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Volumn 29, Issue 4, 1999, Pages 349-360

Intracellular localization and metabolism of the phenanthridinium trypanocide, ethidium bromide, by isolated rat hepatocytes

Author keywords

[No Author keywords available]

Indexed keywords

3 N GLUCURONOSYLETHIDIUM; 3,8 DIACETYLETHIDIUM; 8 N GLUCURONOSYLETHIDIUM; ANTITRYPANOSOMAL AGENT; ETHIDIUM BROMIDE; PHENANTHRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0032939943     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982599238551     Document Type: Article
Times cited : (17)

References (22)
  • 1
    • 0003156222 scopus 로고
    • The search for new trypanocides. Part VIII. Coupling of m-amidinobenzenediazonium chloride with 3,8-diamino-5-ethyl-6-phenylphenanthridinium chloride
    • BERG, S. S., 1963, The search for new trypanocides. Part VIII. Coupling of m-amidinobenzenediazonium chloride with 3,8-diamino-5-ethyl-6-phenylphenanthridinium chloride. Journal of the Chemical Society, 3635-3640.
    • (1963) Journal of the Chemical Society , pp. 3635-3640
    • Berg, S.S.1
  • 2
    • 0015474830 scopus 로고
    • Mitochondrial nucleic acids
    • BORST, P., 1972, Mitochondrial nucleic acids. Annual Review of Biochemistry, 41, 333-376.
    • (1972) Annual Review of Biochemistry , vol.41 , pp. 333-376
    • Borst, P.1
  • 3
    • 0000139091 scopus 로고
    • A new coupling component for sulphanilamide determination
    • BRATTON, C. A. and MARSHALL, E. K., 1939, A new coupling component for sulphanilamide determination. Journal of Biological Chemistry, 128, 537-550.
    • (1939) Journal of Biological Chemistry , vol.128 , pp. 537-550
    • Bratton, C.A.1    Marshall, E.K.2
  • 4
    • 0022592803 scopus 로고
    • Characteristics of ethidium uptake by the Trypanosomatid flagellates. Crithidia fasciculata and Leptomonas seymouri
    • COOLBEAR, K. P. and MIDGLEY, M., 1986, Characteristics of ethidium uptake by the Trypanosomatid flagellates, Crithidia fasciculata and Leptomonas seymouri. Antimicrobial Agents and Chemotherapy, 29, 258-262.
    • (1986) Antimicrobial Agents and Chemotherapy , vol.29 , pp. 258-262
    • Coolbear, K.P.1    Midgley, M.2
  • 5
    • 0015402532 scopus 로고
    • Collagen substrata for studies on cell behaviour
    • ELSDALE, T. and BARD, J., 1972, Collagen substrata for studies on cell behaviour. Journal of Cell Biology, 54, 626-637.
    • (1972) Journal of Cell Biology , vol.54 , pp. 626-637
    • Elsdale, T.1    Bard, J.2
  • 6
    • 0000347565 scopus 로고
    • Synthesis and characterization of ethidium analogs: Emphasis on amino and azido substituents (1)
    • FIRTH, W. J., WATKINS, C. L., GRAVES, D. E. and YIELDING, L. W., 1983, Synthesis and characterization of ethidium analogs: emphasis on amino and azido substituents (1). Heterocyclic Chemistry, 20, 759-765.
    • (1983) Heterocyclic Chemistry , vol.20 , pp. 759-765
    • Firth, W.J.1    Watkins, C.L.2    Graves, D.E.3    Yielding, L.W.4
  • 8
    • 0019890654 scopus 로고
    • Chemical structure of ethidium bromide metabolites extracted from rat bile
    • GAUGAIN, B., FRAIRE, C., LECOINTE, P., PAOLETTI, C. and ROQUES, B. P., 1981, Chemical structure of ethidium bromide metabolites extracted from rat bile. FEBS Letters, 129, 70-76.
    • (1981) FEBS Letters , vol.129 , pp. 70-76
    • Gaugain, B.1    Fraire, C.2    Lecointe, P.3    Paoletti, C.4    Roques, B.P.5
  • 9
    • 0020447520 scopus 로고
    • Ethidium bromide: Pharmacokinetics and efficacy against trypanosome infections in rabbits and calves
    • GILBERT, R. J. and NEWTON, B. A., 1982, Ethidium bromide: pharmacokinetics and efficacy against trypanosome infections in rabbits and calves. Parasitology, 85, 127-148.
    • (1982) Parasitology , vol.85 , pp. 127-148
    • Gilbert, R.J.1    Newton, B.A.2
  • 10
    • 0013534674 scopus 로고
    • The metabolism of ethidium in normal and neoplastic tissues
    • KANDANSWAMY, T. S. and HENDERSON, J. F., 1963, The metabolism of ethidium in normal and neoplastic tissues. Cancer Research, 23, 250-253.
    • (1963) Cancer Research , vol.23 , pp. 250-253
    • Kandanswamy, T.S.1    Henderson, J.F.2
  • 11
    • 0023478743 scopus 로고
    • Binding of isometamdium to calf thymus DNA and lipids: Pharmacological implications
    • KINABO, L. D. B. and BOGAN, J. A., 1987, Binding of isometamdium to calf thymus DNA and lipids: pharmacological implications. Journal of Veterinary Pharmacology and Therapeutics, 10, 357-362.
    • (1987) Journal of Veterinary Pharmacology and Therapeutics , vol.10 , pp. 357-362
    • Kinabo, L.D.B.1    Bogan, J.A.2
  • 13
    • 0019383731 scopus 로고
    • Present status of chemotherapy and chemoprophylaxis of animal trypanosomiasis in the eastern hemisphere
    • LEACH, T. M. and ROBERTS, C. L., 1981, Present status of chemotherapy and chemoprophylaxis of animal trypanosomiasis in the eastern hemisphere. Pharmacology and Therapeutics, 13, 91-147.
    • (1981) Pharmacology and Therapeutics , vol.13 , pp. 91-147
    • Leach, T.M.1    Roberts, C.L.2
  • 14
    • 0019486239 scopus 로고
    • The hepatic metabolism of ethidium bromide to reactive mutagenic species: Biochemical and structural requirements
    • LECOINTE, P., BICHET, N., FRAIRE, C. and PAOLETTI, C., 1981, The hepatic metabolism of ethidium bromide to reactive mutagenic species: biochemical and structural requirements. Biochemical Pharmacology, 30, 601-609.
    • (1981) Biochemical Pharmacology , vol.30 , pp. 601-609
    • Lecointe, P.1    Bichet, N.2    Fraire, C.3    Paoletti, C.4
  • 15
    • 0015139166 scopus 로고
    • Metabolism and biliary excretion of phenanthridinium salts - 1. Nature of the biliary metabolites
    • MACGREGOR, J. T. and CLARKSON, T. W., 1971, Metabolism and biliary excretion of phenanthridinium salts - 1. Nature of the biliary metabolites. Biochemical Pharmacology, 20, 2833-2846.
    • (1971) Biochemical Pharmacology , vol.20 , pp. 2833-2846
    • MacGregor, J.T.1    Clarkson, T.W.2
  • 18
    • 0023100602 scopus 로고
    • Application of isolated hepatocytes to studies of drug metabolism in large food animals
    • SHULL, L. R., KIRSCH, D. G., LOHSE, C. L. and WISNIEWSKI, J. A., 1987, Application of isolated hepatocytes to studies of drug metabolism in large food animals. Xenobiotica, 17, 345-363.
    • (1987) Xenobiotica , vol.17 , pp. 345-363
    • Shull, L.R.1    Kirsch, D.G.2    Lohse, C.L.3    Wisniewski, J.A.4
  • 20
    • 0002223573 scopus 로고
    • Researches in the phenanthridinium series. Part VI. The relationship between structure and trypanocidal properties
    • WALLS, L. P., 1945, Researches in the phenanthridinium series. Part VI. The relationship between structure and trypanocidal properties. Journal of the Chemical Society, 294-300.
    • (1945) Journal of the Chemical Society , pp. 294-300
    • Walls, L.P.1
  • 21
    • 0028949538 scopus 로고
    • Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis
    • WANG, C. C., 1995, Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis. Annual Review of Pharmacology and Toxicology, 35, 93-127.
    • (1995) Annual Review of Pharmacology and Toxicology , vol.35 , pp. 93-127
    • Wang, C.C.1
  • 22
    • 0013534675 scopus 로고
    • Cross-linking and intercalation in nucleic acids
    • B. A. Newton and P. E. Reynolds (eds), London: Cambridge University Press
    • WARING, M. J., 1966, Cross-linking and intercalation in nucleic acids. In B. A. Newton and P. E. Reynolds (eds), Biochemical Studies of Antimicrobial Drugs (London: Cambridge University Press), pp. 235-265.
    • (1966) Biochemical Studies of Antimicrobial Drugs , pp. 235-265
    • Waring, M.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.