Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 477, Issue 1-2, 2001, Pages 79-87

  Gonzalez, Frank J ^a   Kimura, Shioko ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Carcinogenesis; Cytochrome P450; Gene knockout; Xenobiotic

Indexed keywords

4 BIPHENYLAMINE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; BENZENE; CAFFEINE; CARCINOGEN; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2E1; DIMETHYL SULFOXIDE; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE; PARACETAMOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE QUINONE OXIDOREDUCTASE; SULFOTRANSFERASE; TRANSFERASE; UNCLASSIFIED DRUG;

BIOASSAY; BIOLOGICAL MODEL; BONE MARROW TOXICITY; CANCER RISK; CATALYSIS; CELL DEATH; CHEMICAL CARCINOGENESIS; DRUG METABOLISM; ENZYME ACTIVITY; GENE DISRUPTION; GENETIC POLYMORPHISM; GENOTOXICITY; HUMAN; KNOCKOUT GENE; KNOCKOUT MOUSE; LIVER NECROSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SPECIES DIFFERENCE; VALIDATION PROCESS; XENOBIOTIC METABOLISM;

ACETAMINOPHEN; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZ(A)ANTHRACENES; BENZENE; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; EPOXIDE HYDROLASES; HUMANS; MICE; MICE, KNOCKOUT; NEOPLASMS; XENOBIOTICS;

ANIMALIA; MAMMALIA; MUS MUSCULUS; RODENTIA;

EID: 0035796030     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00109-9     Document Type: Review

References (29)

1. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. P450 super family - update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 6:1996;1-42.
2. Gonzalez F.J., Nebert D.W. Evolution of the P450 gene superfamily - animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet. 6:1990;182-186.
3. Guengerich F.P. Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species. Chem. Biol. Interact. 106:1997;161-182.
4. Christou M., Savas U., Spink D.C., Gierthy J.F., Jefcoate C.R. Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells. Carcinogenesis. 15:1994;725-732.
5. F.P. Guengerich, W.G. Humphreys, C.H. Yun, G.J. Hammons, F.F. Kadlubar, Y. Seto, O. Okazaki, M.V. Martin, Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues, in: Proceedings of the Princess Takamatsu Symposium, Vol. 23, 1995 pp. 78-84.
6. Eaton D.L., Gallagher E.P., Bammler T.K., Kunze K.L. Role of cytochrome P4501A2 in chemical carcinogenesis - implications for human variability in expression and enzyme activity. Pharmacogenetics. 5:1995;259-274.
7. Guengerich F.P., Kim D.H., Iwasaki M. Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4:1991;168-179.
8. Hengstler J.G., Arand M., Herrero M.E., Oesch F. Polymorphisms of N-acetyltransferases, glutathione Stransferases, microsomal epoxide hydrolase and sulfotransferases - influence on cancer susceptibility. Recent Results Cancer Res. 154:1998;47-85.
9. Guengerich F.P. Epoxide hydrolase - properties and metabolic roles. Rev. Biochem. Toxicol. 4:1982;5-30.
10. Friedberg T., Becker R., Oesch F., Glatt H.R. Studies on the importance of microsomal epoxide hydrolase in the detoxification of arene oxides using the heterologous expression of the enzyme in mammalian cells. Carcinogenesis. 15:1994;171-175.
11. Phillips D.H., Grover P.L. Polycyclic hydrocarbon activation - bay regions and beyond. Drug Metab. Rev. 26:1994;443-467.
12. Gonzalez F.J., Idle J.R. Pharmacogenetic phenotyping and genotyping. Present status and future potential. Clin. Pharmacokinet. 26:1994;59-70.
13. Caporaso N., Goldstein A. Cancer genes: single and susceptibility - exposing the difference. Pharmacogenetics. 5:1995;59-63.
14. Waxman D.J. Interactions of hepatic cytochromes P450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P450 enzyme expression. Biochem. Pharmacol. 37:1988;71-84.
15. Strott C.A. Steroid sulfotransferases. Endocr. Rev. 17:1996;670-697.
16. Pineau T., Fernandez-Salguero P., Lee S.S., McPhail T., Ward J.M., Gonzalez F.J. Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2. Proc. Natl. Acad. Sci. U. S. A. 92:1995;5134-5138.
17. Buters J.T., Sakai S., Richter T., Pineau T., Alexander D.L., Savas U., Doehmer J., Ward J.M., Jefcoate C.R., Gonzalez F.J. Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas. Proc. Natl. Acad. Sci. U. S. A. 96:1999;1977-1982.
18. Lee S.S., Buters J.T., Pineau T., Fernandez-Salguero P., Gonzalez F.J. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J. Biol. Chem. 271:1996;12063-12067.
19. Butler M.A., Iwasaki M., Guengerich F.P., Kadlubar F.F. Human cytochrome P450PA (P450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Biochemistry. 86:1989;7696-7700.
20. Gu L., Gonzalez F.J., Kalow W., Tang B.K. Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1. Pharmacogenetics. 2:1992;73-77.
21. Buters J.T., Tang B.K., Pineau T., Gelboin H.V., Kimura S., Gonzalez F.J. Role of CYP1A2 in caffeine pharmacokinetics and metabolism - studies using mice deficient in CYP1A2. Pharmacogenetics. 6:1996;291-296.
22. Butler M.A., Lang N.P., Young J.F., Caporaso N.E., Vineis P., Hayes R.B., Teitel C.H., Massengill J.P., Lawsen M.F., Kadlubar F.F. Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics. 2:1992;116-127.
23. Tang B.K., Kalow W. Assays for CYP1A2 by testing in vivo metabolism of caffeine in humans. Methods Enzymol. 272:1996;124-131.
24. Holtzman J.L. The role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen. Drug. Metab. Rev. 27:1995;277-297.
25. Prasad J.S., Chen N.Q., Liu Y.X., Goon D.J., Holtzman J.L. Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats. Biochem. Pharmacol. 40:1990;1989-1995.
26. Zaher H., Buters J.T., Ward J.M., Bruno M.K., Lucas A.M., Stern S.T., Cohen S.D., Gonzalez F.J. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double- null mice. Toxicol. Appl. Pharmacol. 152:1998;193-199.
27. Valentine J.L., Lee S.S., Seaton M.J., Asgharian B., Farris G., Corton J.C., Gonzalez F.J., Medinsky M.A. Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol. Appl. Pharmacol. 141:1996;205-213.
28. Kimura S., Kawabe M., Ward J.M., Morishima H., Kadlubar F.F., Hammons G.J., Fernandez-Salguero P., Gonzalez F.J. CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. Carcinogenesis. 20:1999;1825-1830.
29. Miyata M., Kudo J., Lee Y.H., Yang T.J., Gelboin H.V., Fernandez-Salguero P., Kimura S., Gonzalez F.J. Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. J. Biol. Chem. 274:1999;23963-23968.