Parameters controlling topical delivery of oligonucleotides by electroporation

Journal of Drug Targeting

Volumn 5, Issue 4, 1998, Pages 275-289

  Regnier, V ^a   Le Doan, T ^b   Preat V ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Electroporation; Oligonucleotides; Skin permeation; Stability; Topical delivery

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG TARGETING; ELECTROPORATION; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY; TOPICAL DRUG ADMINISTRATION;

EID: 0031670292     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869808995881     Document Type: Article

References (43)

1. Akhtar, S., Kole. R. and Juliano, L. (1991) Stability of antisense DNA oligodeoxynucleotides analogs in cellular extracts and sera. Life Sciences, 49, 1793-1801.
2. Bazile, D., Mir. L. and Paoletti, C. (1989) Voltage dependant introduction of a d[α]octothymidilate into electropermeabilized cells. Biochem. Biophys. Res. Commun., 159, 633-9.
3. Belehradek, J. Jr, Orlowski. S., Ramirez, L.H., Pron, G., Poddevin, B. and Mir, L.M. (1994) Electropermeabilization of cells in tissues assessed by the qualitative and quantitative electroloading of bleomycin. Biochim. Biophys. Acta., 1190, 155-63.
4. Bergan, R., Connell, Y., Fahmy, B. and Neckers, L. (1993) Electroporation enhances c-myc antisense oligodeoxynucleotide efficacy. Nucleic. Acids. Res., 21, 3567-73.
5. Bommannan, D.B., Tamada, J., Leung, L. and Potts, R. (1994) Effect of electroporation on transdermal iontophoretic delivery of luteinising hormone releasing hormone (LHRH) in vitro. Pharm. Res., 11, 1809-1814.
6. Brand, R. and Iversen, P. (1996) Iontophoretic delivery of a telomeric oligonuclcotide. Pharm. Res., 13, 851-854.
7. Crooke, S. (1995) The future of antisense technology. Pharm. News, 2, 8-11.
8. Crooke, S. and Bennett, C.F. (1996) Progress in antisense oligonucleotide therapeutic. Annu. Pharmacol. Toxicol., 36, 107-129.
9. Edwards. D.A., Prausnitz, M.R., Langer, R. and Weaver. J.C. (1995) Analysis of enhanced transdermal transport by skin electroporation. J. Control. Rel., 34, 211-221.
10. Fynan, E.F., Webster, R.G., Fuller, D.H., Haynes, J.R., Santoro, J.C. and Robinson, H.L. (1993) DNA vaccines: protective immunizations by parenteral. mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA., 90, 11478-82.
11. Gillardon, F., Eschenfelder, C., Uhlmann, E., Hartschuh, W. and Zimmermann, M. (1994) Differential regulation of c-fos, c-jun, bcl-2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion. Oncogene, 9, 3219-3225.
12. Goodchild, J. (1989) Inhibition of gene expression by antisense oligonucleotides. In Cohcn. J.S. (ed.). Oligonucleotides: Antisense Inhibitors of Gene Expression (Boca Raton. CRC Press), pp 53-77.
13. Graham, M.J., Freier, S.M., Crooke, R.M., Eckler, D.J., Maslova, R.N. and Lesnik, E.A. (1993) Tritium labelling of antisense oligonucleotides by exchange with tritiated water. Nucleic Acids. Res., 21, 3737-3743.
14. Heller, R., Jaroszeski, M., Glass, L., Messina, J., Rapaport. D., Deconti, R., Fenske, N., Gilbert, R., Mir, L. and Reintgen, D. (1996) Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy. Cancer, 77, 964-971.
15. Jadoul A. (1997) Skin perturbations induced by iontophoresis and electroporation: enhancement in drug transport and integrity of the stratum corneum. PhD. Thesis. Université Catholique de Louvain, Brussels, Belgium.
16. Marks, R. and Barton, S.P. (1983) The significance of the size and shape of corneocytes. In Maecks, R. and Plewig, G. (eds). Stratum corneum (Berlin, Springer verlag), pp 161-170.
17. Nolen, III H.W., Catz, P. and Friend, D.R. (1994) Percutaneous penetration of methyl phosphonate antisense oligonucleotides. Int. J. Pharm., 107, 169-177.
18. Oldenburgh, K.R., Vo, K.T., Smith, G.A. and Selick, H.E. (1995) lontophoretic deliver) of oligonucleotides across full thickness hairless mouse skin. J. Pharm. Sci., 84, 915-21,
19. Pinkus, I. (1976) Anatomy and embryology of the skin. In Andrade R. (ed), Cancer of the Skin (Philadelphia. Saunders press), pp 16-89.
20. Pliquett, U. and Weaver, J.C. (1996) Electroporation of human skin: simultaneous measurement of changes in the transport of two fluorescent molecules and in the passive electrical properties. Bioelectrochem. Bioenerg., 39, 1-12.
21. Prausnitz, M., Bose, V., Langer, R. and Weaver, J. (1993) Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Nat. Acad. Sci. USA., 90. 10504-10508.
22. Prausnitz, M.R., Pliquett, U., Langer, R. and Weaver, J.C. (1994) Rapid temporal control of transdermal drug delivery by electroporation. Pharm. Res., 11, 1834-7.
23. Prausnitz, M.R., Edelman, E.R., Gimm, J.A., Langer, R. and Weaver, J.C. (1995) Transdermal Delivery of Heparin by Skin Electroporation. Bio-Technology. 13, 1205-1209.
24. Prausnitz, M. (1996) Transdermal transport efficiency during skin electroporation and iontophoresis. J. Control. Rel., 38, 205-217.
25. Regnier, V., Le Doan, T., Laurent, M. and Préat, V. (1996) Cutaneous delivery of oligonucleotides by electroporation. Pharm. Res., 13, S-383.
26. Roizman, B. (1992) Inhibition of Herpesviridae infection by antisense oligonucleotides. PCT WO 92/03051.
27. Rojanasakul, Y. (1996) Antisense oligonucleotide therapeutics: drug delivery and targeting. Adv. Drug Del. Rev., 18, 115-131.
28. Rols, M.P. and Teissié, J. (1990) Electropermeabilization of mammalian cells: quantitative analysis of the phenomenon. Biophys. J., 58, 1089-1098.
29. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular cloning: A laboratory manual (New-York. Cold Spring Harbor Laboratory Press), p B16.
30. Shin, B.C. and Lee, H.B. (1994) Iontophoretic delivery of insulin: effects of skin treatments. Proceed. Int. Symp. Control. Rel. Bioact. Mater., 21, 373-374.
31. Thysman, S., Préat. V. and Roland, M. (1991) Factors affecting iontophoretic mobility of metoprolol. J. Pharm. Sci., 81, 670-675.
32. Titomirov, A.V., Sukharev, S. and Kistanova, E. (1991) In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA. Biochim. Biophys. Acta., 1088, 131-134.
33. Tojo, K., Chiang, C., Doshi, U. and Chien, Y.W. (1988) Stratum corneum reservoir capacity affecting dynamics of transdermal drug delivery. Drug Dev. & Ind. Pharm., 14, 561-572.
34. Vanbever, R., Lecouturier, N. and Préat, V. (1994) Transdermal delivery of metoprolol by electroporation. Pharm. Res., 11, 1657-62.
35. Vanbever, R. and Préat, V. (1995) Factors affecting transdermal delivery of metoprolol by electroporation. Bioelectrochem. Bioenerget., 38, 223-228.
36. Vanbever, R., Le Boulangé. E. and Préat. V. (1996a) Transdermal delivery of fentanyl by electroporation I. Influence of electrical factors. Pharm. Res., 13, 557-563.
37. Vanbever, R., De Morre, N. and Préat. V. (1996b) Transdermal delivery of fentanyl by electroporation II. Mechanisms involved in drug transport. Pham. Res., 13, 1360-1366.
38. Vanbever, R. (1997) Skin electroporation for transdermal drug delivery. PhD. Thesis, Université Catholique de Louvain, Brussels, Belgium.
39. Vlassov, V., Nechaeva, M., Karamyshev, V. and Yakubov, L. (1994) lontophoretic delivery of oligonucleotide derivatives into mouse tumor. Antisense Res. Dev., 4, 291-293.
40. Weaver, J. (1995) Electroporation theory. Concepts and mechanisms. Methods. Mol. Biol., 47, 1-26.
41. Weaver, J. and Chizmadzhev, Y. (1996) Electroporation. in Polk, C. and Postow, E. (eds). CRC Handbook of biological effects of electromagnetic fields (Boca Raton, CRC Press, Second Edition), pp 247-274.
42. Zewert, T.E., Pliquett, U.F., Langer, R. and Weaver, J.C. (1995) Transdermal transport of DNA antisense oligonucleotides by electroporation. Biochem. Biophys. Res. Commun., 212, 286-92.
43. Zhang, L., Li, L., Hoffmann, G.A. and Hoffman, R.M. (1996). Depth-targeted efficient gene delivery and expression in the skin by pulsed electric fields: an approach to gene therapy of skin ageing and other diseases. Biochem. Biophys. Res. Commun., 220, 633-6.