Synthesis and pharmacological activity of 1-N-and 10-n-substituted 1(10),2,3,4-tetrahydropyrimido-[1,2-a]benzimidazoles

Pharmaceutical Chemistry Journal

Volumn 36, Issue 9, 2002, Pages 468-473

  Anisimova, V A ^a   Osipova, M M ^a   Spasov, A A ^b   Turchaeva, A F ^b   Dudchenko, G P ^b   Larionov, N P ^b   Kovalev, S G ^b  

^a SOUTHERN FEDERAL UNIVERSITY   (Russian Federation)

^b VOLGOGRAD STATE MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

1 (10),2,3,4 TETRAHYDROPYRIMIDO[1,2 A]BENZIMIDAZOLE DERIVATIVE; 1,2,3,4 TETRAHYDROPYRIMIDO[1,2 A]BENZIMIDAZOLE SALT DERIVATIVE; 10 DIALKYLAMINOETHYL 2,3,4,10 TETRAHYDROPYRIMIDO[1,2 A]BENZIMIDAZOLE SALT DERIVATIVE; 2 (2 DIALKYLAMINOETHYL)BENZIMIDAZOLE DERIVATIVE; 2 (3 CHLOROPROPYLAMINO)BENZIMIDAZOLE DERIVATIVE; 2 (3 HYDROXYPROPYLAMINO)BENZIMIDAZOLE DERIVATIVE; 2,3,4,10 TETRAHYDROPYRIMIDO[1,2 A]BENZIMIDAZOLE SALT DERIVATIVE; ACETYLSALICYLIC ACID; BENDAZOL; BENZIMIDAZOLE DERIVATIVE; CHLORPROPAMIDE; CIMETIDINE; CINNARIZINE; DILTIAZEM; GLUCOSE; HYDRALAZINE; PAPAVERINE; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; HYPOTENSION; MUSCLE CONTRACTION; NONHUMAN; RAT; STOMACH ACID; THROMBOCYTE AGGREGATION; TOXICITY TESTING;

EID: 0036765735     PISSN: 0091150X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021888520874     Document Type: Article

References (24)

1. A. M. Simonov, G. V. Kovalev, V. A. Anisimova, et al., USSR Inventor's Certificate no. 566,588; No. 28, 13 (1977).
2. V. A. Anisimova, M. V. Levchenko, G. V. Kovalev, et al., Khim.-Farm. Zh., 21(3), 313 - 319 (1987).
3. V. A. Anisimova, A. A. Spasov, I. A. Bocharova, et al., Khim.-Farm. Zh., 30(1), 22 - 25 (1996).
4. V. A. Anisimova, M. V. Levchenko, T. B. Korochina, et al., Fr. Patent 2691462 (1995); Bull., 95 / 23; EP 0571253.
5. P. M. Kochergin, Khim. Geterotsikl. Soedin., No. 1, 137 - 140 (1967).
6. V. A. Anisimova, M. V. Levchenko, Yu. V. Koshchienko, and A. F. Pozharskii, USSR Inventor's Certificate No. 952,847; Byull. Izobret., No. 31, 126 (1982).
7. A. V. El'tsov and K. M. Krivozheiko, Zh. Org. Khim., 2, 189 (1966).
8. A. F. Pozharskii, V. A. Anisimova, and E. B. Tsupak, A Practical Guide in the Chemistry of Heterocycles [in Russian], Izdat. Rostov. Univ., Rostov-on-Don (1988).
9. A. M. Simonov and V. N. Komissarov, Khim. Geterotsikl. Soedin., No. 6, 826 - 828 (1976).
10. S. M. Deshpande and K. Nain, Bull. Chem. Soc. Jpn., 40(4), 998 (1967),
11. E. Hoggarth, J. Chem. Soc., 3311 (1949).
12. Ya. I. Khodzhai, G. V. Obolentseva, and A. P. Prokopenko, Farmakol. Toksikol., 29, 156 - 160 (1966).
13. G. V. R. Born, Nature, 194, 927 - 929 (1962).
14. G. Holland, D. Jaeger, R. Wagner, et al., J. Med. Pharm. Chem., 3, 99 (1961).
15. Y. Shay, S. A. Komarov, S. S. Fels, et al., Gastroenterology, 5, 43 - 61 (1945).
16. M. L. Anson, J. Gen. Phisiol., 22, 79 - 89 (1938).
17. K. Golenhofen, N. Hermstein, and E. Lammel, Microvasc. Res., 5, 73 - 80 (1973).
18. V. Chaffman and R. N. Brogden, Drugs, 29(5), 387 - 454 (1985).
19. R. Gopalokrishna and W. B. Anderson, Biochem. Biophis. Res. Commun., 104, 830 - 836 (1982).
20. W. J. Thompson, W. L. Terasaki, P. M. Epstein, and S. J. Strada, Adv. Cyclic Nucleotide Res., 10, 69 (1979).
21. R. l. Kinkaid, V. C. Manganiello, and M. Voughan, J. Biol. Chem., 256, 11345 - 11350 (1981).
22. A. I. Venchikov and V. A. Venchikov, The Main Techniques for Statistical Processing of the Results of Observations in Physiology [in Russian], Meditsina, Moscow (1974), p. 152.
23. G. V. Kovalev, A. A. Spasov, and P. A. Bakumov, Khim.-Farm. Zh., 24(4), 85 - 87 (1990).
24. A. A. Spasov, G. A. Kovalev, and P. A. Bakumov, Farmakol. Toksikol., 53(4), 30 - 33 (1990).