Caveolae and intracellular trafficking of cholesterol

Advanced Drug Delivery Reviews

Volumn 49, Issue 3, 2001, Pages 251-264

  Fielding, Christopher J ^a   Fielding, Phoebe E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Caveolae; Caveolin; Free cholesterol; Signaling; Trafficking

Indexed keywords

BIOLOGICAL MEMBRANES; BIOSENSORS; BIOSYNTHESIS; CELL CULTURE; CELLS; CHOLESTEROL;

TRAFFICKING;

PHARMACODYNAMICS;

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; APOLIPOPROTEIN A1; CAVEOLIN 1; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CYCLIN D1; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; SCAVENGER RECEPTOR;

CAVEOLA; CELL ADHESION; CELL CYCLE; CELL FUNCTION; CELL GROWTH; CHOLESTEROL TRANSPORT; COMPLEX FORMATION; ENDOCYTOSIS; HOMEOSTASIS; HUMAN; INTRACELLULAR TRANSPORT; MEMBRANE STRUCTURE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SENSOR;

ANIMALS; CAVEOLAE; CHOLESTEROL; HUMANS; INTRACELLULAR FLUID; LIPOPROTEINS;

EID: 0035963902     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(01)00140-5     Document Type: Review

References (119)

1. The caveolae membrane system
2. Caveolins, liquid-ordered domains, and signal transduction
3. Detergent-insoluble glycolipid/cholesterol-rich membrane domains, lipid rafts and caveolae
4. Membrane microdomains and caveolae
5. Cholesterol and caveolae - Structural and functional relationships
6. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
7. Localization and turnover of phosphatidylinositol 4,5-biphosphate in caveolin-enriched membrane domains
8. Compartmentalized production of ceramide at the cell surface
9. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed in muscle
10. Caveolae require intact VAMP for targeted transport in vascular endothelium
11. Localization of the insulin receptor in caveolae of adipocytes
12. Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae
13. NEM inhibits transcytosis, endocytosis and capillary permeability: Implication of caveolae fusion in endothelium
14. Identification of peptide and protein ligands for the caveolin scaffold domain. Implications for the interaction of caveolin with caveolae-associated proteins
15. Evidence for a regulated interaction between heterotrimeric G-proteins and caveolin
16. Caveolin is an activator of insulin receptor signaling
17. Involvement of cellular caveolae in bacterial entry into mast cells
18. Reduction of caveolin and caveolae in oncogenically transformed cells
19. Recombinant expression of caveolin-1 in oncogenically transformed cells abroagates anchorage-independent growth
20. Intracellular cholesterol transport in synchronized human skin fibroblasts
21. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling
22. Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3)
23. Caveolin-1 regulates shear stress dependent activation of extracellular signal-regulated kinase
24. Functional rafts in cell membranes
25. Functions of lipid rafts in biological membranes
26. Rings of membrane sterols surrounding the openings of vesicles and fenestrae in capillary endothelium
27. Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation
28. VIP21/caveolin is a cholesterol-binding protein
29. Expression and characterization of recombinant caveolin. Purification of polyhistidine tagging and cholesterol-dependent incorporation into defined lipid membranes
30. Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol
31. Oligomeric strcuture of caveolin: Implications for caveolae membrane organization
32. Caveolin is palmitoylated on multiple cysteine residues: Palmitoylation is not necessary for localization of caveolin to caveolae
33. A role for the caveolin scaffolding domain in mediating the membrane attachment of caveolin-1. The caveolin scaffolding domain is both necessary and sufficient for membrane binding in vitro
34. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T-lymphocytes
35. GPI-anchored proteins are organized in submicron domains at the cell surface
36. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells
37. Separation of caveolae from associated microdomains of GPI-anchored proteins
38. A detergent free method for purifying caveolae membrane from tissue culture cells
39. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolar microdomains. Detergent-free purification of caveolar microdomains
40. Caveolae, caveolin and caveolin-rich microdomains: A signaling hypothesis
41. High density lipoprotein-mediated cholesterol uptake and targeting to lipid droplets in intact L-cell fibroblasts. A single and multiphoton fluorescence approach
42. PC12 cells have caveolae that contain TrkA. Caveola-disrupting drugs inhibit NGF- but not EGF-induced MAPK-induced phosphorylation
43. Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate
44. Cholesterol depletion of caveolae causes hyperactivation of extracellular signal related kinase (ERK)
45. Protein kinase C (alpha) activity downregulates through caveolae-dependent traffic to an endosomal compartment
46. Plasma membrane cholesterol is a key molecule in shear stress dependent activation of extracellular signal-regulated kinase
47. Cell cholesterol efflux: Integration of old and new observations provides new insight
48. Cholesterol transfer from small and large unilamellar vesicles
49. Molecular physiology of reverse cholesterol transport
50. The role of the high density lipoprotein receptor SR-BI in cholesterol metabolism
51. Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells
52. Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile
53. Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic mice
54. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) scavenger receptor class B type I reveals its key role in HDL metabolism
55. Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae
56. Coexpression of scavenger receptor BI and caveolin 1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages
57. Scavenger receptor class B type I as a mediator of cellular cholesterol efflux to lipoproteins and phospholipid acceptors
58. 3H-cholesterol efflux to high and low density lipoprotein is dependent on lipoprotein binding to the receptor
59. Scavenger receptor BI (SR-BI) mediates free cholesterol efflux independently of HDL tethering to the cell surface
60. Plasma membrane caveolae mediate the efflux of cellular free cholesterol
61. Caveolin mRNA levels are upregulated by free cholesterol and downregulated by oxysterols in fibroblast monolayers
62. Caveolin-1 expression and its role in cholesterol efflux in rat hepatoma cells
63. The ABCA subclass of mammalian transporters
64. The high density lipoprotein and apolipoprotein A-1 induced mobilization of cellular cholesterol is impaired in fibroblasts from Tangier Disease subjects
65. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-1 in Tangier Disease
66. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux
67. ABCA1 is the cAMP-inducible receptor that mediates cholesterol secretion from macrophages
68. Tyrosine phosphorylation of caveolin-1 in the endothelium
69. A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A1
70. HDL-mediated efflux of intracellular cholesterol is impaired in fibroblasts from Tangier Disease patients
71. Apolipoprotein-mediated lipid efflux does not derive from membrane caveolae domains
72. Cholesterol efflux to apolipoprotein A-1 involves endocytosis and resecretion in a calcium-dependent pathway
73. The correlation of ATP binding cassette 1 mRNA levels with cholesterol efflux from various cell lines
74. A role for caveolin in the transport of cholesterol from endoplasmic reticulum to plasma membrane
75. Dissecting the roles of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface
76. Characterization of a cytosolic heat shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking
77. Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae
78. Caveolin is palmitoylated at multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae
79. Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps
80. Dynamin-mediated internalization of caveolae
81. Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium
82. Caveolae and sorting in the trans-Golgi network
83. VIP21-caveolin, a 21 kD membrane protein, is an integral component of trans-Golgi derived vesicles
84. Cholesterol and the Golgi apparatus
85. Cholesterol and stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane
86. Enrichment of acyl CoA: Cholesterol acyltransferase near transGolgi network and endocytic recycling compartments
87. A receptor-mediated pathway for cholesterol homeostasis
88. Selective uptake of lipoprotein free cholesterol and its intracellular transport - Role of caveolae
89. Dominant negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
90. Regulation of caveolin and caveolae by cholesterol in MDCK cells
91. Role of a N-ethylmaleimide sensitive factor in the selective cellular uptake of low density lipoprotein free cholesterol
92. Intracellular transport of low density lipoprotein-derived free cholesterol begins at clathrin-coated pits and terminates at cell surface caveolae
93. Oligomerized transferrin receptors are selectively retained by a luminal sorting signal in a long-lived endocytic recycling compartment
94. Cholesterol-dependent retention of GPI-anchored proteins in endosomes
95. The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components
96. Intracellular cholesterol trafficking: Role of the NPC-1 protein
97. Functional architecture of an intracellular t-SNARE
98. Role of Niemann-Pick Type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol
99. Sterol-mediated glycolipid sorting occurs in Niemann-Pick C-1 late endosomes
100. ATP-ase defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking
101. Intracellular trafficking of lysosomal membrane proteins
102. Syntaxin 7 mediates endocytic trafficking to late endosomes
103. Role of caveolae in cholesterol transport in arterial smooth muscle cells exposed to lipoproteins in vivo and in vitro
104. Regulation of caveolin-1 by low density lipoprotein in human endothelial cells
105. Two sterol regulatory element-like sequences mediate upregulation of caveolin gene transcription in response to low density lipoprotein free cholesterol
106. Regulation of the mevalonate pathway
107. Intracellular cholesterol transport
108. Sterol regulatory element binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
109. Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2
110. Upregulation of caveolae and caveolar constituents in multidrug resistant cancer cells
111. Upregulation of caveolin-1 and caveolae organelles in taxol-resistant A549 cells
112. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells
113. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth
114. p53 regulates caveolin gene transcription, cell cholesterol and growth by a novel mechanism
115. Regulation of E2F: A family of transcription factors involved in proliferation control
116. The paradox of E2F1 oncogene and tumor suppressor gene
117. p53, the cellular gatekeeper for growth and division
118. Database of p53 gene somatic mutations in human tumors and cell lines
119. The cyclin D1 gene is transcriptionally repressed by caveolin-1