Transdermal delivery of fentanyl by electroporation II. Mechanisms involved in drug transport

Pharmaceutical Research

Volumn 13, Issue 9, 1996, Pages 1360-1366

  Vanbever, Rita ^a   De Morre, Nathalie ^a   Préat, Véronique ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

electroporation; fentanyl; transdermal drug delivery; transport mechanisms

Indexed keywords

FENTANYL;

ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; DRUG LABELING; DRUG TRANSPORT; IN VITRO STUDY; IONTOPHORESIS; ISOTOPE LABELING; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SKIN PENETRATION; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0029952896     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016073917125     Document Type: Article

References (21)

1. J. Hadgraft, and R. H Guy (Eds), Transdermal Drug Delivery: Developmental Issues and Research Initiatives, Marcel Dekker Inc (1989).
2. S. D. Roy and G. L. Flynn. Transdermal delivery of narcotic analgesics: pH, anatomical and subject influences on cutaneous permeability of fentanyl and sufentanil. Pharm. Res. 7:842-847 (1990).
3. J. R. Varvel, S. L. Shafer, S. S. Hwang, P. A. Coen, and D. R. Stanski. Absorption characteristics of transdermally administered fentanyl. Anethesiology 70:928-934 (1989).
4. M. R. Prausnitz, V. G. Bose, R. Langer, and J. C. Weaver. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. USA 90:10504-10508 (1993).
5. R. Vanbever, N. Lecouturier, and V. Préat. Transdermal delivery of metoprolol by electroporation. Pharm. Res. 11:1657-1662 (1994).
6. R. Vanbever and V. Préat. Factors affecting transdermal delivery of metoprolol by Electroporation. Bioelectrochem. Bioenerget. 38:223-228 (1995).
7. V. Préat and R. Vanbever. Transdermal drug delivery by electroporation, in Prediction of Percutaneous Penetration, vol 4 (in press).
8. U. Pliquett and J. C. Weaver. Electroporation of human skin: simultaneous measurement of changes in the transport of two fluorescent molecules and the passive electrical properties. Bioelectrochem. Bioenerget. 39:1-12 (1996).
9. R. Vanbever, E. Le Boulengé, and V. Préat. Transdermal delivery of fentanyl by electroporation I. Influence of Electrical factors. Pharm. Res. 13:559-565 (1996).
10. D. B. Bommannan, J. Tamada, L. Leung, and R. O. Potts. Effect of electroporation on transdermal iontophoretic delivery of Luteinizing Hormone (LHRH) in vitro. Pharm. Res. 11:1809-1814 (1994).
11. T. Zewert, U. Pliquett, R. Langer, and J. C. Weaver. Transdermal transport of DNA antisense oligonucleotides by electroporation. Biochem. Biophys. Acta 212 2:286-292 (1995).
12. M. R. Prausnitz, E. R. Edelman, J. A. Gimm, R. Langer, and J. C. Weaver. Transdermal delivery of heparin by skin electroporation. Biotechnology 13:1205-1209 (1995).
13. D. Chang, B. Chassy, J. Saunders, A. Sowers (Eds). Guide to Electroporation and Electrofusion, Academic Press Inc. (1992).
14. H. Schaefer and E. Lamaud. Standardization of experimental models. In Schott. B and Schaefer H. (Eds), Pharmacology of Skin, 1:77-80 (1987).
15. A. Jadoul, C. Hanchard, S. Thysman, V. Préat. Quantification and localization of fentanyl and TRH delivered by iontophoresis in the skin. Int J. Pharm. 120:221-228 (1995).
16. R. Guy (Ed) Iontophoresis Adv. Drug Delivery Rev. 9:119-317 (1992).
17. S. Thysman, V. Préat, and M. Roland. Factors affecting iontophoretic mobility of metoprolol. J. Pharm. Sci. 81:670-675 (1992).
18. S. Thysman, C. Tasset, and V. Préat. Transdermal iontophoresis of fentanyl: delivery and mechanistic analysis. Int. J. Pharm. 101:105-113 (1994).
19. M. B. Delgado-Charro, A. M. Rodriguez-Bayon, R. H. Guy. Iontophoresis of nafarelin: effects of current density and concentration on electrotransport in vitro. J. Controlled Release 35:35-40 (1995).
20. R. Vanbever, M.-A. Leroy, and V. Préat. Transdermal permeation of neutral molecules by electroporation (in preparation).
21. R. Vanbever, G. Langers, and V. Préat. Rapid onset of action of fentanyl delivered in vivo by skin electroporation (in preparation).