Apoptosis of human myeloid leukemia cells induced by an inhibitor of protein phosphatases (okadaic acid) is prevented by Bcl-2 and Bcl-X(L)

Leukemia

Volumn 11, Issue 7, 1997, Pages 940-944

  Benito, A ^a   Lerga, A ^b   Silva, M ^a   Leon, J ^b   Fernandez Luna, J L ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

Apoptosis; Bcl 2; Bcl X(L); Myeloid; Okadaic acid

Indexed keywords

GLOBIN; MESSENGER RNA; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN BCL 2; PROTEIN SERINE THREONINE KINASE; VIMENTIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN HL 60; CELL STRAIN K 562; CELL SURVIVAL; CELL VIABILITY; CHRONIC MYELOID LEUKEMIA; HUMAN; HUMAN CELL; MITOSIS INHIBITION; ONCOGENE C FOS; PRIORITY JOURNAL;

EID: 0030873361     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400699     Document Type: Article

References (11)

1. Obeid L, Linardic C, Karolak L, Hannum Y. Programmed cell death induced by ceramide. Science 1993; 259: 1769-1771.
2. Hannum YA. The sphyngomyelin cycle and the second messenger function of ceramide. J Biol Chem 1994; 269: 3125-3128.
3. Bialojan C, Takai A. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem J 1988; 6: 283-290.
4. Mumby MC, Walter G. Protein serine/threonine phosphatases: structure, regulation and functions in cell growth. Physiol Rev 1993; 73: 673-699.
5. Ohoka Y, Nakai Y, Mukai M, Iwata M. Okadaic acid inhibits glucocorticoid-induced apoptosis in T cell hybridomas at its late stage. Biochem Biophys Res Commun 1993; 197: 916-921.
6. Baxter GD, Lavin MF. Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumor lines. J Immunol 1992; 148: 1949-1954.
7. Boe R, Gjertsen BT, Vintermyr OK, Houge G, Lanotte M, Doskeland SO. The protein phosphatase inhibitor OA induced morpho-logical changes typical of apoptosis in mammalian cells. Exp Cell Res 1991; 195: 237-246.
8. Bergqvist A, Magnusson G. Apoptosis of Spodoptera frugiperda cells induced by okadaic acid is abrogated by baculovirus infection. Exp Cell Res 1994; 215: 223-227.
9. Kiguchi K et al. Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. Cell Growth Diff 1994; 5: 995-1004.
10. Meikrantz W, Gisselbrecht S, Tam SW, Schlegel R. Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci USA 1994; 91: 3754-3758.
11. Zheng B et al. Human leukemia K562 cell mutant (K562/OA200) selected for resistance to okadaic acid (protein phosphatase inhibitor) lacks protein kinase C-epsilon, exhibits multidrug resistance phenotype, and expresses drug pump P-glycoprotein. J Biol Chem 1994; 269: 12332-12338.