Cassette dosing approach and quantitative structure-pharmacokinetic relationship study of antifungal N-myristoyltransferase inhibitors

Journal of Chemical Information and Computer Sciences

Volumn 42, Issue 4, 2002, Pages 968-975

  Hasegawa, Kiyoshi ^a   Shindoh, Hidetoshi ^a   Shiratori, Yasuhiko ^a   Ohtsuka, Tatsuo ^a   Aoki, Yuko ^a   Ichihara, Shigeyasu ^a   Horii, Ikuo ^a   Shimma, Nobuo ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LINEAR REGRESSION;

CHEMICAL BONDS; DERIVATIVES; ENZYME INHIBITION; IONIZATION; KETONES; MOLECULAR STRUCTURE; OPTIMIZATION; SYNTHESIS (CHEMICAL);

PHARMACOKINETICS;

ACYLTRANSFERASE; ANTIFUNGAL AGENT; BENZOFURAN DERIVATIVE; ENZYME INHIBITOR; GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE; PROTEIN N MYRISTOYLTRANSFERASE;

ANIMAL; ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG DESIGN; FISCHER 344 RAT; MALE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

ACYLTRANSFERASES; ANIMALS; ANTIFUNGAL AGENTS; BENZOFURANS; COMPUTER SIMULATION; DRUG DESIGN; ENZYME INHIBITORS; MALE; MODELS, CHEMICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, INBRED F344;

EID: 0036628568     PISSN: 00952338     EISSN: None     Source Type: Journal    
DOI: 10.1021/ci0102517     Document Type: Article

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