Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitos of Candida albicans myristoylCoA:protein N- myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity

Journal of Medicinal Chemistry

Volumn 40, Issue 16, 1997, Pages 2609-2625

  Devadas, Balekudru ^a   Freeman, Sandra K ^a   Zupec, Mark E ^a   Lu, Hwang Fun ^a   Nagarajan, Srinivasan R ^a   Kishore, Nandini S ^a   Lodge, Jennifer K ^a   Kuneman, David W ^a   McWherter, Charles A ^a   Vinjamoori, Dutt V ^a   Getman, Daniel P ^a   Gordon, Jeffrey I ^a   Sikorski, James A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; IMIDAZOLE DERIVATIVE; PEPTIDE;

AMINO TERMINAL SEQUENCE; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CARBOXY TERMINAL SEQUENCE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; IMMUNE DEFICIENCY; PROTEIN ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ACYLTRANSFERASES; AMIDES; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; KINETICS; MODELS, CHEMICAL; MOLECULAR MIMICRY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15144355281     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970094w     Document Type: Article

References (30)

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