Ribozyme catalysis via orbital steering

Journal of Molecular Biology

Volumn 311, Issue 5, 2001, Pages 989-999

  Scott, William G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Catalytic RNA; Enzyme catalysis; Hammerhead RNA; Orbital steering; Ribozyme

Indexed keywords

HYDROGEN; OXYGEN; PHOSPHATE; RIBOSE; RIBOZYME; RNA;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; HYDROGEN BOND; PRIORITY JOURNAL;

EID: 0035979761     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4886     Document Type: Article

References (44)

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5. Three-dimensional structure of a hammerhead ribozyme
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7. Capturing the structure of a catalytic RNA intermediate: The hammerhead ribozyme
8. Relationship between internucleotide linkage geometry and the stability of RNA
9. The structural basis of hammerhead ribozyme self-cleavage
10. Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction
11. A source for the special catalytic power of enzymes: Orbital steering
12. Theoretical aspects of orbital steering
13. Orbital steering in the catalytic power of enzymes: Small structural changes with large catalytic consequences
14. Conventional and time-resolved ribozyme X-ray crystallography
15. Stereochemistry of nucleic acids and their constituents. IV. Allowed and preferred conformations of nucleosides, nucleoside mono-, dj-, tri-, tetraphosphates, nucleic acids and polynucleotides
16. Conformational structure of polynucleotides around the O-P bonds: Refined parameters for CPF calculations
17. Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation
18. A core folding model for catalysis by the hammerhead ribozyme accounts for its extraordinary sensitivity to abasic mutations
19. Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb(III)
20. Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effects of a cleavage site phosphorothioate
21. Does a single metal ion bridge the A9 and scissile phosphates in the catalytically active hammerhead ribozyme structure?
22. Proximity, entropy and orbital steering
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24. Views on approximation, orbital steering, and enzymatic and model reactions
25. Significance of molecular alignment and orbital steering in mechanisms for enzymatic catalysis
26. Entropic rate accelerations and orbital steering
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28. "Orbital steering", entropy, and rate accelerations
29. Transition state structure of arginine kinase: Implications for catalysis of bimolecular reactions
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31. How do imidazole groups catalyze the cleavage of RNA in enzyme models and in enzymes? Evidence from "negative catalysis"
32. Title
33. Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism
34. Role of divalent metal ions in the hammerhead RNA cleavage reaction
35. The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone
36. Crystal structure of a hepatitis delta virus ribozyme
37. Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme
38. General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
39. The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution
40. The structural basis of ribosome activity in peptide bond synthesis
41. Unusual resistance of peptidyl transferase to protein extraction procedures
42. A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center
43. Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis