Accelerated cytotoxicity mechanism screening using drug metabolising enzyme modulators

Current Drug Metabolism

Volumn 6, Issue 2, 2005, Pages 101-109

  O'Brien, Peter J ^a   Siraki, A G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Arylamine N acetyltransferase; Coenzyme A transferases; Cytochrome P 450; Enzyme inhibitors; Glucuronosyltransferase; Glutathione transferase; Hepatotoxicity; Sulfotransferases

Indexed keywords

1 AMINOBENZOTRIAZOLE; CHLORAMPHENICOL; CIMETIDINE; CLOFIBRATE; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; CYTOTOXIC AGENT; DICLOFENAC; DRUG METABOLIZING ENZYME; ENZYME ACTIVATOR; ENZYME INHIBITOR; ERYTHROMYCIN; FURAFYLLINE; IMIPRAMINE; ISONIAZID; KETOCONAZOLE; METHOXSALEN; METYRAPONE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENOBARBITAL; QUINIDINE; QUININE; SALICYLAMIDE; SALICYLIC ACID; SULFAPHENAZOLE; TROLEANDOMYCIN; UNINDEXED DRUG; VALPROIC ACID; XENOBIOTIC AGENT;

ACETYLATION; CARCINOGENICITY; CELL ISOLATION; CELL VIABILITY; CYTOTOXICITY; DRUG ACTIVITY; DRUG CLEARANCE; DRUG DETOXIFICATION; DRUG EFFICACY; DRUG HYDROXYLATION; DRUG METABOLISM; GASTROINTESTINAL TOXICITY; HEPATOMA CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LIVER CELL; LIVER INJURY; LIVER MICROSOME; LIVER TOXICITY; METHYLATION; NONHUMAN; REVIEW; SCREENING; SULFATION; TRANSGENIC MOUSE;

ANIMALS; DRUG EVALUATION, PRECLINICAL; ENZYME INDUCTION; ENZYME INHIBITORS; HEPATOCYTES; HUMANS; PHARMACEUTICAL PREPARATIONS;

EID: 15444381338     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200053586082     Document Type: Review

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