Ras induces p21(Cip1/Waf1) cyclin kinase inhibitor transcriptionally through Sp1-binding sites

Oncogene

Volumn 18, Issue 46, 1999, Pages 6252-6261

  Kivinen, Laura ^a   Tsubari, Minna ^a   Haapajärvi, Tarja ^a   Datto, Michael B ^b   Wang, Xiao Fan ^b   Laiho, Marikki ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

p21(Cip Waf1); Ras; Transcriptional activation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; GROWTH FACTOR; GROWTH INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; OLIGONUCLEOTIDE; PROTEIN P21; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR SP1; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CDK2 PROTEIN, MOUSE; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; DNA; FLAVONOID; HYBRID PROTEIN; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOSOL; ELECTROPHORETIC MOBILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; CELL STRAIN 3T3; CELL STRAIN COS1; CERCOPITHECUS; DRUG EFFECT; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYSIOLOGY; REGULATORY SEQUENCE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

3T3 CELLS; ANIMALS; BINDING SITES; CDC2-CDC28 KINASES; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA; FLAVONOIDS; GENE EXPRESSION REGULATION; MAP KINASE SIGNALING SYSTEM; MICE; MUTAGENESIS, SITE-DIRECTED; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 0033523778     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203000     Document Type: Article

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