The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro

Biochemical Pharmacology

Volumn 61, Issue 4, 2001, Pages 409-416

  Smith, Sharon L ^a   Sadler, Claire J ^a   Dodd, Charlotte C ^a   Edwards, Geoffrey ^b   Ward, Stephen A ^a   Park, B Kevin ^a   McLean, W Graham ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Antioxidant; Artemisinin; Free radical; Glutathione; Malaria; Neurotoxicity

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; ARTEMETHER; ARTEMISININ DERIVATIVE; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; CATALASE; CYSTEINE; DIHYDROARTEMISININ; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEMIN; SUPEROXIDE DISMUTASE;

ANALYTIC METHOD; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN DEPLETION; TOXICITY;

ANIMALS; ANTIMALARIALS; ANTIMETABOLITES; ANTIOXIDANTS; ARTEMISININS; BUTHIONINE SULFOXIMINE; DRUG INTERACTIONS; GLUTATHIONE; HEMIN; HUMANS; MICE; NEURITES; SESQUITERPENES; TUMOR CELLS, CULTURED;

EID: 0035865310     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00556-6     Document Type: Article

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