Imaging of fluorescent molecule and small ion transport through human stratum corneum during high voltage pulsing: Localized transport regions are involved

Biophysical Chemistry

Volumn 58, Issue 1-2, 1996, Pages 185-204

  Pliquett, Uwe F ^a   Zewert, Thomas E ^a   Chen, Tani ^b   Langer, Robert ^b   Weaver, James C ^a  

^a HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Electroporation; Fluorescence microscopy; Transdermal transport

Indexed keywords

ARTICLE; CONTROLLED STUDY; ELECTROCHEMISTRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN TISSUE; ION TRANSPORT; NORMAL HUMAN; PRIORITY JOURNAL; SKIN; STRATUM CORNEUM;

EID: 0030071315     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/0301-4622(95)00098-4     Document Type: Article

References (22)

1. M.R. Prausnitz, V.G. Bose, R. Langer and J.C. Weaver, Transdermal drug delivery by electroporation, Proc. Int. Symp. Control. Rel. Bioact. Mater., 19 (1992) 232-233.
2. M.R. Prausnitz, V.G. Bose, R. Langer and J.C. Weaver, Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery, Proc. Natl. Acad. Sci. USA, 90 (1993) 10504-10508.
3. T.E. Zewert, U.F. Pliquett, R. Langer and J.C. Weaver, Transport of DNA antisense oligonucleotides across skin by electroporation, Biochem. Biophys. Res. Commun., 212 (1995) 286-292.
4. D. Bommannan, J. Tamada, L. Leung and R.O. Potts, Effect of electroporation on transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH) in vitro. Pharmacol. Res., 11 (1994) 1809-1814.
5. M.-R. Riviere, R.A. Rogers, D. Bommannan, J.A. Tamada and R.O. Potts, Pulsatile transdermal delivery of LHRH using electroporation: drug delivery and skin toxicology, J. Controlled Rel., (1995) in press.
6. U. Pliquett, R. Langer and J.C. Weaver, The change in the passive electrical properties of human stratum comeum due to electroporation, Biochim. Biophys. Acta, (1995) in press.
7. J.C. Weaver and A. Barnett, Progress towards a theoretical model for electroporation mechanism: membrane electrical behavior and molecular transport, in D.C. Chang, B.M. Chassy, J.A. Saunders and A.E. Sowers (Editors), Guide to Electroporation and Electrofusion, New York, Academic Press, 1992.
8. J.C. Weaver, Electroporation: a general phenomenon for manipulating cells and tissues, J. Cell. Biochem., 51 (1993) 426-435.
9. Y.A. Chizmadzhev, V. Zarnystin, J.C. Weaver and R.O. Potts, Mechanism of electroinduced ionic species transport through a multilamellar system, Biophys. J., 68 (1995) 749-765.
10. S. Grimnes, Pathways of ionic flow through human skin in vivo, Acta Derm. Venereol. (Stockholm), 64 (1984) 93-98.
11. E.R. Scott, H.S. White and J.B. Phipps, Direct imaging of ionic pathways in stratum corneum using scanning electrochemical microscopy, Solid State Ionics, 53-56 (1992) 176-183.
12. H.E. Boddé, I. van den Brink, H.K. Koerten and F.H.N. de Haan, Visualization of in vitro percutaneous penetration of mercuric chloride; transport through intercellular space versus cellular uptake through desmosomes, J. Controlled Release, 15 (1991) 227-236.
13. M.R. Prausnitz, R.H. Guy, R. Langer, J.C. Weaver and C. Cullander, Imaging regions of transport across human stratum corneum during high-voltage and low-voltage exposures, submitted for publication.
14. C.L. Gummer, The in vitro evaluation of transdermal delivery, in J. Hadgraft and R.H. Guy (Editor), Transdermal drug delivery: development issues and research initiatives, Marcel Dekker, New York, 1989.
15. R.M. Roberts, J.C. Gilbert, L.B. Rodewald and A.S. Wingrove, Modern Experimental Organic Chemistry, Saunders, Philadelphia, PA, 4th edn., 1985, p. 701.
16. U. Pliquett and J.C. Weaver, Transport of a charged molecule across the human epidermis due to electroporation, J. Controlled Rel., (1995) in press.
17. U. Pliquett, M.R. Prausnitz, Y.A. Chizmadzhev and J.C. Weaver, Measurement of rapid release kinetics for transdermal and other types of drug delivery, Pharmacol. Res., 4 (1995) 546-553.
18. U. Pliquett and J.C. Weaver, Electroporation of human skin: Simultaneous measurement of changes in the transport of two fluorescent molecules and in the passive electrical properties, Bioelectrochem. Bioenerget., (1995) in press.
19. E.R. Scott, A.I. Laplaza, H.S. White and J.B. Phipps, Transport of ionic species in skin: contribution of pores to the overall skin conductance, Pharmacol. Res., 10 (1993) 1699-1709.
20. K.T. Powell and J.C. Weaver, Transient aqueous pores in bilayer membranes: a statistical theory, Bioelectrochem. Bioenerg., 15 (1986) 211-227.
21. A. Barnett and J.C. Weaver, A unified, quantitative theory of reversible electrical breakdown and rupture, Bioelectrochem. Bioenerg., 25 (1991) 163-182.
22. S.A. Freeman, M.A. Wang and J.C. Weaver, Theory of electroporation of planar membranes: predictions of the aqueous area, change in capacitance and pore-pore separation, Biophys. J., 67 (1994) 42-56.