Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene

Chemico-Biological Interactions

Volumn 147, Issue 2, 2004, Pages 173-184

  Maggs, James L ^a   Bishop, Laurence P D ^a,e   Batty, Kevin T ^b   Dodd, Charlotte C ^a   Ilett, Kenneth F ^c   O'Neill, Paul M ^a   Edwards, Geoffrey ^a,d   Kevin Park, B ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b CURTIN UNIVERSITY   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^e Department of Genetic and Molecular Toxicology   (United Kingdom)

Author keywords

3 (4,5 dimethylthiazol 2 yl) 2,5 diphenyltetrazolium bromide; Arteflene; Dimethyl sulphoxide; DMSO; Hepatocytes; High performance liquid chromatography; HPLC; IPRL; Isolated perfused rat liver; LC MS; Liquid chromatography mass spectrometry; MTT

Indexed keywords

8 HYDROXYARTEFLENE GLUCURONIDE; ANTIMALARIAL AGENT; ARTEFLENE; CARBON 14; DRUG METABOLITE; ENZYME; GLUCURONIDE; OXIDOREDUCTASE; RADICAL; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE; CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG METABOLISM; ENZYME ACTIVITY; INCUBATION TIME; ISOLATED LIVER; LIVER CELL; LIVER METABOLISM; LIVER PERFUSION; MALE; NONHUMAN; RADIOACTIVITY; RAT;

ANIMALS; ANTIMALARIALS; ARTEMISININS; BICYCLO COMPOUNDS, HETEROCYCLIC; BILE; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HEPATOCYTES; LIVER; MALE; PERFUSION; RATS; RATS, WISTAR; STYRENES;

EID: 1542346130     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2003.12.005     Document Type: Article

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