Myc antagonises Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway

Journal of Biological Chemistry

Volumn 280, Issue 2, 2005, Pages 1112-1122

  Vaqué, Jose P ^a   Navascues, Joaquin ^a   Shiio, Yuzuru ^b   Laiho, Marikki ^c   Ajenjo, Nuria ^a   Mauleon, Itsaso ^a   Matallanas, David ^a,d   Crespo, Piero ^a,d   León, Javier ^a,e  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

^d CSIC   (Spain)

^e UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DATA REDUCTION; DNA; GENES; GROWTH KINETICS; PROTEINS; TUMORS;

CHRONIC MYELOID LEUKEMIA (CML); FIBROBLASTS; GROWTH INHIBITION; TRANSACTIVATION DOMAIN;

CELLS;

CHIMERIC PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MYC PROTEIN; PROTEIN P14ARF; PROTEIN P15; PROTEIN P16INK4A; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR GAL4; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; A RAF KINASE; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; HRAS PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN P21; TRANSCRIPTION FACTOR; ZBTB17 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL STRAIN K 562; CELL TRANSFORMATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DNA BINDING; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; ONCOGENE C MYC; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; UPREGULATION; CELL DIVISION; CELL NUCLEUS; CHEMISTRY; DRUG ANTAGONISM; GENETICS; LEUKEMIA; METABOLISM; MUTATION; PATHOLOGY; PROMOTER REGION; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA-BINDING PROTEINS; HELIX-LOOP-HELIX MOTIFS; HUMANS; K562 CELLS; LEUKEMIA; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS A-RAF; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS P21(RAS); SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 12544256261     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409503200     Document Type: Article

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