Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

British Journal of Pharmacology

Volumn 125, Issue 1, 1998, Pages 159-167

  Batty, Kevin T ^a,e   Ilett, Kenneth F ^a,b   Edwards, Geoffrey ^c,d   Powell, Shane M ^a   Maggs, James L ^c   Park, B Kevin ^c   Davis, Timothy M E ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b W Australian Inst Pathol Med R   (Australia)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^e CURTIN UNIVERSITY   (Australia)

Author keywords

Bioavailability; Dihydroartemisinin; Isolated perfused rat liver; Malaria; Metabolism; Pharmacokinetics

Indexed keywords

ANTIMALARIAL AGENT; DIHYDROARTEMISININ; DRUG METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; FLOW RATE; ISOLATED LIVER; LIVER CLEARANCE; LIVER MICROSOME; LIVER PERFUSION; MALARIA; MALE; NONHUMAN; PERFUSION; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIMALARIALS; ARTEMISININS; BILIARY TRACT; GLUCURONATES; MALARIA; MALE; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; PERFUSION; RATS; RATS, WISTAR; SESQUITERPENES;

EID: 0031679973     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702023     Document Type: Article

References (51)

1. BATTY, K.T., DAVIS, T.M.E., THU, L.T., BINH, T.Q., ANH, T.K. & ILETT, K.F. (1996). Selective high-performance liquid chromatographic determination of artesunate and α- and β-dihydroartemisinin in patients with falciparum malaria. J. Chromatogr. B., 677, 345-350.
2. BATTY, K.T., THU, L.T., DAVIS, T.M.E., ILETT, K.F., MAI, T.X., HUNG, N.C., TIEN, N.P., POWELL, S.M., THIEN, H.V., BINH, T.Q. & KIM, N.V. (1998a). A pharmacokinetic and pharmacodynamic study of intravenous versus oral artesunate in uncomplicated falciparum malaria. Br. J. Clin. Pharmacol., 45, 123-130.
3. BATTY, K.T., THU, L.T.A., ILETT, K.F., TIEN, N.P., POWELL. S.M., HUNG, N.C., MAI, T.X., CHON, V.V., THIEN, H.V., BINH, T.Q., KIM, N.V. & DAVIS, T.M.E. (1998b). A pharmacokinetic and pharmacodynamic study of artesunate in vivax malaria. Am. J. Trop. Med. Hyg., (In Press)
4. BENAKIS, A., PARIS, M., LOUTAN, L., PLESSAS, C.T. & PLESSAS, S.T. (1997). Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers. Am. J. Trop. Med. Hyg., 56, 17-23.
5. BETHELL, D.B., TEJA-ISAVADHARM, P., CAO, X.T., PHAM, T.T., TA, T.T., TRAN, T.N., NGUYEN, T.T., PHAM, T.P., KYLE, D., DAY, N.P. & WHITE, N.J. (1997). Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria. Trans. R. Soc. Trop. Med. Hyg., 91, 195-198.
6. BOUDREAU, E.V., FLECKENSTEIN, L., PANG, L.W., CHILDS, G.E., SCHROEDER, A.C., RATNARATORN, B. & PHINTUYOTHIN, P. (1990). Mefloquine kinetics in cured and recrudescent patients with acute falciparum malaria and in healthy volunteers. Clin. Pharmacol. Ther., 48, 399-409.
7. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
8. BURCHELL, B. & COUGHTRIE, M.W. (1989). UDP-glucuronosyltransferases. Pharmacol. Ther., 43, 261-289.
9. CHEUNG, K., HICKMAN, P.E., POTTER, J.M., WALKER, N.I., JERICHO, M., HASLAM, R. & ROBERTS, M.S. (1996). An optimized model for rat liver perfusion studies. J. Surg. Res., 66, 81-89.
10. DE VRIES, P.J. & DIEN, T.K. (1996). Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria. Drugs, 52, 818-836.
11. FRANCIS, N. & WARRELL, D.A. (1993). Pathology and pathophysiology of human malaria. In Bruce-Chwatts Essential Malariology (3rd edn.). ed. Gilles, H.M. & Warrell, D.A. pp. 50-59. London: Edward Arnold.
12. GARNHAM, P.C.C. (1966). Rodent species of malaria parasites. In Malaria parasites and other haemosporidia. ed. Garnham, P.C.C. pp. 431-475. Oxford: Blackwell.
13. GLAZIER, A.P., KOKWARO, G.O., ISMAIL, S. & EDWARDS, G. (1994). Effect of an experimental malaria infection on the metabolism of phenacetin in the rat isolated perfused liver. Xenobiotica, 24, 785-793.
14. GORES, G.J., KOST, L.J. & LARUSSO, N.F. (1986). The isolated perfused rat liver: conceptual and practical considerations. Hepatology, 6, 511-517.
15. HEINZEL, G., WOLOSZCZAK, R. & THOMANN, P. (1993). Topfit Version 2.0; Pharmacokinetic and Pharmacodynamic Data Analysis System for the PC. Stuttgart: Gustav Fischer.
16. HIEN, T.T. & WHITE, N.J. (1993). Qinghaosu. Lancet, 341, 603-608.
17. HOUSTON, J.B. (1994). Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem. Pharmacol., 47, 1469-1479.
18. ISMAIL, S., KOKWARO, G.O., BACK, D.J. & EDWARDS, G. (1994). Effect of malaria infection on the pharmacokinctics of paracetamol in rat. Xenobiotica, 24, 527-533.
19. JONES, D.B., MIHALY, G.W., SMALLWOOD, R.A., WEBSTER, L.K., MORGAN, D.J. & MADSEN, N.P. (1984). Differential effects of hypoxia on the disposition of propranolol and sodium taurocholate by the isolated perfused rat liver. Hepatology, 4, 461-466.
20. KARHWANG, J. & WHITE, N.J. (1990). Clinical pharmacokinetics of mefloquine. Clin. Pharmacokinet., 19, 264-279.
21. KLAASSEN, C.D. & WATKINS, J.B. (1984). Mechanisms of bile formation, hepatic uptake, and biliary excretion. Pharmacol. Rev., 36, 1-67.
22. KLAYMAN, D.L. (1985). Qinghaosu (artemisinin): an antimalarial drug from China. Science, 228, 1049-1055.
23. LEE, I.S. & HUFFORD, C.D. (1990). Metabolism of antimalarial sesquiterpene lactones. Pharmacol. Ther., 48, 345-355.
24. LESKOVAC, V. & THEOHARIDES, A.D. (1991). Hepatic metabolism of artemisinin drugs-I. Drug metabolism in rat liver microsomes. Comp. Biochem. Physiol. [C], 99, 383-390.
25. LOOAREESUWAN, S., WILAIRATANA, P., VANIJANONTA, S., PITISUTTITHUM, P., VIRAVAN, C & KRAISINTU, K. (1996). Treatment of acute, uncomplicated, falciparum malaria with oral dihydroartemisinin. Ann. Trop. Med. Parasitol., 90, 21-28.
26. MADDEN, S., MAGGS, J.L. & PARK, B.K. (1996). Bioactivation of carbamazepine in the rat in vivo: evidence for the formation of a reactive arene oxides(s). Drug. Metab. Dispos., 24, 469-479.
27. MAGGS, J.L., MADDEN, S., BISHOP, L.P., O'NEILL, P.M. & PARK, B.K. (1997). The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide. Drug. Metab. Dispos., 25, 1200-1204.
28. MANSOR, S.M., WARD, S.A., EDWARDS, G., HOAKSEY, P.E. & BRECKENRIDGE, A.M. (1990). The effect of malaria infection on the disposition of quinine and quinidine in the rat isolated perfused liver preparation. J. Pharm. Pharmacol., 42, 428-432.
29. MAZEL, P. (1971). Experiments illustrating drug metabolism in vitro. In Fundamentals of Drug Metabolism and Drug Disposition. ed. La Du, B.N., Mandel. H.G. & Way, E.L. pp. 546-582. Baltimore: Williams & Wilkins.
30. MCCARTHY, J.S., FURNER, R.L., VAN DYKE, K. & STITZEL, R.E. (1970). Effects of malarial infection on host microsomal drug-metabolizing enzymes. Biochcm. Pharmacol., 19, 1341-1349.
31. MCMANUS, M.E. & ILETT, K.F. (1976). Mixed function oxidase activity in a marsupial, the quokka (Setonix brachyurus). Drug. Metab. Dispos., 4, 199-202.
32. MEIJER, D.K., KEULEMANS, K. & MULDER, G.J. (1981). Isolated perfused rat liver technique. Meth. Enzymol., 77, 81-94.
33. MIHALY, G.W., DATE, N.M., IRETON, H.J. & SMALLWOOD, R.A. (1987). The effect of malaria infection on primaquine elimination in the isolated perfused rat liver. Biochem. Pharmacol., 36, 225-228.
34. MILLER, L.L. (1973). Technique of isolated rat liver perfusion. In Isolated Liver Perfusion and its Applications. ed. Bartosek, I., Guaitani, A. & Miller, L.L. pp. 11-52. New York: Raven.
35. MINERS, J.O. & MACKENZIE, P.I. (1991). Drug glucuronidation in humans. Pharmacol. Ther., 51, 347-369.
36. MULDER, G.J. (1992). Glucuronidation and its role in regulation of biological activity of drugs. Ann. Rev. Pharmacol. Toxicol., 32, 25-49.
37. MURDOCH, R.T., GHABRIAL, H., MIHALY, G.W., MORGAN, D.J. & SMALLWOOD, R.A. (1991). Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver. Xenobiotica, 21, 1571-1582.
38. MURDOCH, R.T., GHABRIAL, H., SMALLWOOD, R.A. & MORGAN, D.J. (1992). Effect of malaria on phenol conjugation pathways in perfused rat liver. Biochem. Pharmacol., 43, 1229-1234.
39. NIU, X.Y., HO, L.Y., REN, Z.H. & SONG, Z.Y. (1985). Metabolic fate of Qinghaosu in rats; a new TLC densitometric method for its determination in biological material. Eur. J. Drug. Metab. Pharmacokinel., 10, 55-59.
40. OMURA, T. & SATO, R. (1964). The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem., 239, 2370-2378.
41. QUINTON, A., LEBEDEV, G., YOUTZ, P., TUERKE, T., SINKLER, R. & KUO, J. (1995). SigmaStat Version 2.0. San Rafael: Jandel Scientific.
42. RILEY, M.V. & DEEGAN, T. (1960). The effect of Plasmodium berghei on mouse-liver mitochondria. Biochem. J., 76, 41-46.
43. ROSEN, S., ROYCROFT, D.W., HANO, J.E. & BARRY, K.G. (1967). The liver in malaria. Electron microscopic observations on a hepatic biopsy obtained 15 minutes post mortem. Arch. Pathol., 83, 271-277.
44. ROWLAND, M. & TOZER, T.N. (1995). Clinical Pharmacokinetics: Concepts and Applications (3rd ed.). Philadelphia: Williams & Wilkins.
45. SEIVERD, C.E. (1983). Haematology for Medical Technologists (5th ed.). Philadelphia: Lea & Febiger.
46. SMALLWOOD, R.H., MIHALY, G.W., SMALLWOOD, R.A. & MORGAN, D.J. (1988). Propranolol elimination as described by the venous equilibrium model using flow perturbations in the isolated perfused rat liver. J. Pharm. Sci., 77, 330-333.
47. ST-PIERRE, M.V., SCHWAB, A.J., GORESKY, C.A., LEE, W.F. & PANG, K.S. (1989). The multiple-indicator dilution technique for characterization of normal and retrograde flow in once-through rat liver perfusions. Hepatology, 9, 285-296.
48. WARRELL, D.A., MOLYNEUX, M.E. & BEALES, P.F. (1990). Severe and complicated malaria. Trans. R. Soc. Trop. Med. Hyg., 84 Suppl 2, 1-65.
49. WHITE, N.J., LOOAREESUWAN, S., WARRELL, D.A., WARRELL, M.J., BUNNAG, D. & HARINASUTA, T. (1982). Quinine pharmacokineties and toxicity in cerebral and uncomplicated falciparum malaria. Am. J. Med., 73, 564-572.
50. WORLD HEALTH ORGANIZATION. (1995). WHO Model Prescribing Information: Drugs used in Parasitic Diseases (2nd edn.). Geneva: WHO.
51. ZAKIM, D. & DANNENBERG, A.J. (1992). How does the microsomal membrane regulate UDP-glucuronosyltransferases? Biochem. Pharmacol., 43, 1385-1393.