Skin electroporation: Rapid measurements of the transdermal voltage and flux of four fluorescent molecules show a transition to large fluxes near 50 V

Journal of Pharmaceutical Sciences

Volumn 87, Issue 11, 1998, Pages 1368-1374

  Chen, Tani ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCEIN; CASCADE BLUE; FLUORESCENT DYE; LUCIFER YELLOW; RHODAMINE; SULFORHODAMINE; UNCLASSIFIED DRUG;

BILAYER MEMBRANE; CADAVER; CONFERENCE PAPER; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG TRANSPORT; HUMAN; HUMAN TISSUE; SKIN PERMEABILITY; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0031766396     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980071k     Document Type: Conference Paper

References (30)

1. Prausnitz, M. R.; Böse, V. G.; Langer, R.; Weaver, J. C. Electroporation of Mammalian Skin: A Mechanism to Enhance Transdermal Drug Delivery. Proc. Natl. Acad. Sei. U.S.A. 1993,90, 10504-10508.
2. Bommannan, D.; Tamada, J.; Leung, L.; Potts, R. O. Effect of Electroporation on Transdermal lontophoretic Delivery of Luteinizing Hormone Releasing Hormone (LHRH) in Vitro. Pharm. Res. 1994, 11, 1809-1814.
3. Vanbever, R.; Lecouturier, N.; Préat, V. Transdermal Delivery of Metoprolol by Electroporation. Pharm. Res. 1994, 11, 1657-1662.
4. Prausnitz, M. R.; Edelman, E. R.; Gimm, J. A.; Langer, R.; Weaver, J. C. Transdermal Delivery of Heparin by Skin Electroporation. Bio I Technology 1995, 13, 1205-1209.
5. Riviere, J. E.; Monteiro-Riviere, N. A.; Rogers, R. A.; Bommannan, D. Tamada, J. A.; Potts, R. 0. Pulsatile Transdermal Delivery of LHRH Using Electroporation: Drug Delivery and Skin Toxicology. J. Controlled Release 1995, 36, 229233.
6. Zewert, T. E.; Pliquett, U. F.; Langer, R.; Weaver, J. C. Transdermal Transport of DNA Antisense Oligonucleotides by Electroporation. Biochem. Biophys. Res. Commun. 1995, 212, 286-292.
7. Pliquett, U.; Weaver, J. C. Electroporation of Human Skin: Simultaneous Measurement of Changes in the Transport of Two Fluorescent Molecules and in the Passive Electrical Properties. Bioelectrochem. Bioenerget. 1996, 39, 1-12.
8. Prausnitz, M. R.; Gimm, J. A.; Guy, R. H.; Langer, R.; Weaver, J. C.; Cullander, C. Imaging of Transport Pathways across Human Stratum Corneum during High-Voltage and Low-Voltage Electrical Exposures. J. Pharm. Sei. 1996, 85, 1363-1370.
9. Vanbever, R.; Le Boulengé, E.; Préat, V. Transdermal Delivery of Fentanyl by Electroporation I. Influence of Electrical Factors. Pharm. Res. 1996, 13, 559-565.
10. Jadoul, A.; Préat, V. Electrically-Enhanced Transdermal Delivery of Domperidone. Int. J. Pharm. 1997, 154, 229234.
11. Vanbever, R.; Prausnitz, M. R.; Preat, V. Macromolecules as Novel Transdermal Transport Enhancers for Skin Electroporation. Pharm. Res. 1997, 14, 638-644.
12. Weaver, J. C.; Vanbever, R.; Vaughan, T. E.; Prausnitz, M. R. Heparin Alters Transdermal Transport Associated with Electroporation. Biochem. Biophys. Res. Commun. 1997,234, 637-640.
13. Pliquett, U.; Langer, R.; Weaver, J. C. Changes in the Passive Electrical Properties of Human Stratum Corneum Due to Electroporation. Biochim. Biophys. Acta 1995, 1239, HI121.
14. Vanbever, R.; Preat, V. Factors Affecting Transdermal Delivery of Metoprolol by Electroporation. Bioelectrochem. Bioenerget. 1995, 38, 223-228.
15. Prausnitz, M. R.; Lee, C. S.; Liu, C. H.; Pang, J. C.; Singh, T.-P.; Langer, R.; Weaver, J. C. Transdermal Transport Efficiency During Skin Electroporation and Iontophoresis. J. Controlled Release 1996, 38, 205-217.
16. Vanbever, R.; De Morre, N.; Préat, V. Transdermal Delivery of Fentanyl by Electroporation. II. Mechanisms Involved in Drug Transport. Pharm. Res. 1996, 13, 1359-1365.
17. Gallo, S. A; Oseroff, A. R.; Johnson, P. G.; Hui, S. W. Characterization of Electric-Pulse-Induced Permeabilization of Porcine Skin Using Surface Electrodes. Biophys. J. 1997, 72, 2805-2811.
18. Vanbever, R.; Pliquett, U. F.; Préat, V.; Weaver, J. C. Transdermal Transport and Changes in Skin Electrical Properties due to Short and Long High Voltage Pulses. Unpublished results.
19. Prausnitz, M. R.; Seddick, D. S.; Kon, A. A.; Böse, V. G.; Frankenburg, S.; Klaus, S. N.; Langer, R.; Weaver, J. C. Methods For in Vivo Tissue Electroporation Using Surface Electrodes. Drug Deliu. 1993, 1, 125-131.
20. Chen, T.; Langer, R.; Weaver, J. C. Skin Electroporation Causes Molecular Transport Across the Stratum Corneum Through Localized Transport Regions. J. Invest. DermatoL, in press.
21. Pliquett, U.; Prausnitz, M. R.; Chizmadzhev, Y. A.; Weaver, J. C. Measurement of Rapid Release Kinetics for Drug Delivery. Pharm. Res. 1995,12, 549-555 (Errata in Pharm. Res. 1995, 12, 1244).
22. Pliquett, U.; Zewart, T. E.; Chen, T.; Langer, R.; Weaver, J. C. Imaging of Fluorescent Molecule and Small Ion Transport Through Human Stratum Corneum During High Voltage Pulsing: Localized Transport Regions are Involved. Biophys. Chem. 1996, 58, 185-204.
23. Pliquett, U.; Weaver, J. C. Transport of a charged molecule across the human epidermis due to electroporation. J. Controlled Release 1996, 38, 1-10.
24. Chizmadzhev, Y. A.; Zarnytsin, V. G.; Weaver, J. C.; Potts, R. O. Mechanism of electroinduced ionic species transport through a multilamellar lipid system. Biophys. J. 1995, 68, 749-765.
25. Chizmadzhev, Y.; Indenbom, A. V.; Kuzmin, P. I.; Galichenko, S. V.; Weaver, J. C.; Potts, R. O. Electrical Properties of Skin at Moderate Voltages. Biophys. J. 1998, 74, 843-856.
26. Prausnitz, M. R.; Pliquett, U.; Langer, R.; Weaver, J. C. Rapid Temporal Control of Transdermal Drug Delivery by Electroporation. Pharm. Res. 1994, 11, 1834-1837.
27. Kost, J.; Pliquett, U.; Mitragotri, S.; Yamamoto, A.; Langer, R.; Weaver, J. Synergistic Effect of Electric Field and Ultrasound on Transdermal Transport. Pharm. Res. 1996, 13, 633-638.
28. Gummer, C. L. The in Vitro Evaluation of Transdermal Delivery. In Transdermal Drug Delivery: Developmental Issues and Research Inititatives; Hadgraft, J., Guy, R. H., Eds.; Marcel Dekker: New York, 1989; pp 176-186.
29. Friend, D. R. In Vitro Skin Permeation Techniques. J. Controlled Release 1996, 18, 235-248.
30. Fogler, H. S. Elements of Chemical Reaction Engineering. Prentice Hall: Englewood Cliffs, NJ, 1992.