Metabolism of the antimalarial endoperoxide Ro 42-1611 (Arteflene) in the rat: Evidence for endoperoxide bioactivation

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 1, 1999, Pages 511-520

  Bishop, Laurence P D ^a   Maggs, James L ^a   O'Neill, Paul M ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEFLENE; ARTEMISININ; CYTOCHROME P450; DIMETHYL SULFOXIDE; ENDOPEROXIDE; IRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; DRUG ACTIVATION; DRUG ACTIVITY; DRUG DEGRADATION; DRUG METABOLISM; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIVER MICROSOME; MALARIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS;

ANIMALS; ANTIMALARIALS; ARTEMISININS; BICYCLO COMPOUNDS, HETEROCYCLIC; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONATES; GLUTATHIONE; HUMANS; KETOCONAZOLE; KETONES; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; PEROXIDES; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ULTRAVIOLET; STYRENES;

EID: 0032947034     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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