A domain at the C-terminus of PS1 is required for presenilinase and γ-secretase activities

Journal of Neurochemistry

Volumn 92, Issue 5, 2005, Pages 1158-1169

  Brunkan, A L ^a   Martinez, M ^a   Wang, J ^a   Walker, E S ^a   Goate, A M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

secretase; Alzheimer's disease; Nicastrin; Presenilin; Presenilinase

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ENZYME; GAMMA SECRETASE; MUTANT PROTEIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1; PRESENILINASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN TRANSPORT; TRANSGENE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; CALNEXIN; CELL LINE; COATOMER PROTEIN; CYCLOHEXIMIDE; ENDOPEPTIDASES; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MUTATION, MISSENSE; OLIGOPEPTIDES; PROTEIN STRUCTURE, TERTIARY; PROTEIN SYNTHESIS INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; QB-SNARE PROTEINS; SUBCELLULAR FRACTIONS; TIME FACTORS; TRANSFECTION;

EID: 14844304298     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02945.x     Document Type: Article

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