Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells

Seminars in Cell and Developmental Biology

Volumn 10, Issue 1, 1999, Pages 51-58

  Londos, Constantine ^a   Brasaemle, Dawn L ^c   Schultz, Charles J ^d   Segrest, Jere P ^b   Kimmel, Alan R ^d  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d NONE

Author keywords

Adipocyte; ADRP; Lipid storage droplets; Perilipin

Indexed keywords

ANIMALIA;

ADFP PROTEIN, HUMAN; ADFP PROTEIN, MOUSE; CARRIER PROTEIN; DNA BINDING PROTEIN; M6PRBP1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MESSENGER RNA; PERILIPIN A; PERILIPIN B; PHOSPHOPROTEIN; PLACENTA PROTEIN; SIGNAL PEPTIDE; VIMENTIN;

ANIMAL; CELL STRAIN 3T3; GENE EXPRESSION REGULATION; INTRACELLULAR FLUID; LIPID METABOLISM; LIPOLYSIS; METABOLISM; MOUSE; PHYSIOLOGY; REVIEW;

3T3 CELLS; ANIMALS; CARRIER PROTEINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; INTRACELLULAR FLUID; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPID METABOLISM; LIPOLYSIS; MEMBRANE PROTEINS; MICE; PHOSPHOPROTEINS; PREGNANCY PROTEINS; RNA, MESSENGER; VIMENTIN;

EID: 0033071156     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.1998.0275     Document Type: Article

References (41)

1. Murphy DJ (1993) Structure, function and biogenesis of storage lipid bodies and oleosins in plants. Prog Lipid Res 32:247-280
2. Huang AH (1996) Oleosins and oil bodies in seeds and other organs. Plant Physiol 110:1055-1061
3. Napier JA, Stobart AK, Shewry PR (1996) The structure and biogenesis of plant oil bodies: the role of the ER membrane and the oleosin class of proteins. Plant Mol Biol 31:945-956
4. Murphy DJ, Vance J (1999) Mechanisms of lipid-body formation. TIBS, in press
5. Wang SM, Fong TH (1995) A lipid droplet-specific capsule is present in rat adrenal cells: evidence from a monoclonal antibody. Biochem Biophys Res Commun 217:81-88
6. Fong TH, Wang SM, Lin HS (1996) Immunocytochemical demonstration of a lipid droplet-specific capsule in cultured Leydig cells of the golden hamsters. J Cell Biochem 63: 366-373
7. Fong TH, Wang SM (1997) Dissection of the signalling mechanism for capsule detachment of lipid droplets in rat adrenocortical cells. J Cell Biochem 65:67-74
8. Wang SM, Fong TH, Hsu SY, Chien CL, Wu JC (1997) Reorganization of a novel vimentin-associated protein in 3T3-L1 cells during adipose conversion. J Cell Biochem 67:84-91
9. Franke WW, Hergt M, Grund C (1987) Rearrangement of the vimentin cytoskeleton during adipose conversion: formation of an intermediate filament cage around lipid globules. Cell 49:131-141
10. Lieber JG, Evans RM (1996) Disruption of the vimentin intermediate filament system during adipose conversion of 3T3-L1 cells inhibits lipid droplet accumulation. J Cell Sci 109:3047-3058
11. Weller PF, Dvorak AM (1994) Lipid bodies: intracellular sites for eicosanoid formation. J Allergy Clin Immunol 94: 1151-1156
12. Yu W, Bozza PT, Tzizik DM, Gray JP, Cassara J, Dvorak AM, Weller PF (1998) Co-compartmentalization of MAP kinases and cytosolic phospholipase A2 at cytoplasmic arachidonate-rich lipid bodies. Am J Pathol 152:759-769
13. Bozza PT, Yu W, Penrose JF, Morgan ES, Dvorak AM, Weller PF (1997) Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. J Exp Med 186:909-920
14. Londos C, Brasaemle DL, Gruia-Gray J, Servetnick DA, Schultz CJ, Levin DM, Kimmel AR (1995) Perilipin: Unique proteins associated with intracellular neutral lipid droplets in adipocytes and steroidogienic cells. Biochem Soc Trans 23:611-615
15. Londos C, Gruia-Gray J, Brasaemle DL, Rondinone CM, Takeda T, Dwyer NK, Barber T, Kimmel AR, Blanchette-Mackie EJ (1996) Perilipin: possible roles in structure and metabolism of intracellular neutral lipid in adipocytes and steroidogenic cells. Int J Obesity 20:S97-S101
16. Egan JJ, Greenberg AS, Chang MK, Londos C (1990) Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. J Biol Chem 265:18769-18775
17. Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C (1991) Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem 266: 11341-11346
18. Greenberg AS, Egan JJ, Wek SA, Moos MC, Jr, Londos C, Kimmel AR (1993) Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc Natl Acad Sci USA 90:12035-12039
19. Servetnick DA, Brasaemle DL, Gruia-Gray J, Kimmel AR, Wolff J, Londos C (1995) Perilipins are associated with cholesterol ester droplets in steroidogenic adrenal cortical and Leydig cells. J Biol Chem 270:16970-16973
20. Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Takeda T, Rondinone CM, Theodorakis JL, Greenberg AS, Londos C (1995) Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. J Lipid Res 36: 1211-1226
21. Jiang HP, Serrero G (1992) Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci USA 89:7856-7860
22. Eisinger DP, Serrero G (1993) Structure of the gene encoding mouse adipose differentiation-related protein (ADRP). Genomics 16:638-644
23. Diaz E, Pfeffer SR (1998) TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. Cell 93:433-443
24. Than NG, Sumegi B, Than GN, Kispal G, Bohn H (1998) Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants. Eur J Biochem 258:752-757
25. Scherer PE, Bickel PE, Kotler M, Lodish HF (1998) Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Nat Biotechnol 16:581-586
26. Brasaemle DL, Barber T, Wolins ND, Serrero G, Blanchette-Mackie EJ, Londos C (1997) Adipose differentiation-related protein in an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 38:2249-2263
27. Heid HW, Moll R, Schwetlick I, Rackwitz HR, Keenan TW (1998) Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res 294:309-321
28. Steiner S, Wahl D, Mangold BLK, Robison R, Raymackers J, Meheus L, Anderson NL, Cordier A (1996) Induction of the adipose differentiation-related protein in liver of etoxomirtreated rats. Biochem Biophys Res Commun, 218:777-782
29. Senior JR, Isselbacher KJ (1962) Direct esterification of monoglycerides with palmityl Coenzyme A by intestinal epithelial subcellular fractions. J Biol Chem 237:1454-1459
30. Reinhart MP, Billheimer JT, Faust JR, Gaylor JL (1987) Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver. J Biol Chem 262:9649-9655
31. Brindley DN, Hubscher G (1995) The intracellular distribution of the enzymes catalyzing the biosynthesis of glycerides in the intestinal mucosa. Biochim Biophys Acta 106:495-509
32. Segrest JP, Jones MK, Mishra VK, Anantharamaiah GM, Garber DW (1994) apoB-100 has a pentapartite structure composed of three amphipathic alpha-helical domains alternating with two amphipathic beta-strand domains. Detection by the computer program LOCATE. Arterioscler Thromb 14:1674-1685
33. Brasaemle DL, Barber T, Kimmel AR, Londos C (1997) Posttranslational regulation of perilipin expression: Stabilization by stored intracellular neutral lipids. J Biol Chem 272:9378-9387
34. Anthonsen MW, Ronnstrand L, Wernstedt C, Degerman E, Holm C (1998) Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J Biol Chem 273:215-221
35. Egan JJ, Greenberg AS, Chang MK, Wek SA, Moos MC, Jr, Londos C (1992) Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet. Proc Natl Acad Sci USA 89: 8537-8541
36. Brasaemle DL, Levin DM, Adler-Wailes DA, Londos C (1999) The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of cytosolic hormone-sensitive lipase to the surfaces of lipid storage droplets. Submitted
37. Honnor RC, Dhillon GS, Londos C (1985) cAMP-dependent protein kinase and lipolysis in rat adipocytes. II. Definition of steady-state relationship with lipolytic and antilipolytic modulators. J Biol Chem 260:15130-15138
38. Feingold KR, Doerrler W, Dinarello CA, Fiers W, Grunfeld C (1992) Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked inhibition of prostaglandin synthesis. Endocrinology 130: 10-16
39. Souza SC, de Vargas LM, Yamamoto MT, Lien P, Franciosa MD, Moss LG, Greenberg AS (1998) Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. J Biol Chem 273:24665-24669
40. Colucci-Guyon E, Portier MM, Dunia I, Paulin D, Pournin S, Babinet C (1994) Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell 79:679-694
41. Heid HW, Schnolzer M, Keenan TW (1996) Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. Biochem J 320:1025-1030