Bioactivation and cytotoxicity of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) in isolated rat hepatocytes

Pharmacology and Toxicology

Volumn 88, Issue 4, 2001, Pages 192-197

  Ferrara, Roberta ^a   Zanovello, Alberta ^a   Bortolato, Silvia ^a   White, Ian N H ^b   Manno, Maurizio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b MRC TOXICOLOGY UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DICHLORO 2,2,2 TRIFLUOROETHANE; 4 METHYLPYRAZOLE; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 INHIBITOR; ETHANE; ETHYLENE DERIVATIVE; FREE RADICAL; GLUTATHIONE; LACTATE DEHYDROGENASE; MALEIC ACID DIETHYL ESTER; METYRAPONE; N TERT BUTYL ALPHA PHENYLNITRONE; PHORONE; TROLEANDOMYCIN;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GAS CHROMATOGRAPHY; HYPOXIA; LIVER CELL; MALE; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; TOXICOKINETICS; XENOBIOTIC METABOLISM;

ANIMALS; CHLOROFLUOROCARBONS; DOSE-RESPONSE RELATIONSHIP, DRUG; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE; HALOTHANE; HEPATOCYTES; KETONES; L-LACTATE DEHYDROGENASE; MALE; MALEATES; NITROGEN OXIDES; PYRAZOLES; PYRIDINES; RATS; RATS, WISTAR; TROLEANDOMYCIN;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0035044205     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.2001.880406.x     Document Type: Article

References (5)

1. Albano, E., K. A. K. Lott, T. F. Slater, A. Stier, M. C. R. Symons & A. Tomasi: Spin-trapping studies on the free radical products formed by metabolic activation of carbon tetrachloride in rat liver microsomal fractions, isolated hepatocytes and in vivo in the rat. Biochem. J. 1982, 204, 593-603.
2. Anders, M. W.: Metabolism and toxicity of hydrochlorofluorocarbons: current knowledge and needs for the future. Envronm. Health Perspect. 1991, 96, 185-191.
3. ECETOC: 1,1-Dichloro-2,2,2-trifluoroethane (HCFC-123). In: Joint assessment of commodity chemicals no. 33. ECETOC, Brussels, 1996, pp. 1-55.
4. Ferrara, R., R. Tolando, L. J. King & M. Manno: Cytochrome P450 inactivation during reductive metabolism of 1,1-dichloro2,2,2-trifluoroethane (HCFC-123) by phenobarbital- and pyridine-induced rat liver microsomes. Toxicol Appl. Pharmacol. 1997, 143, 420-428.
5. 2 on the toxicity of HCFC-123, HCFC-141b and halothane in rat hepatocytes. Toxicol. Lett. 1996, 88 Suppl. 1, 43.