Imipramine- and mianserin-induced acute cell injury in primary cultured rat hepatocytes: Implication of different cytochrome P450 enzymes

Archives of Toxicology

Volumn 73, Issue 3, 1999, Pages 147-151

  Masubuchi, Yasuhiro ^a   Konishi, Maki ^a   Horie, Toshiharu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Cytochrome P450 Hepatotoxicity; Hepatocytes; Imipramine; Mianserin

Indexed keywords

CYTOCHROME P450; GLUTATHIONE; IMIPRAMINE; LACTATE DEHYDROGENASE; MIANSERIN; THIOL DERIVATIVE;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LEVEL; CYTOTOXICITY; FEMALE; LIVER CELL; LIVER CELL DAMAGE; LIVER METABOLISM; LIVER MICROSOME; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; STRAIN DIFFERENCE;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GLUTATHIONE; IMIPRAMINE; L-LACTATE DEHYDROGENASE; LIVER; MALE; MIANSERIN; RATS; RATS, WISTAR; SEX FACTORS; SULFHYDRYL COMPOUNDS;

AGOUTI; ANIMALIA; RATTUS NORVEGICUS;

EID: 0033003243     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050599     Document Type: Article

References (28)

1. Abernathy C, Lukacs L, Zimmerman H (1975) Toxicity of tricyclic antidepressants to isolated rat hepatocytes. Biochem Pharmacol 24: 347-350
2. Brøsen K, Zeugin T, Meyer UA (1991) Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine. Clin Pharmacol Ther 49: 609-617
3. Di Monte D, Ross D, Bellomo G, Eklow L, Orrenius S (1984) Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch Biochem Biophys 235: 334-342
4. Dingell J, Sulser F, Gillette J (1964) Species differences in the metabolism of imipramine and desmethy imipramine (DMI). J Pharmacol Exp Ther 143: 14-22
5. Fujita S, Morimoto R, Chiba M, Kitani K, Suzuki T (1989) Evaluation of the involvement of a male specific cytochrome P-450 isozyme in senescence-associated decline of hepatic drug metabolism in male rats. Biochem Pharmacol 38: 3925-3931
6. 14C]imipramine with rat and human liver microsomes. Biochem Pharmacol 34: 1079-1084
7. Keller D, Menzel D (1985) Picomole analysis of glutathione, glutathione disulfide, glutathione S-sulfonate, and cysteine S-sulfonate by high-performance liquid chromatography. Anal Biochem 151:418-423
8. Koyama E, Chiba K, Tani M, Ishizaki T (1996) Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers. J Pharmacol Exp Ther 278: 21-30
9. Lambert C, Park B, Kitteringham N (1989) Activation of mianserin and its metabolites by human liver microsomes. Biochem Pharmacol 38: 2853-2858
10. Masubuchi Y, Umeda S, Chiba M, Fujita S, Suzuki T (1991) Selective 3-hydroxylation deficiency of lidocaine and its metabolite in Dark Agouti rats. Biochem Pharmacol 42: 693-695
11. Masubuchi Y, Kagimoto N, Narimatsu S, Fujita S, Suzuki T (1993) Regioselective contribution of the cytochrome P-450 2D subfamily to propranolol metabolism in rat liver microsomes. Drug Metab Dispos 21: 1012-1016
12. Masubuchi Y, Takahashi C, Fujio N, Horie T, Suzuki T, Imaoka S, Funae Y, Narimatsu S (1995) Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats. Drug Metab Dispos 23: 999-1003
13. Masubuchi Y, Igarashi S, Suzuki T, Horie T, Narimatsu S (1996) Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate. J Pharmacol Exp Ther 279: 724-731
14. Matsunaga E, Zanger UM, Hardwick JP, Gelboin HV, Meyer UA, Gonzalez FJ (1989) The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. Biochemistry 28: 7349-7355
15. Mitchell D, Acosta D (1981) Evaluation of the cytotoxicity of tricyclic antidepressants in primary cultures of rat hepatocytes. J Toxicol Environ Health 7: 83-92
16. Moldeus P, Hogberg J, Orrenius S (1978) Isolation and use of liver cells. Methods Enzymol 52: 60-71
17. Moskovitz R, DeVane C, Harris R, Stewart R (1982) Toxic hepatitis and single daily dosage imipramine therapy. J Clin Psychiatry 43: 165-166
18. Otani K, Kaneko S, Tasaki H, Fukushima Y (1989) Hepatic injury caused by mianserin. Br Med J 299: 519
19. Pessayre D (1995) Role of reactive metabolites in drug-induced hepatitis. J Hepatol 23: 16-24
20. Powell WJ, Koch-Weser J, Williams R (1968) Lethal hepatic necrosis after therapy with imipramine and desipramine. J Am Med Assoc 206: 642-645
21. Riley RJ, Roberts P, Kitteringham NR, Park BK (1990) Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes. Biochem Pharmacol 39: 1951-1958
22. Roberts P, Kitteringham N, Park B (1991) Species differences in the activation of mianserin to a cytotoxic metabolite. Drug Metab Dispos 19: 841-843
23. Sallee F, Pollock B (1990) Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet 18: 346-364
24. Short M, Burns J, Harris M (1968) Cholestatic jaundice during imipramine therapy. J Am Med Assoc 206: 1791-1792
25. Soucek P, Gut I (1992) Cytochromes P-450 in rats: structures, functions, properties and relevant human forms. Xenobiotica 22: 83-103
26. Urbain D, Rodzynek J, Wettendorff P, Meyer P, Delcourt A (1985) Hepatic toxicity of mianserin. Rev Med Brux 6: 39-40
27. Wroblewski F, La Due JS (1955) Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med 90: 210-213
28. Yamamoto Y, Tasaki T, Nakamura A, Iwata H, Kazusaka A, Gonzalez F, Fujita S (1998) Molecular basis of the Dark Agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2. Pharmacogenetics 8: 73-82