Signalling pathways involved in the stimulation of glycogen synthesis by insulin in rat hepatocytes

Diabetologia

Volumn 41, Issue 1, 1998, Pages 16-25

  Peak, M ^a   Rochford, J J ^a   Borthwick, A C ^a   Yeaman, S J ^a   Agius, L ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Epidermal growth factor; Glycogen synthesis; Hepatocytes (rat); Insulin; Protein kinases

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; EPIDERMAL GROWTH FACTOR; GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN BASIC PROTEIN; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; RAPAMYCIN; SODIUM CHLORIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GLYCOGEN SYNTHESIS; HORMONAL REGULATION; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FLAVONOIDS; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; INSULIN; LIVER; LIVER GLYCOGEN; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASES; RATS; RATS, WISTAR; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION;

EID: 0031930092     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050861     Document Type: Article

References (38)

1. Stalmans W, Bollen M, Mvumbi L (1987) Control of glycogen synthesis in health and disease. Diabet/Metab Rev 3: 127-161
2. Agius L, Peak M, Alberti KGMM (1990) Regulation of glycogen synthesis from glucose and gluconeogenic precursors by insulin in periportal and perivenous rat hepatocytes. Biochem J 266: 91-102
3. Agius L, Tosh D, Peak M (1993) The contribution of pyruvate cycling to loss of [6-3H]glucose during conversion of glucose to glycogen in hepatocytes: effects of insulin, glucose and acinar origin of hepatocytes. Biochem J 289: 255-262
4. Tosh D, Beresford GW, Agius L (1994) Glycogen synthesis from glucose by direct and indirect pathways in hepatocyte cultures from different nutritional states. Biochim Biophys Acta 1224: 205-212
5. Van de Werve G, Sestoft L, Folke M, Kristensen LO (1984) The onset of liver glycogen synthesis in fasted-refed rats. Effects of streptozocin diabetes and of peripheral insulin replacement. Diabetes 33: 944-949
6. Peak M, Agius L (1992) Transforming growth factor alpha inhibits glycogen synthesis and counteracts the stimulation by insulin in hepatocytes. Biochem Biophys Res Commun 183: 560-565
7. Moule SK, Edgell NJ, Welsh GI et al. (1995) Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells. Biochem J 311: 595-601
8. Sakaue J, Hara K, Noguchi T (1995) Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells. J Biol Chem 270: 11304-11309
9. Hurel SJ, Rochford JJ, Borthwick AC et al. (1996) Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesis. Biochem J 320: 871-877
10. Shepherd PR, Navé BT, Siddle K (1995) Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase Biochem J 305: 25-28
11. Azpiazu I, Saltiel AR, DePaoli-Roach A, Lawrence JC Jr (1996) Regulation of both glycogen synthase and PHAS-1 in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways. J Biol Chem 271: 5033-5039
12. Dent P, Lavoinne A, Nakielny S, Caudwell FB, Watt P, Cohen P (1990) The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature 348: 302-308
13. Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase 3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem J 296: 15-19
14. Tobe K, Kadowaki T, Hara K et al. (1992) Sequential activation of MAP kinase activator, MAP kinases and S6 peptide kinase in intact rat liver following insulin injection. J Biol Chem 267: 21089-21097
15. Lazar DF, Wiese RJ, Brady MJ et al. (1995) Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem 270: 20801-20807
16. Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789
17. Chowdhury MH, Agius L (1987) Epidermal growth factor counteracts the glycogenic effect of insulin in parenchymal hepatocyte cultures. Biochem J 247: 307-314
18. Peak M, Agius L (1994) Inhibition of glycogen synthesis by epidermal growth factor in hepatocytes. The role of cell density and pertussis toxin-sensitive GTP-binding proteins. Eur J Biochem 221: 529-536
19. Welsh GI, Foulstone EJ, Young SW, Tavaré JM, Proud CG (1994) Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem J 303: 15-20
20. Stokoe D, Caudwell B, Cohen PTW, Cohen P (1993) The substrate specificity of mitogen-activated protein (MAP) kinase-activated protein kinase-2. Biochem J 296: 843-849
21. Kyriakis JM, App H, Zhang X et al. (1992) Raf-1 activates MAP kinase-kinase. Nature 258: 417-421
22. Anderson NG, Maller JL, Tonks NK, Sturgill TW (1990) Requirement for intergration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature 343: 651-653
23. Doporé F, Vanstapel F, Stalmans W (1980) Glycogen synthase phosphatase activity in rat liver. Two protein components and their requirement for the activation of different types of substrate. Eur J Biochem 104: 137-146
24. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR (1996) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489-27494
25. Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J (1994) PDGF- and insulin-dependent pp70(S6k) activation mediated by phosphatidylinositol-3-OH kinase. Nature 370: 71-75
26. Weng QP, Andrabi K, Klippel A, Kozlowski MT, Williams RT, Avruch J (1995) Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc Natl Acad Sci USA 92: 5744-5748
27. Cross DAE, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P (1994) The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem J 303: 21-26
28. Alessi DR, Andjelkovic M, Caudwell B et al. (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO 15: 6541-6551
29. Howell SR, Hazelton GA, Klassen CD (1986) Depletion of hepatic UDP-glucuronic acid by drugs that are glucuronidated. J Pharmacol Exp Therap 236: 610-614
30. Lawrence JC Jr, Roach PJ (1997) New insights into the role and mechanism of glycogen synthase activation by insulin. Diabetes 46: 541-547
31. Eldar-Finkelman H, Argast GM, Foord O, Fischer EH, Krebs EG (1996) Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells. Proc Natl Acad Sci USA 93: 10228-10233
32. Yang L, Camoratto AM, Baffy G, Raj S, Manning DR, Williamson JR (1993) Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes. J Biol Chem 268:3739-3746
33. Alessi DR, Cauldwell FB, Andjelkovic M, Hemings BA, Cohen P (1996) Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett 399: 333-338
34. Moxham CM, Tabrizchi A, Davis RJ, Malbon CC (1996) jun N-terminal kinase mediates activation of skeletal muscle glycogen synthase by insulin in vivo. J Biol Chem 271: 30765-30773
35. Baquet A, Hue L, Meijer AJ, van Woerkom GM, Plomp PJ (1990) Swelling of rat hepatocytes stimulates glycogen synthesis. J Biol Chem 265: 955-959
36. Al-Habori M, Peak M, Thomas TH, Agius L (1992) The role of cell swelling in the stimulation of glycogen synthesis by insulin. Biochem J 282: 789-796
37. Peak M, Al-Habori M, Agius L (1992) Regulation of glycogen synthesis and glycolysis by insulin, pH and cell volume. Biochem J 282: 797-805
38. Krause U, Rider MH, Hue L (1996) Protein kinase signaling pathway triggered by cell swelling and involved in the activation of glycogen synthase and acetyl-CoA carboxylase in isolated rat hepatocytes. J Biol Chem 271: 16668-16673