메뉴 건너뛰기




Volumn 37, Issue 5 SPEC. ISS., 2005, Pages 1117-1129

Insulin in aging and cancer: Antidiabetic drug diabenol as geroprotector and anticarcinogen

Author keywords

1,2 Dimethylhydrazine; Aging; Antidiabetic drugs; Carcinogenesis; Colon cancer; Diabenol; Mammary carcinoma

Indexed keywords

1,2 DIMETHYLHYDRAZINE; 9 BETA DIETHYLAMINOETHYL 2,3 DIHYDROIMIDAZO[1,2 A]BENZIMIDAZOLE; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; DIABENOL; UNCLASSIFIED DRUG;

EID: 14644423985     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2004.08.002     Document Type: Article
Times cited : (23)

References (68)
  • 1
    • 0019136073 scopus 로고
    • The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats
    • V.A. Alexandrov, V.N. Anisimov, N.M. Belous, I.A. Vasilyeva, and V.B. Mazon The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats Carcinogenesis 1 1980 975 978
    • (1980) Carcinogenesis , vol.1 , pp. 975-978
    • Alexandrov, V.A.1    Anisimov, V.N.2    Belous, N.M.3    Vasilyeva, I.A.4    Mazon, V.B.5
  • 2
    • 0019227034 scopus 로고
    • Effect of buformin and diphenylhydantoin on life span, estrus function and spontaneous tumor incidence in female rats
    • V.N. Anisimov Effect of buformin and diphenylhydantoin on life span, estrus function and spontaneous tumor incidence in female rats Voprosy Onkologii 26 6 1980 42 48
    • (1980) Voprosy Onkologii , vol.26 , Issue.6 , pp. 42-48
    • Anisimov, V.N.1
  • 3
    • 0142186132 scopus 로고    scopus 로고
    • Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention
    • V.N. Anisimov Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention Experimental Gerontology 38 2003 1041 1049
    • (2003) Experimental Gerontology , vol.38 , pp. 1041-1049
    • Anisimov, V.N.1
  • 4
    • 0142200245 scopus 로고
    • Inhibitory effect of phenformin on the development of mammary tumors induced by N-nitrosomethylurea in rats
    • V.N. Anisimov, N.M. Belous, I.A. Vasilyeva, and V.M. Dilman Inhibitory effect of phenformin on the development of mammary tumors induced by N-nitrosomethylurea in rats Experimental Onkology 2 3 1980 40 43
    • (1980) Experimental Onkology , vol.2 , Issue.3 , pp. 40-43
    • Anisimov, V.N.1    Belous, N.M.2    Vasilyeva, I.A.3    Dilman, V.M.4
  • 5
    • 0019164406 scopus 로고
    • Inhibition of blastomogenic effect of 7,12-dimethylbenz(a)anthracene in female rats by buformin, dipheninhydantoin, polypeptide pineal extract and L-DOPA
    • V.N. Anisimov, M.N. Ostroumova, and V.M. Dilman Inhibition of blastomogenic effect of 7,12-dimethylbenz(a)anthracene in female rats by buformin, dipheninhydantoin, polypeptide pineal extract and L-DOPA Bulletin of Experimental Biology and Medicine 89 1980 723 725
    • (1980) Bulletin of Experimental Biology and Medicine , vol.89 , pp. 723-725
    • Anisimov, V.N.1    Ostroumova, M.N.2    Dilman, V.M.3
  • 6
    • 0019230722 scopus 로고
    • Effect of phenformin on the blastomogenic action of 1,2-dimethylhydrazine in rats
    • V.N. Anisimov, K.M. Pozharisski, and V.M. Dilman Effect of phenformin on the blastomogenic action of 1,2-dimethylhydrazine in rats Voprosy Onkologii 26 8 1980 54 58
    • (1980) Voprosy Onkologii , vol.26 , Issue.8 , pp. 54-58
    • Anisimov, V.N.1    Pozharisski, K.M.2    Dilman, V.M.3
  • 7
    • 0142169315 scopus 로고
    • Inhibition by phenformin of the radiation carcinogenesis in female rats
    • V.N. Anisimov, N.M. Belous, and E.A. Prokudina Inhibition by phenformin of the radiation carcinogenesis in female rats Experimental Onkology 4 6 1982 26 29
    • (1982) Experimental Onkology , vol.4 , Issue.6 , pp. 26-29
    • Anisimov, V.N.1    Belous, N.M.2    Prokudina, E.A.3
  • 9
    • 0036722946 scopus 로고    scopus 로고
    • Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    • V.N. Anisimov, V.Kh. Khavinson, and I.G. Popovich Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice International Journal of Cancer 101 2002 7 10
    • (2002) International Journal of Cancer , vol.101 , pp. 7-10
    • Anisimov, V.N.1    Khavinson, V.Kh.2    Popovich, I.G.3
  • 10
    • 0344394514 scopus 로고    scopus 로고
    • Insulin and longevity: Antidiabetic biguanides as geroprotectors
    • V.N. Anisimov, A.V. Semenchenko, and A.I. Yashin Insulin and longevity: antidiabetic biguanides as geroprotectors Biogerontology 4 2003 297 307
    • (2003) Biogerontology , vol.4 , pp. 297-307
    • Anisimov, V.N.1    Semenchenko, A.V.2    Yashin, A.I.3
  • 11
    • 0036765735 scopus 로고    scopus 로고
    • Synthesis and pharmacological activity of 1- and 10-N-substituted 1(10),2,3,4,-tetrahydropyrimido[1,2-a]benzimidazoles
    • V.A. Anisimova, V.V. Osipova, and A.A. Spasov Synthesis and pharmacological activity of 1- and 10-N-substituted 1(10),2,3,4,- tetrahydropyrimido[1,2-a]benzimidazoles Chemico-Pharmaceutical Journal 36 9 2002 11 16
    • (2002) Chemico-Pharmaceutical Journal , vol.36 , Issue.9 , pp. 11-16
    • Anisimova, V.A.1    Osipova, V.V.2    Spasov, A.A.3
  • 13
    • 0037231580 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF-1) and aging: Controverses and new insights
    • A. Bartke, V. Chandrashekar, and F. Dominici Insulin-like growth factor 1 (IGF-1) and aging: controverses and new insights Biogerontology 4 2003 1 8
    • (2003) Biogerontology , vol.4 , pp. 1-8
    • Bartke, A.1    Chandrashekar, V.2    Dominici, F.3
  • 14
    • 0022101961 scopus 로고
    • Influence of anticarcinogenic agents on the transplacental carcinogenic effect of N-nitroso-N-ethylurea
    • V.G. Bespalov, and V.A. Alexandrov Influence of anticarcinogenic agents on the transplacental carcinogenic effect of N-nitroso-N-ethylurea Bulletin of Experimental Biology and Medicine 100 1985 73 76
    • (1985) Bulletin of Experimental Biology and Medicine , vol.100 , pp. 73-76
    • Bespalov, V.G.1    Alexandrov, V.A.2
  • 15
    • 0024385485 scopus 로고
    • Spontaneous tumors in NMRI mice from carcinogenicity studies
    • E. Bomhard, and U. Mohr Spontaneous tumors in NMRI mice from carcinogenicity studies Experimental Pathology 36 1989 129 145
    • (1989) Experimental Pathology , vol.36 , pp. 129-145
    • Bomhard, E.1    Mohr, U.2
  • 16
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • A. Brunet, L.B. Sweeney, and F. Sturgill Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2004 2011 2015
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, F.3
  • 17
    • 0242459925 scopus 로고    scopus 로고
    • Effects of phenformin on the proliferation of human tumor cell lines
    • F. Caraci, M. Chisari, and G. Frasca Effects of phenformin on the proliferation of human tumor cell lines Life Science 74 2003 643 650
    • (2003) Life Science , vol.74 , pp. 643-650
    • Caraci, F.1    Chisari, M.2    Frasca, G.3
  • 18
    • 0037112250 scopus 로고    scopus 로고
    • Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling
    • T. Chiba, H. Yamaza, Y. Higami, and I. Shimokawa Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling Microscopy Research and Technique 59 2002 317 324
    • (2002) Microscopy Research and Technique , vol.59 , pp. 317-324
    • Chiba, T.1    Yamaza, H.2    Higami, Y.3    Shimokawa, I.4
  • 19
    • 3142740860 scopus 로고    scopus 로고
    • Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    • Cohen, H. Y., Miller, C., Bitterman, K. J., et al. (2004). Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science, http://www.sciencexpress.org/17June/Page1/10.1126/Science.1099196.
    • (2004) Science
    • Cohen, H.Y.1    Miller, C.2    Bitterman, K.J.3
  • 22
    • 0015220921 scopus 로고
    • Age-associated elevation of hypothalamic threshold to feedback control and its role in development, aging and disease
    • V.M. Dilman Age-associated elevation of hypothalamic threshold to feedback control and its role in development, aging and disease Lancet 1 1971 1211 1219
    • (1971) Lancet , vol.1 , pp. 1211-1219
    • Dilman, V.M.1
  • 23
    • 0018077244 scopus 로고
    • Ageing, metabolic immunodepression and carcinogenesis
    • V.M. Dilman Ageing, metabolic immunodepression and carcinogenesis Mechanisms of Ageing and Development 8 1978 153 173
    • (1978) Mechanisms of Ageing and Development , vol.8 , pp. 153-173
    • Dilman, V.M.1
  • 25
    • 0018895934 scopus 로고
    • Effect of treatment with phenofromin, dyphenylhydantoin or L-DOPA on life span and tumor incidence in C3H/Sn mice
    • V.M. Dilman, and V.N. Anisimov Effect of treatment with phenofromin, dyphenylhydantoin or L-DOPA on life span and tumor incidence in C3H/Sn mice Gerontology 26 1980 241 245
    • (1980) Gerontology , vol.26 , pp. 241-245
    • Dilman, V.M.1    Anisimov, V.N.2
  • 28
  • 32
    • 0003489142 scopus 로고
    • Maple Valley: Aptech Systems Inc.
    • Gauss system and graphic manual. (1994). Maple Valley: Aptech Systems Inc.
    • (1994) Gauss System and Graphic Manual
  • 35
    • 0002158748 scopus 로고    scopus 로고
    • Human implications of caloric restriction's effect on laboratory animals: An overview of opportunities for research
    • Hadley, E. C., Dutta, C., Finkelstein, J., et al. (2001). Human implications of caloric restriction's effect on laboratory animals: an overview of opportunities for research. Journal of Gerontology Ser. A, 56A(Special issue I), 5-6.
    • (2001) Journal of Gerontology Ser. A , vol.56 A , Issue.1 SPEC. ISSUE , pp. 5-6
    • Hadley, E.C.1    Dutta, C.2    Finkelstein, J.3
  • 36
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sitruins extend Saccharomyces cerevisiae lifespan
    • K.T. Howitz, K.J. Bitterman, and H.Y. Cohen Small molecule activators of sitruins extend Saccharomyces cerevisiae lifespan Nature 425 2003 191 196
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3
  • 37
  • 38
    • 0027939533 scopus 로고
    • Comparative tolerability profilesof oral antidiabeticagents
    • A.J. Krentz, R.E. Ferner, and C.J. Balley Comparative tolerability profilesof oral antidiabeticagents Drug Safety 11 1994 223 241
    • (1994) Drug Safety , vol.11 , pp. 223-241
    • Krentz, A.J.1    Ferner, R.E.2    Balley, C.J.3
  • 39
    • 14644431396 scopus 로고    scopus 로고
    • Review: Metformin does not increase risk for lactic acidosis or increase lactate levels in type 2 diabetes
    • Kruse, J. A. (2004). Review: metformin does not increase risk for lactic acidosis or increase lactate levels in type 2 diabetes. ACP Journal Club, 141, 7.
    • (2004) ACP Journal Club , vol.141 , pp. 7
    • Kruse, J.A.1
  • 40
    • 0037470488 scopus 로고    scopus 로고
    • Evolutionary medicine: From dwarf model systems to healthy centenarians
    • V.D. Longo, and C.E. Finch Evolutionary medicine: from dwarf model systems to healthy centenarians Science 299 2003 1342 1346
    • (2003) Science , vol.299 , pp. 1342-1346
    • Longo, V.D.1    Finch, C.E.2
  • 41
    • 0034033586 scopus 로고    scopus 로고
    • Caloric restriction and ageing: An update
    • E.J. Masoro Caloric restriction and ageing: an update Experimental Gerontology 35 2000 299 305
    • (2000) Experimental Gerontology , vol.35 , pp. 299-305
    • Masoro, E.J.1
  • 42
    • 0141611988 scopus 로고    scopus 로고
    • Subfield history: Caloric restriction, slowing aging, and extending life
    • 2003. ns2 (26 February 2003).
    • Masoro, E.J. (2003). Subfield history: caloric restriction, slowing aging, and extending life. Science's SAGE KE, 2003. ns2 (26 February 2003). http://sageke.sciencemag.org/cgi/content/full/sageke;2003/8/re2.
    • (2003) Science's SAGE KE
    • Masoro, E.J.1
  • 43
    • 0035200950 scopus 로고    scopus 로고
    • Progress in the development of caloric restriction mimetic dietary supplements
    • M.P. Mattson, W. Duan, and J. Lee Progress in the development of caloric restriction mimetic dietary supplements Journal of Anti-Ageing Medicines 4 2001 225 232
    • (2001) Journal of Anti-Ageing Medicines , vol.4 , pp. 225-232
    • Mattson, M.P.1    Duan, W.2    Lee, J.3
  • 44
    • 3242777031 scopus 로고    scopus 로고
    • Chron activation of AMP-activated kinase as a strategyforslowing aging
    • M.F. McCarty Chron activation of AMP-activated kinase as a strategyforslowing aging Medical Hypotheses 63 2004 334 339
    • (2004) Medical Hypotheses , vol.63 , pp. 334-339
    • McCarty, M.F.1
  • 45
    • 0001390787 scopus 로고
    • Tests for differences in tumor incidence based on animal carcinogenesis experiments
    • B. McKnight, and J. Crowley Tests for differences in tumor incidence based on animal carcinogenesis experiments Journal of American Statistical Association 80 1984 639 648
    • (1984) Journal of American Statistical Association , vol.80 , pp. 639-648
    • McKnight, B.1    Crowley, J.2
  • 46
    • 14644413298 scopus 로고    scopus 로고
    • Synthesis and antioxidant activity N.N-substituted 3-amino-1H-1,2- diasaphenalenes
    • V.V. Mezheritski, A.L. Pikus, and A.A. Spasov Synthesis and antioxidant activity N.N-substituted 3-amino-1H-1,2-diasaphenalenes Chemical-Pharmaceutical Journal 1 1998 15 16
    • (1998) Chemical-Pharmaceutical Journal , vol.1 , pp. 15-16
    • Mezheritski, V.V.1    Pikus, A.L.2    Spasov, A.A.3
  • 47
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • M.C. Motta, N. Divecha, and M. Lemieux Mammalian SIRT1 represses forkhead transcription factors Cell 116 2004 551 563
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1    Divecha, N.2    Lemieux, M.3
  • 48
    • 0032904778 scopus 로고    scopus 로고
    • Metformin and fatty acids
    • S. Muntoni Metformin and fatty acids Diabetes Care 22 1999 179 180
    • (1999) Diabetes Care , vol.22 , pp. 179-180
    • Muntoni, S.1
  • 49
    • 0036153118 scopus 로고    scopus 로고
    • Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome
    • J.E. Nestler, D. Stovall, N. Akhther, M.J. Iorno, and D.J. Jakubowicz Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome Fertility and Sterility 77 2002 209 215
    • (2002) Fertility and Sterility , vol.77 , pp. 209-215
    • Nestler, J.E.1    Stovall, D.2    Akhther, N.3    Iorno, M.J.4    Jakubowicz, D.J.5
  • 51
    • 3042681042 scopus 로고    scopus 로고
    • Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
    • F. Picard, M. Kurtev, and N. Chung Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ Nature 429 2004 771 776
    • (2004) Nature , vol.429 , pp. 771-776
    • Picard, F.1    Kurtev, M.2    Chung, N.3
  • 59
    • 0034834441 scopus 로고    scopus 로고
    • Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL/6 mice
    • D. Sun, A.R. Muthukumar, R.A. Lawrence, and G. Fernandes Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL/6 mice Clinical and Diagnostic Laboratory Immunology 8 2001 1003 1011
    • (2001) Clinical and Diagnostic Laboratory Immunology , vol.8 , pp. 1003-1011
    • Sun, D.1    Muthukumar, A.R.2    Lawrence, R.A.3    Fernandes, G.4
  • 60
    • 0016759979 scopus 로고
    • Tests for trend in life table analysis
    • R.E. Taron Tests for trend in life table analysis Biometrika 62 1975 679 682
    • (1975) Biometrika , vol.62 , pp. 679-682
    • Taron, R.E.1
  • 61
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • M. Tatar, A. Bartke, and A. Antebi The endocrine regulation of aging by insulin-like signals Science 299 2003 1346 1351
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 62
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extendslifespanin Caenorhabditis elgans
    • H.A. Tissenbaum, and L. Guarente Increased dosage of a sir-2 gene extendslifespanin Caenorhabditis elgans Nature 410 2001 227 230
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 64
    • 0019376378 scopus 로고
    • Effect of phenformin, L-DOPA and para-chlorophenylalanine on the immunological reactivity and chemical carcinogenesis in BALB/c mice
    • V.B. Vinnitski, and V.A. Iakimenko Effect of phenformin, L-DOPA and para-chlorophenylalanine on the immunological reactivity and chemical carcinogenesis in BALB/c mice Voprosy Onkologii 27 6 1981 45 50
    • (1981) Voprosy Onkologii , vol.27 , Issue.6 , pp. 45-50
    • Vinnitski, V.B.1    Iakimenko, V.A.2
  • 67
    • 0032942240 scopus 로고    scopus 로고
    • Enhanced potential for oxidative stress in hyperinsulinemic rats: Imbalance between hepatic peroxisomal hydrogen peroxide production and decomposition due to hyperinsulinemia
    • L. Xu, and M.Z. Bard Enhanced potential for oxidative stress in hyperinsulinemic rats: imbalance between hepatic peroxisomal hydrogen peroxide production and decomposition due to hyperinsulinemia Hormone and Metabolic Research 31 1999 278 282
    • (1999) Hormone and Metabolic Research , vol.31 , pp. 278-282
    • Xu, L.1    Bard, M.Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.