Synthesis and antifungal activities of novel 1,3-β-D-glucan synthase inhibitors. Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 3, 2001, Pages 395-398

  Masubuchi, Kazunao ^a   Okada, Takehiro ^a   Kohchi, Masami ^a   Sakaitani, Masahiro ^a   Mizuguchi, Eisaku ^a   Shirai, Haruyoshi ^a   Aoki, Masahiro ^a   Watanabe, Takahide ^a   Kondoh, Osamu ^a   Yamazaki, Toshikazu ^a   Satoh, Yasuko ^a   Kobayashi, Kazuko ^a   Inoue, Tomoaki ^a   Horii, Ikuo ^a   Shimma, Nobuo ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BETA GLUCAN SYNTHASE; 1,3 BETA GLUCAN SYNTHASE INHIBITOR; ENZYME INHIBITOR; ETHYLAMINE; FR 901469; FUNGICIDE; LACTONE DERIVATIVE; LIPOPEPTIDE; MACROCYCLIC COMPOUND; MACROCYCLIC LIPOPEPTIDOLACTONE; N,N BIS(2 AMINOETHYL) DERIVATIVE; ORNITHINE DERIVATIVE; RO 09 3655; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDIASIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; LIVER TOXICITY; MOUSE; NONHUMAN;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTIFUNGAL; CANDIDA ALBICANS; CANDIDIASIS; COMBINATORIAL CHEMISTRY TECHNIQUES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GLUCOSYLTRANSFERASES; INCLUSION BODIES; INHIBITORY CONCENTRATION 50; LACTONES; LIVER; MEMBRANE PROTEINS; MICE; MICROBIAL SENSITIVITY TESTS; PEPTIDES; SCHIZOSACCHAROMYCES POMBE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SURVIVAL RATE; THERAPEUTIC EQUIVALENCY;

EID: 0035847660     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00678-8     Document Type: Article

References (14)