Glucose tolerance, glucose utilization and insulin secretion in ageing

Novartis Foundation Symposium

Volumn 242, Issue , 2002, Pages 222-246

  Elahi, Dariush ^a   Muller, Denis C ^b   Egan, Josephine M ^b   Andres, Reubin ^b   Veldhuis, Johannes ^c   Meneilly, Graydon S ^d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 (7 36)AMIDE; GLUCAGON-LIKE PEPTIDE 1 (7-36)AMIDE; GLUCOSE; INSULIN; PEPTIDE FRAGMENT;

AGING; GLUCOSE TOLERANCE TEST; HUMAN; LIVER; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; REVIEW;

AGING; DIABETES MELLITUS, TYPE 2; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDES; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; ISLETS OF LANGERHANS; LIVER; PEPTIDE FRAGMENTS;

EID: 0036357078     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (64)

1. Andersen DK, Elahi D, Brown JC, Tobin JD, Andres R 1978 Oral glucose augmentation of insulin secretion. Interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels. J Clin Invest 62:152-161
2. Andres R 1971 Aging and diabetes. Med Clin North Am 55:835-846
3. Barbieri M, Rizzo MR, Manzella D, Paolisso G 2001 Age-related insulin resistance: is it and obligatory finding? The lesson from healthy centenarians. Diabetes Metab Res Rev 17:19-26
4. Bennett PH, Rushfroth NB, Miller M, Lecompte PM 1976 Epidemiologic studies of diabetes in the Pima Indians. Recent Prog Horm Res 32:333-376
5. Broughton DL, Taylor R 1991 Review: deterioration of glucose tolerance with age: the role of insulin resistance. Age Ageing 20:221-225
6. Chen M, Bergman R, Pacini G, Porte DJ 1985 Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab 60:13-20
7. Coon PJ, Bleecker ER, Drinkwater DT, Meyers DA, Goldberg AD 1989 Effects of body composition and exercise capacity on glucose tolerance, insulin, and lipoprotein lipids in healthy older men: a cross-sectional and longitudinal intervention study. Metabolism 38:1201-1209
8. Davidson MB 1979 The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism 28:688-705
9. DeFronzo RA 1979 Glucose intolerance and aging: evidence for tissue insensitivity to insulin. Diabetes 28:1095-1101
10. DeFronzo RA 1981 Glucose intolerance and aging. Diabetes Care 4:493-501
11. DeFronzo RA 1988 Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37:667-687
12. DeFronzo R, Ferrannini E 1991 Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194
13. DeFronzo R, Tobin JD, Andres R 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
14. DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J 1983 Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32:35-45
15. Dowse G, Spark R, Mavo B et al 1994 Extraordinary prevalence of non-insulin-dependent diabetes mellitus and bimodal plasma glucose distribution in the Wanigela people of Papua New Guinea. Med J Aust 160:767-774
16. Egan J, Clocquet A, Elahi D 1999 Insulinotropic effect of exendin-4 in humans. Diabetologia 42:148A
17. Elahi D 1996 In praise of the hyperglycemic clamp. A method of assessment of beta-cell sensitivity and insulin resistance. Diabetes Care 19:278-286
18. Elahi D, Muller DC 2000 Carbohydrate metabolism in the elderly. Eur J Clin Nutr 54: S112-S120
19. Elahi D, Andersen DC, Brown J et al 1979 Pancreatic alpha- and beta-cell responses to GIP infusion in normal man. Am J Physiol 237:E185-E191
20. Elahi D, Andersen DC, Muller DC, Tobin JD, Brown JC, Andres R 1984 The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity and non-insulin-dependent diabetes mellitus. Diabetes 33:950-957
21. Elahi D, Muller DC, McAloon-Dyke M, Tobin JD, Andres R 1993 The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus. Exp Gerontol 28:393-409
22. Elahi D, McAloon-Dyke M, Fukagawa N et al 1994 The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regul Pept 51:63-74
23. Engdahl J, Veldhuis J, Farrell P 1977 Altered pulsatile insulin secretion associated with endurance training. J Appl Physiol 79:1977-1985
24. Evans W, Farrell P 2001 The aging pancreas: effects of aging on insulin secretion action. In: Jefferson LS, Cherrington AD (eds) Handbook of Physiology. Section 7: The endocrine system. Vol 2: The endocrine pancreas and regulation of metabolism. Oxford University Press, Oxford, p 969-998
25. Ferrannini E, Vichi S, Beck-Nielsen H, Laakso M, Paolisso G, Smith U 1996 Insulin action and age. European group for the study of insulin resistance (EGIR). Diabetes 45:947-953
26. Fink RI, Kolterman OG, Griffin J, Olefsky JM 1983 Mechanisms of insulin resistance in aging. J Clin Invest 71:1523-1535
27. Harris M, Flegal K, Cowie C et al 1998 Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults. The third national health and nutrition examination survey, 1988-1994. Diabetes Care 21:518-524
28. Jackson RA, Blix PM, Matthews JA et al 1982 Influence of ageing on glucose homeostasis. J Clin Endocrinol Metab 55:840-848
29. Kaplan NM 1989 The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 149:1514-1520
30. Loo SG, Dowse GK, Finch C, Zimmer P 1993 Bimodality analysis of frequency distributions of 2-hour plasma glucose concentrations in the urban Micronesian population of Kiribati. J Diabetes Complicat 7:73-80
31. Maneatis T, Condie R, Reaven G 1982 Effect of age on plasma glucose and insulin responses to a test mixed meal. J Am Geriatr Soc 30:178-182
32. Meneilly G, Minaker K, Elahi D, Rowe J 1987 Insulin action in aging man: evidence for tissue-specific differences at low physiologic insulin levels. J Gerontol 42:196-201
33. Meneilly GS, Ryan AS, Veldhuis JD, Elahi D 1997 Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals. J Clin Endocrinol Metab 82:4088-4093
34. Meneilly GS, Ryan AS, Minaker KL, Elahi D 1998 The effect of age and glycemic level on the response of the β-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. J Clin Endocrinol Metab 83:2925-2932
35. Meneilly G, Veldhuis J, Elahi D 1999 Disruption of the pulsatile and entropie modes of insulin release during an unvarying glucose stimulus in elderly individuals. J Clin Endocrinol Metab 84:1938-1943
36. Meneilly G, McIntosh CHS, Pederson R et al 2001a Glucagon-like peptide-1 (7-37) augments insulin release in elderly patients with diabetes. Diabetes Care 24:964-965
37. Meneilly GS, McIntosh CHS, Pederson RA et al 2001b Effect of glucagon-like peptide-1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes. Diabetes Care, in press
38. Meneilly G, Egan J, Greig N, Veldhuis J, Habener J, Elahi D 2001c Twelve Weeks of Continuous Administration of GLP-1 in Elderly Diabetic Patients. Diabetologia 44:910A
39. Mojsov S, Heinrich G, Wilson I, Ravazzola M, Orci L, Habener J 1986 Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 261:11880-11889
40. Natali A, Toschi E, Camastra S, Gastaldelli A, Groop L, Ferrannini E 2000 Determinants of postabsorptive endogenous glucose output in non-diabetic subjects. European group for the study of insulin resistance (EGIR). Diabetologia 43:1266-1272
41. Nathan D, Schreiber E, Fogel H, Mojsov S, Habener J 1992 Insulinotropic action of glucagonlike peptide-I (7-37) in diabetic and nondiabetic subjects. Diabetes Care 15: 270-276
42. National Diabetes Data Group 1979 Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057
43. Pacini G, Valerio A, Beccaro F, Nosadini R, Cobelli C, Crepaldi G 1988 Insulin sensitivity and beta-cell responsivity are not decreased in elderly subjects with normal OGTT. J Am Geriatr Soc 36:317-323
44. Paolisso G, Gambardella A, Ammendola S et al 1996 Glucose tolerance and insulin action in healthy centenarians. Am J Physiol 33:E890-E894
45. Perley M, Kipnis D 1967 Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 46:1954-1962
46. Pimenta W, Korytkowski M, Mitrakou A et al 1995 Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose tolerant individuals with a first-degree NIDDM relative. JAMA 273: 1855-1861
47. Porksen N, Munn S, Steer J, Vore S, Veldhuis J, Butler P 1995 Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting. Am J Physiol 269:E478-E488
48. Reaven G 1988 Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes 37:1595-1607
49. Reaven G, Chen N, Hollenbeck C, Chen YD 1989 Effect of age on glucose tolerance and glucose uptake in healthy individuals. J Am Geriatr Soc 37:735-740
50. Rizza RA, Mandarino LJ, Gerich JE 1981 Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol 240:E630-E639
51. Rosenthal M, McMahan CA, Stern MP et al 1985 Evidence of bimodality of two hour plasma glucose concentrations in Mexican Americans: results from the San Antonio Heart Study. J Chronic Dis 38:5-16
52. Rowe J, Minaker K, Pallota J, Flier J 1983 Characterization of the insulin resistance of aging. J Clin Invest 71:1581-1587
53. Ryan A, Elahi D 1996 The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity, and age in women. J Clin Endocrinol Metab 81:4433-4438
54. Ryan AS, Egan JM, Habener JF, Elahi D 1998 Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia. J Clin Endocrinol Metab 83:2399-2404
55. Ryan A, Muller D, Elahi D 2001 Sequential hyperglycemic-euglycemic clamp to assess β-cell and peripheral tissue: studies in female athletes. J Appl Physiol 91:872-881
56. Shimokata H, Muller DC, Fleg JL, Sorkin J, Ziemba AW, Andres R 1991 Age as an independent determinant of glucose tolerance. Diabetes 40:44-51
57. Stout RW 1990 Insulin and atheroma. Diabetes Care 13:631-654
58. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus 1997 Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20:1183-1197
59. Weir GC, Mojsov S, Hendrick GK, Habener JF 1989 Glucagonlike peptide I (7-37) actions on endocrine pancreas. Diabetes 38:338-342
60. WHO 1985 Diabetes mellitus. World Health Organization, Geneva (Technical Report Series 727)
61. WHO 1999 Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO consultation, part 1: Diagnosis and classification of diabetes mellitus. World Health Organization, Geneva
62. Zamboni M, Armellini F, Harris T et al 1997 Effects of age on body fat distribution and cardiovascular risk factors in women. Am J Clin Nutr 66:111-115
63. Zavaroni I, Dall'Aglio E, Bruschi F et al 1986 Effect of age and environmental factors on glucose tolerance and insulin secretion in a worker population. J Am Geriatr Soc 34:271-275
64. Zimmet P, Whitehouse S 1978 Bimodality of fasting and two-hour glucose tolerance distributions in a Micronesian population. Diabetes 27:793-800