULAR MEMBRANE; LIPID STORAGE; LIPIDOSIS; LIPOLYSIS; MAMMAL CELL; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 15944365201     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcdb.2005.01.007     Document Type: Review

References (126)

1. P. Liu, Y. Ying, Y. Zhao, D.I. Mundy, M. Zhu, and R.G. Anderson Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic J Biol Chem 279 2004 3787 3792
2. S. Roy, R. Luetterforst, A. Harding, A. Apolloni, M. Etheridge, and E. Stang Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains Nat Cell Biol 1 1999 98 105
3. A. Pol, R. Luetterforst, M. Lindsay, S. Heino, E. Ikonen, and R.G. Parton A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance J Cell Biol 152 2001 1057 1070
4. A. Pol, S. Martin, M.A. Fernandez, C. Ferguson, A. Carozzi, and R. Luetterforst Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant Mol Biol Cell 15 2004 99 110
5. D.L. Brasaemle, G. Dolios, L. Shapiro, and R. Wang Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes J Biol Chem 279 2004 46835 46842
6. B.L. Trigatti, R.G. Anderson, and G.E. Gerber Identification of caveolin-1 as a fatty acid binding protein Biochem Biophys Res Commun 255 1999 34 39
7. M. Murata, J. Peranen, R. Schreiner, F. Wieland, T.V. Kurzchalia, and K. Simons VIP21/caveolin is a cholesterol-binding protein Proc Natl Acad Sci USA 92 1995 10339 10343
8. C.J. Fielding, and P.E. Fielding Caveolae and intracellular trafficking of cholesterol Adv Drug Deliv Rev 49 2001 251 264
9. E. Ikonen, and R.G. Parton Caveolins and cellular cholesterol balance Traffic 1 2000 212 217
10. E. Ikonen, S. Heino, and S. Lusa Caveolins and membrane cholesterol Biochem Soc Trans 32 2004 121 123
11. D.J. Murphy The biogenesis and functions of lipid bodies in animals, plants and microorganisms Prog Lipid Res 40 2001 325 438
12. D.J. Murphy, and J. Vance Mechanisms of lipid-body formation Trends Biochem Sci 24 1999 109 115
13. M.M. Hussain A proposed model for the assembly of chylomicrons Atherosclerosis 148 2000 1 15
14. S.O. Olofsson, L. Asp, and J. Boren The assembly and secretion of apolipoprotein B-containing lipoproteins Curr Opin Lipidol 10 1999 341 346
15. T.W. Keenan Assembly and secretion of the lipid globules of milk Adv Exp Med Biol 501 2001 125 136
16. S. Prattes, G. Horl, A. Hammer, A. Blaschitz, W.F. Graier, and W. Sattler Intracellular distribution and mobilization of unesterified cholesterol in adipocytes: triglyceride droplets are surrounded by cholesterol-rich ER-like surface layer structures J Cell Sci 113 Pt 17 2000 2977 2989
17. C. Londos, D.L. Brasaemle, J. Gruia-Gray, D.A. Servetnick, C.J. Schultz, and D.M. Levin Perilipin: unique proteins associated with intracellular neutral lipid droplets in adipocytes and steroidogenic cells Biochem Soc Trans 23 1995 611 615
18. C.J. Schultz, E. Torres, C. Londos, and J.S. Torday Role of adipocyte differentiation-related protein in surfactant phospholipid synthesis by type II cells Am J Physiol Lung Cell Mol Physiol 283 2002 L288 L296
19. V. Azais-Braesco, I. Dodeman, S. Delpal, M.C. Alexandre-Gouabau, A. Partier, and P. Borel Vitamin A contained in the lipid droplets of rat liver stellate cells is substrate for acid retinyl ester hydrolase Biochim Biophys Acta 1259 1995 271 276
20. Y. Imanishi, M.L. Batten, D.W. Piston, W. Baehr, and K. Palczewski Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye J Cell Biol 164 2004 373 383
21. P.F. Weller Eosinophils: structure and functions Curr Opin Immunol 6 1994 85 90
22. D.A. Brown Lipid droplets: proteins floating on a pool of fat Curr Biol 11 2001 R446 R449
23. G. van Meer Caveolin, cholesterol, and lipid droplets? J Cell Biol 152 2001 F29 F34
24. E.J. Blanchette-Mackie, N.K. Dwyer, T. Barber, R.A. Coxey, T. Takeda, and C.M. Rondinone Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes J Lipid Res 36 1995 1211 1226
25. K. Tauchi-Sato, S. Ozeki, T. Houjou, R. Taguchi, and T. Fujimoto The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition J Biol Chem 277 2002 44507 44512
26. E. Umlauf, E. Csaszar, M. Moertelmaier, G.J. Schuetz, R.G. Parton, and R. Prohaska Association of stomatin with lipid bodies J Biol Chem 279 2004 23699 23709
27. L.S. Ramsammy, and H. Brockerhoff Lysophosphatidylcholine-cholesterol complex J Biol Chem 257 1982 3570 3574
28. A.B. Novikoff, P.M. Novikoff, O.M. Rosen, and C.S. Rubin Organelle relationships in cultured 3T3-L1 preadipocytes J Cell Biol 87 1980 180 196
29. T. Yamaguchi, N. Omatsu, S. Matsushita, and T. Osumi CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome J Biol Chem 279 2004 30490 30497
30. C. Lefevre, F. Jobard, F. Caux, B. Bouadjar, A. Karaduman, and R. Heilig Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/ thioesterase subfamily, in Chanarin-Dorfman syndrome Am J Hum Genet 69 2001 1002 1012
31. R.A. Igal, J.M. Rhoads, and R.A. Coleman Neutral lipid storage disease with fatty liver and cholestasis J Pediatr Gastroenterol Nutr 25 1997 541 547
32. A. Srebrnik, S. Brenner, B. Ilie, and G. Messer Dorfman-Chanarin syndrome: morphologic studies and presentation of new cases Am J Dermatopathol 20 1998 79 85
33. O. von Bohlen und Halbach, A. Schober, and K. Krieglstein Genes, proteins, and neurotoxins involved in Parkinson's disease Prog Neurobiol 73 2004 151 177
34. N.B. Cole, D.D. Murphy, T. Grider, S. Rueter, D. Brasaemle, and R.L. Nussbaum Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein J Biol Chem 277 2002 6344 6352
35. A.J. Czaja, H.A. Carpenter, P.J. Santrach, and S.B. Moore Host- and disease-specific factors affecting steatosis in chronic hepatitis C J Hepatol 29 1998 198 206
36. J. McLauchlan, M.K. Lemberg, G. Hope, and B. Martoglio Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets EMBO J 21 2002 3980 3988
37. A. Weihofen, K. Binns, M.K. Lemberg, K. Ashman, and B. Martoglio Identification of signal peptide peptidase, a presenilin-type aspartic protease Science 296 2002 2215 2218
38. R.G. Hope, and J. McLauchlan Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein J Gen Virol 81 2000 1913 1925
39. T. Alonzi, C. Agrati, B. Costabile, C. Cicchini, L. Amicone, and C. Cavallari Steatosis and intrahepatic lymphocyte recruitment in hepatitis C virus transgenic mice J Gen Virol 85 2004 1509 1520
40. C. Londos, D.L. Brasaemle, C.J. Schultz, J.P. Segrest, and A.R. Kimmel Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells Semin Cell Dev Biol 10 1999 51 58
41. S. Gronke, M. Beller, S. Fellert, H. Ramakrishnan, H. Jackle, and R.P. Kuhnlein Control of fat storage by a Drosophila PAT domain protein Curr Biol 13 2003 603 606
42. L. Teixeira, C. Rabouille, P. Rorth, A. Ephrussi, and N.F. Vanzo Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism Mech Dev 120 2003 1071 1081
43. J.T. Tansey, C. Sztalryd, J. Gruia-Gray, D.L. Roush, J.V. Zee, and O. Gavrilova Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity Proc Natl Acad Sci USA 98 2001 6494 6499
44. D.L. Brasaemle, T. Barber, N.E. Wolins, G. Serrero, E.J. Blanchette-Mackie, and C. Londos Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein J Lipid Res 38 1997 2249 2263
45. G. Serrero, A. Frolov, F. Schroeder, K. Tanaka, and L. Gelhaar Adipose differentiation related protein: expression, purification of recombinant protein in Escherichia coli and characterization of its fatty acid binding properties Biochim Biophys Acta 1488 2000 245 254
46. E. Diaz, and S.R. Pfeffer TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking Cell 93 1998 433 443
47. S. Miura, J.W. Gan, J. Brzostowski, M.J. Parisi, C.J. Schultz, and C. Londos Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium J Biol Chem 277 2002 32253 32257
48. Y. Fujimoto, H. Itabe, J. Sakai, M. Makita, J. Noda, and M. Mori Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7 Biochim Biophys Acta 1644 2004 47 59
49. I.G. Ganley, K. Carroll, L. Bittova, and S. Pfeffer Rab9 GTPase regulates late endosome size and requires effector interaction for its stability Mol Biol Cell 2004
50. K. Athenstaedt, D. Zweytick, A. Jandrositz, S.D. Kohlwein, and G. Daum Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae J Bacteriol 181 1999 6441 6448
51. T.V. Kurzchalia, and R.G. Parton Membrane microdomains and caveolae Curr Opin Cell Biol 11 1999 424 431
52. P. Liu, M. Rudick, and R.G. Anderson Multiple functions of caveolin-1 J Biol Chem 277 2002 41295 41298
53. R.G. Parton Caveolae - from ultrastructure to molecular mechanisms Nat Rev Mol Cell Biol 4 2003 162 167
54. H. Kogo, K. Ishiguro, S. Kuwaki, and T. Fujimoto Identification of a splice variant of mouse caveolin-2 mRNA encoding an isoform lacking the C-terminal domain Arch Biochem Biophys 401 2002 108 114
55. H. Kogo, and T. Fujimoto Caveolin-1 isoforms are encoded by distinct mRNAs. Identification of mouse caveolin-1 mRNA variants caused by alternative transcription initiation and splicing FEBS Lett 465 2000 119 123
56. I. Parolini, M. Sargiacomo, F. Galbiati, G. Rizzo, F. Grignani, and J.A. Engelman Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex J Biol Chem 274 1999 25718 25725
57. A.M. Fra, E. Williamson, K. Simons, and R.G. Parton De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin Proc Natl Acad Sci USA 92 1995 8655 8659
58. M. Way, and R.G. Parton M-caveolin, a muscle-specific caveolin-related protein FEBS Lett 376 1995 108 112
59. K.S. Song, P.E. Scherer, Z. Tang, T. Okamoto, S. Li, and M. Chafel Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins J Biol Chem 271 1996 15160 15165
60. B. Razani, J.A. Engelman, X.B. Wang, W. Schubert, X.L. Zhang, and C.B. Marks Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities J Biol Chem 276 2001 38121 38138
61. M. Drab, P. Verkade, M. Elger, M. Kasper, M. Lohn, and B. Lauterbach Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice Science 9 2001 9
62. F. Galbiati, J.A. Engelman, D. Volonte, X.L. Zhang, C. Minetti, and M. Li Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities J Biol Chem 276 2001 21425 21433
63. R.G. Parton Life without caveolae Science 293 2001 2405
64. P.E. Scherer, R.Y. Lewis, D. Volonte, J.A. Engelman, F. Galbiati, and J. Couet Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo J Biol Chem 272 1997 29337 29346
65. P. Scheiffele, P. Verkade, A.M. Fra, H. Virta, K. Simons, and E. Ikonen Caveolin-1 and -2 in the exocytic pathway of MDCK cells J Cell Biol 140 1998 795 806
66. F. Galbiati, D. Volonte, C. Minetti, J.B. Chu, and M.P. Lisanti Phenotypic behavior of caveolin-3 mutations that cause autosomal dominant limb girdle muscular dystrophy (LGMD-1C). Retention of LGMD-1C caveolin-3 mutants within the golgi complex J Biol Chem 274 1999 25632 25641
67. D.J. Dietzen, W.R. Hastings, and D.M. Lublin Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae J Biol Chem 270 1995 6838 6842
68. P. Dupree, R.G. Parton, G. Raposo, T.V. Kurzchalia, and K. Simons Caveolae and sorting in the trans-Golgi network of epithelial cells EMBO J 12 1993 1597 1605
69. S. Monier, R.G. Parton, F. Vogel, J. Behlke, A. Henske, and T.V. Kurzchalia VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro Mol Biol Cell 6 1995 911 927
70. R. Montesano, P. Vassalli, A. Perrelet, and L. Orci Distribution of filipin-cholesterol complexes at sites of exocytosis - a freeze-fracture study of degranulating mast cells Cell Biol Int Rep 4 1980 975 984
71. N. Simionescu, F. Lupu, and M. Simionescu Rings of membrane sterols surround the openings of vesicles and fenestrae, in capillary endothelium J Cell Biol 97 1983 1592 1600
72. N.J. Severs, and H.L. Simons Failure of filipin to detect cholesterol-rich domains in smooth muscle plasma membrane Nature 303 1983 637 638
73. N.J. Severs Caveolae: static inpocketings of the plasma membrane, dynamic vesicles or plain artifact? J Cell Sci 90 Pt 3 1988 341 348
74. K.G. Rothberg, J.E. Heuser, W.C. Donzell, Y.S. Ying, J.R. Glenney, and R.G. Anderson A protein component of caveolae membrane coats Cell 68 1992 673 682
75. C. Thiele, M.J. Hannah, F. Fahrenholz, and W.B. Huttner Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles Nat Cell Biol 2 2000 42 49
76. S. Monier, D.J. Dietzen, W.R. Hastings, D.M. Lublin, and T.V. Kurzchalia Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol FEBS Lett 388 1996 143 149
77. A. Uittenbogaard, and E.J. Smart Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae J Biol Chem 275 2000 25595 25599
78. P.E. Fielding, and C.J. Fielding Plasma membrane caveolae mediate the efflux of cellular free cholesterol Biochemistry 34 1995 14288 14292
79. E.J. Smart, Y.S. Ying, P.A. Conrad, and R.G. Anderson Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation J Cell Biol 127 1994 1185 1197
80. E.J. Smart, Y. Ying, W.C. Donzell, and R.G. Anderson A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane J Biol Chem 271 1996 29427 29435
81. L.J. Foster, C.L. De Hoog, and M. Mann Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors Proc Natl Acad Sci USA 100 2003 5813 5818
82. Y. Fu, A. Hoang, G. Escher, R.G. Parton, Z. Krozowski, and D. Sviridov Expression of caveolin-1 enhances cholesterol efflux in hepatic cells J Biol Chem 279 2004 14140 14146
83. L.J. Pike, and L. Casey Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking Biochemistry 41 2002 10315 10322
84. A. Bist, P.E. Fielding, and C.J. Fielding Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol Proc Natl Acad Sci USA 94 1997 10693 10698
85. D. Hailstones, L.S. Sleer, R.G. Parton, and K.K. Stanley Regulation of caveolin and caveolae by cholesterol in MDCK cells J Lipid Res 39 1998 369 379
86. A.M. Fra, E. Pasqualetto, M. Mancini, and R. Sitia Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2 Gene 243 2000 75 83
87. C.J. Fielding, A. Bist, and P.E. Fielding Intracellular cholesterol transport in synchronized human skin fibroblasts Biochemistry 38 1999 2506 2513
88. P. Lau, S.J. Nixon, R.G. Parton, and G.E. Muscat RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR J Biol Chem 279 2004 36828 36840
89. A.J. Carozzi, S. Roy, I.C. Morrow, A. Pol, B. Wyse, and J. Clyde-Smith Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3 J Biol Chem 277 2002 17944 17949
90. C.J. Fielding, and P.E. Fielding Relationship between cholesterol trafficking and signaling in rafts and caveolae Biochim Biophys Acta 1610 2003 219 228
91. P.E. Fielding, P. Chau, D. Liu, T.A. Spencer, and C.J. Fielding Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80 Biochemistry 43 2004 2578 2586
92. S. Shigematsu, R.T. Watson, A.H. Khan, and J.E. Pessin The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4 J Biol Chem 278 2003 10683 10690
93. A. Schlegel, P. Arvan, and M.P. Lisanti Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum J Biol Chem 276 2001 4398 4408
94. B. Razani, T.P. Combs, X.B. Wang, P.G. Frank, D.S. Park, and R.G. Russell Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities J Biol Chem 277 2002 8635 8647
95. P. Thomsen, K. Roepstorff, M. Stahlhut, and B. van Deurs Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking Mol Biol Cell 13 2002 238 250
96. L. Pelkmans, T. Burli, M. Zerial, and A. Helenius Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic Cell 118 2004 767 780
97. M. Kirkham, A. Fujita, R. Chadda, S.J. Nixon, T. Kurzchalia, and D.K. Sharma Ultrastructural identification of uncoated caveolin-independent early endcytic vesicles J Cell Biol 168 2005 465 476
98. S. Heino, S. Lusa, P. Somerharju, C. Ehnholm, V.M. Olkkonen, and E. Ikonen Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface Proc Natl Acad Sci USA 97 2000 8375 8380
99. M. Hao, S.X. Lin, O.J. Karylowski, D. Wustner, T.E. McGraw, and F.R. Maxfield Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle J Biol Chem 277 2002 609 617
100. M.O. Parat, and P.L. Fox Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible J Biol Chem 276 2001 15776 15782
101. A. Uittenbogaard, Y. Ying, and E.J. Smart Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking J Biol Chem 273 1998 6525 6532
102. S. Mukherjee, X. Zha, I. Tabas, and F.R. Maxfield Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog Biophys J 75 1998 1915 1925
103. T. Fujimoto, H. Kogo, K. Ishiguro, K. Tauchi, and R. Nomura Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell J Cell Biol 152 2001 1079 1085
104. A.G. Ostermeyer, J.M. Paci, Y. Zeng, D.M. Lublin, S. Munro, and D.A. Brown Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets J Cell Biol 152 2001 1071 1078
105. D. Marchesan, M. Rutberg, L. Andersson, L. Asp, T. Larsson, and J. Boren A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system J Biol Chem 278 2003 27293 27300
106. AH.C. Huang Oleosins and oil bodies in seeds and other organs Plant Physiol 110 1996 1055 1061
107. P. Targett-Adams, D. Chambers, S. Gledhill, R.G. Hope, J.F. Coy, and A. Girod Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein J Biol Chem 278 2003 15998 16007
108. R.G. Hope, D.J. Murphy, and J. McLauchlan The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins J Biol Chem 277 2002 4261 4270
109. A.G. Ostermeyer, L.T. Ramcharan, Y. Zeng, D.M. Lublin, and D.A. Brown Role of the hydrophobic domain in targeting caveolin-1 to lipid droplets J Cell Biol 164 2004 69 78
110. N. Nakamura, and T. Fujimoto Adipose differentiation-related protein has two independent domains for targeting to lipid droplets Biochem Biophys Res Commun 306 2003 333 338
111. A. Garcia, A. Sekowski, V. Subramanian, and D.L. Brasaemle The central domain is required to target and anchor perilipin A to lipid droplets J Biol Chem 278 2003 625 635
112. M.A. Welte, S.P. Gross, M. Postner, S.M. Block, and E.F. Wieschaus Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics Cell 92 1998 547 557
113. H. Jackle, and R. Jahn Vesicle transport: klarsicht clears up the matter Curr Biol 8 1998 R542 R544
114. C. Valetti, D.M. Wetzel, M. Schrader, M.J. Hasbani, S.R. Gill, and T.E. Kreis Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170 Mol Biol Cell 10 1999 4107 4120
115. P.E. Scherer, M.P. Lisanti, G. Baldini, M. Sargiacomo, C.C. Mastick, and H.F. Lodish Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles J Cell Biol 127 1994 1233 1243
116. A.W. Cohen, B. Razani, W. Schubert, T.M. Williams, X.B. Wang, and P. Iyengar Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation Diabetes 53 2004 1261 1270
117. D.L. Brasaemle, D.M. Levin, D.C. Adler-Wailes, and C. Londos The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets Biochim Biophys Acta 1483 2000 251 262
118. G.M. Clifford, C. Londos, F.B. Kraemer, R.G. Vernon, and S.J. Yeaman Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes J Biol Chem 275 2000 5011 5015
119. C. Sztalryd, G. Xu, H. Dorward, J.T. Tansey, J.A. Contreras, and A.R. Kimmel Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation J Cell Biol 161 2003 1093 1103
120. B. Razani, C.S. Rubin, and M.P. Lisanti Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A J Biol Chem 274 1999 26353 26360
121. I. Tabas Consequences of cellular cholesterol accumulation: basic concepts and physiological implications J Clin Invest 110 2002 905 911
122. P. Gargalovic, and L. Dory Cellular apoptosis is associated with increased caveolin-1 expression in macrophages J Lipid Res 44 2003 1622 1632
123. B. Feng, P.M. Yao, Y. Li, C.M. Devlin, D. Zhang, and H.P. Harding The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages Nat Cell Biol 5 2003 781 792
124. M. Pelat, C. Dessy, P. Massion, J.P. Desager, O. Feron, and J.L. Balligand Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo Circulation 107 2003 2480 2486
125. P. Gargalovic, and L. Dory Caveolins and macrophage lipid metabolism J Lipid Res 44 2003 11 21
126. P.G. Frank, H. Lee, D.S. Park, N.N. Tandon, P.E. Scherer, and M.P. Lisanti Genetic ablation of caveolin-1 confers protection against atherosclerosis Arterioscler Thromb Vasc Biol 24 2004 98 105