A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

Current Biology

Volumn 8, Issue 21, 1998, Pages 1141-1152

  Robinson, Megan J ^a   Stippec, Stephen A ^a   Goldsmith, Elizabeth ^b   White, Michael A ^a   Cobb, Melanie H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CERVUS ELAPHUS; MAMMALIA;

EID: 0032558692     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(07)00485-x     Document Type: Article

References (52)

1. Robinson MJ, Cobb MH: Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997, 9:180-186.
2. Lewis TS, Shapiro PS, Ahn NG: Signal transduction through MAP kinase cascades. Adv Cancer Res 1998, 74:49-139.
3. Brunner D, Oellers N, Szabad J, Biggs WH III, Zipursky SL, Hafen E: A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 1994, 76:875-888.
4. Robbins D, Zhen E, Owaki H, Vanderbilt CA, Ebert D, Geppert TD, Cobb MH: Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. J Biol Chem 1993, 268:5097-5106.
5. Bott CM, Thorneycroft SG, Marshall CJ: The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action. FEBS Lett 1994, 352:201-205.
6. Zhang J, Zhang F, Ebert D, Cobb MH, Goldsmith EJ: Activity of the MAP kinase ERK2 is controlled by a flexible surface loop. Structure 1995, 3:299-307.
7. Canagarajah BJ, Khoklatchev A, Cobb MH, Goldsmith EJ: Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell 1997, 90:859-869.
8. Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ: Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution. Nature 1994, 367:704-710.
9. Robinson MJ, Harkins PC, Zhang J, Baer R, Haycock JW, Cobb MH, et al:. Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5′-triphosphate. Biochemistry 1996, 35:5641-5646.
10. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR: PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995, 270:27489-27494.
11. Chen RH, Sarnecki C, Blenis J: Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 1992, 12:915-927.
12. Gonzalez FA, Seth A, Raden DL, Bowman DS, Fay FS, Davis RJ: Serum induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus. J Cell Biol 1993, 122:1089-1101.
13. Lenormand P, Sardet C, Pages G, L'Allemain G, Brunet A, Pouyssegur J: Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. J Cell Biol 1993, 122:1079-1088.
14. Reszka AA, Seger R, Diltz CD, Krebs EG, Fischer EH: Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc Natl Acad Sci USA 1995, 92:8881-8885.
15. Khoklatchev AV, Canagarajah B, Wilsbacher J, Robinson M, Atkinson M, Goldsmith E, et al:. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell 1998, 93:605-615.
16. Fukuda M, Gotoh I, Gotoh Y, Nishida E: Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal. J Biol Chem 1996, 271:20024-20028.
17. Fukuda M, Gotoh Y, Nishida E: Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J 1997, 16:1901-1908.
18. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, et al.: Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 1994, 265:966-970.
19. Mansour SJ, Candia JM, Matsuura JE, Manning MC, Ahn NG: Interdependent domains controlling the enzymatic activity of mitogen-activated protein kinase kinase 1. Biochemistry 1996, 35:15529-15536.
20. Janknecht R, Ernst WH, Pingoud V, Nordheim A: Activation of ternary complex factor ELK-1 by MAP kinases. EMBO J 1993, 12:5097-5104.
21. Janknecht R, Ernst WH, Nordheim A: Sap1a is a nuclear target of signalling cascades involving ERKs. Oncogene 1995, 10:1209-1216.
22. Gille H, Kortenjann M, Thomae O, Moomaw C, Slaughter C, Cobb MH, et al.: ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J1995, 14:951-962.
23. Price MA, Rogers AE, Treisman R: Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2. EMBO J 1995, 14:2589-2601.
24. Strahl T, Gille H, Shaw PE: Selective response of ternary complex factor Sap-1a to different mitogen-activated protein kinase subgroups. Proc Natl Acad Sci USA 1996, 93:11563-11568.
25. Greene LA, Tischler AS: Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 1976, 73:2424-2428.
26. Marshall CJ: Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995, 80:179-185.
27. Fukuda M, Gotoh Y, Tachibana T, Dell K, Hattori S, Yoneda Y, et al.: Induction of neurite outgrowth by MAP kinase in PC12 cells. Oncogene 1994, 11:239-244.
28. Bar-Sagi D, Feramisco JR: Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 1985, 42:841-848.
29. Fiore RS, Bayer VE, Pelech SL, Posada J, Cooper JA, Baraban JM: p42 mitogen-activated protein kinase in brain: prominent localization in neuronal cell bodies and dendrites. Neuroscience 1993, 55:463-472.
30. Vojtek AB, Hollenberg SM, Cooper JA: Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 1993, 74:205-214.
31. White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, et al.: Multiple Ras functions can contribute to mammalian cell transformation. Cell 1995, 80:533-541.
32. Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, et al.: Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 1997, 89:457-467.
33. Heasley LE, Storey B, Fanger GR, Butterfield L, Zamarripa J, Blumberg D, et al.: GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases. Mol Cell Biol 1996, 16:648-656.
34. Daniels RH, Hall PS, Bokoch GM: Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J 1998, 17:754-764.
35. Peng X, Greene LA, Kaplan DR, Stephens RM: Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis. Neuron 1995, 15:395-406.
36. Iwasaki S, Hattori A, Sato M, Tsujimoto M, Kohno M: Characterization of the bone morphogenetic protein-2 as a neurotrophic factor. J Biol Chem 1996, 271:17360-17365.
37. Vaillancourt RR, Heasley LE, Zamarripa J, Storey B, Valius M, Kazlauskas A, et al.: Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Mol Cell Biol 1995, 15:3644-3653.
38. Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, et al.: Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 1997, 16:6426-6438.
39. Kanemitsu MY, Lau AF: Epidermal growth factor stimulates the disruption of gap junction communication and connexin43 phosphorylation independent of 12-O-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase. Mol Biol Cell 1993, 4:837-848.
40. Warn-Cramer BJ, Lampe PD, Kurata WE, Kanemitsu MY, Loo LW, Eckhart W, et al.: Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem 1996, 271:3779-3786.
41. Ray LB, Sturgill TW: Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc Natl Acad Sci USA 1987, 84:1502-1506.
42. Drewes G, Lichtenberg-Kraag B, Doring F, Mandelkow EM, Biernat J, Goris J, et al.: Mitogen-activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J 1992, 11:2131-2138.
43. Shemanko CS, Sanghera JS, Milner RE, Pelech S, Michalak M: Phosphorylation of the carboxyl terminal region of dystrophin by mitogen-activated protein (MAP) kinase. Mol Cell Biochem 1995, 152:63-70.
44. Troppmair J, Bruder JT, Munoz H, Lloyd PA, Kyriakis J, Banerjee P, et al.: Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J Biol Chem 1994, 269:7030-7035.
45. Okazaki K, Sagata N: MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos. Oncogene 1995, 10:1149-1157.
46. Khosravi-Far R, Solski PA, Clark GJ, Kinch MS, Der CJ: Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol 1995, 15:6443-6453.
47. Qui RG, Chen J, Kirn D, McCormick F, Symons M: An essential role for Rac in Ras transformation. Nature 1995, 374:457-459.
48. Sibbesen O, De Voss JJ, Ortiz de Montellano PR: Putidaredoxin reductase-putidaredoxin-cytochrome P450cam triple fusion protein: construction of a self-sufficient Escherichia coli catalytic system. J Biol Chem 1996, 271:22462-22469.
49. Medici R, Bianchi E, Di Segni G, Tocchini-Valentini GP: Efficient signal transduction by a chimeric yeast-mammalian G protein α subunit Gpa1-Gsα covalently fused to the yeast receptor Ste2. EMBO J 1997, 16:7241-7249.
50. i1α fusion protein. Biochem J 1997, 325:17-21.
51. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
52. Whitehurst CE, Boulton TG, Cobb MH, Geppert TD: Extracellular signal-regulated kinases in T cells: anti-CD3 and 4-phorbol 12-myristate 13-acetate-induced phosphorylation and activation. J Immunol 1992, 148:3230-3237.