A chiral recognition element with an unusual size constraint affects the potency and selectivity for peptidomimetic inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 16, 1996, Pages 1977-1982

  Devadas, Balekudru ^a   Freeman, Sandra K ^a   McWherter, Charles A ^a   Kuneman, David W ^b   Vinjamoori, Dutt V ^b   Sikorski, James A ^a  

^a PFIZER INC   (United States)

^b MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ACYLTRANSFERASE INHIBITOR; DIPEPTIDE; ENZYME INHIBITOR;

ARTICLE; CANDIDA ALBICANS; CHIRALITY; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

CANDIDA; CANDIDA ALBICANS;

EID: 0030594977     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00354-X     Document Type: Article

References (14)

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10. 10. McWherter, C. A.; Rocque, W. J.; Freeman, S. K.; Zupec, M. Z.; Gordon, J. I. unpublished results.
11. 11. All new compounds exhibited spectral and analytical data consistent with the structure.
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13. +) 611.4285, found 611.4254.
14. 14. These were synthesized by reacting either (R) or (S)-2-phenylpropionic acids with the amine 5 using DCC/HOBt, treating the resulting compounds with TFA, followed by reverse-phase HPLC purification.