Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 20, 2003, Pages 4463-4478

  Masubuchi, Miyako ^a   Ebiike, Hirosato ^a   Kawasaki, Ken Ichi ^a   Sogabe, Satoshi ^a   Morikami, Kenji ^a   Shiratori, Yasuhiko ^a   Tsujii, Shinji ^a   Fujii, Toshihiko ^a   Sakata, Kiyoaki ^a   Hayase, Michiko ^a   Shindoh, Hidetoshi ^a   Aoki, Yuko ^a   Ohtsuka, Tatsuo ^a,b   Shimma, Nobuo ^a  

^a Chugai Pharmaceuticals Co Ltd   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 4 (3 PHENYLAMINOPROPOXY)BENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 3 METHYL 4 (3 PIPERIDIN 1 YLPROPOXY)BENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 3 METHYL 4 OXIRANYLMETHOXYBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 3 METHYL 4 [3 (PYRIDIN 3 YLMETHOXY)PROPOXY]BENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 3 METHYL 4 [3 [(PYRIDIN 2 YLMETHYL)AMINO]PROPOXY]BENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 3 METHYL 4 [3 [(PYRIDIN 3 YLMETHYL)AMINO]PROPOXY]BENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 3 METHYL 4 [3 [(PYRIDIN 4 YLMETHYL)AMINO]PROPOXY]BENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 3 METHYL 4 [3 [2 (PYRIDIN 3 YLETHYL)AMINO]PROPOXY]BENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 4 (2 TERT BUTYLAMINOETHOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 4 (3 AMINOPROPOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 4 (3 BENZYLAMINOPROPOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 4 (3 BROMOPROPOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 4 (3 ISOPROPYLAMINOPROPOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 4 (3 TERT BUTYLAMINOPROPOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 4 (4 TERT BUTYLAMINOBUTOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 4 (5 TERT BUTYLAMINOPENTYLOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 4 (TERT BUTYLAMINO 2 HYDROXYPROPOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; ANTIFUNGAL AGENT; BENZOFURAN DERIVATIVE; FUNGAL PROTEIN; PROTEIN INHIBITOR; PROTEIN N MYRISTOYLTRANSFERASE; RO 094609; RO 094879; UNCLASSIFIED DRUG; UNINDEXED DRUG; [3 (3 METHYL 2 PHENOXYMETHYLBENZOFURAN 4 YLOXY)PROPYL]PYRIDIN 3 YLMETHYLAMINE; [3 METHYL 4 [3 [(PYRIDIN 3 YLMETHYL)AMINO]PROPOXY]BENZOFURAN 2 YL]METHANOL; [3 [2 (2 FLUOROPHENOXYMETHYL) 3 METHYLBENZOFURAN 4 YLOXY]PROPYL]PYRIDIN 3 YLMETHYLAMINE; [3 [2 (2,3,4 TRIFLUOROPHENOXYMETHYL) 3 METHYLBENZOFURAN 4 YLOXY]PROPYL]PYRIDIN 3 YLMETHYLAMINE; [3 [2 (3 FLUOROPHENOXYMETHYL) 3 METHYLBENZOFURAN 4 YLOXY]PROPYL]PYRIDIN 3 YLMETHYLAMINE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; COMPUTER AIDED DESIGN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CANDIDA; CANDIDA ALBICANS;

EID: 12444338848     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00429-2     Document Type: Article

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