N-Myristoylation of Arf proteins in Candida albicans: An in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: Protein N-myristoyltransferase

Microbiology

Volumn 143, Issue 2, 1997, Pages 357-366

  Lodge, Jennifer K ^a   Jackson Machelski, Emily ^a   Devadas, Balekudru ^b   Zupec, Mark E ^b   Getman, Daniel P ^b   Kishore, Nandini ^b   Freeman, Sandra K ^b   McWherter, Charles A ^b   Sikorski, James A ^b   Gordon, Jeffrey I ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

ADP ribosylation factors; Antifungal agents; Candida albicans; Protein N myristoylation; Saccharomyces cerevisiae

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ANTIFUNGAL AGENT; COENZYME A; FUNGAL PROTEIN; GLUCOSE; GLYCINE; MYRISTIC ACID; PEPTONE; TRANSFERASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CANDIDA ALBICANS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FUNGICIDAL ACTIVITY; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; SACCHAROMYCES CEREVISIAE;

CANDIDA ALBICANS; SACCHAROMYCES CEREVISIAE;

EID: 0031043522     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-143-2-357     Document Type: Article

References (26)

1. Barnes, W. M. (1994). PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates. Proc Natl Acad Sci USA 91, 2216-2220.
2. Bhatnagar, R. S., Jackson-Machelski, E., McWherter, C. A. & Gordon, J. I. (1994). Isothermal titration calorimetric studies of Saccharomyces cerevisiae myristoylCoA: protein N-myristoyltransferase: determinants of binding energy and catalytic discrimination among acyl-CoA and peptide ligands. J Biol Chem 269, 11045-11053.
3. Chow, M. & Moscufo, N. (1995). Myristoyl modification of viral proteins: assays to assess functional roles. Methods Enzymol 250, 495-509.
4. Denich, K. T., Malloy, P. J. & Feldman, D. (1992). Cloning and characterization of the gene encoding the ADP-ribosylation factor in Candida albicans. Gene 110, 123-128.
5. Devadas, B., Zupec, M. E., Freeman, S. K., Brown, D. L., Nagarajan, S., Sikorski, J. A., McWherter, C. A., Getman, D. P. & Gordon, J. I. (1995). Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA: protein N-myristoyltransferase. J Med Chem 38, 1837-1840.
6. Devadas, B., Freeman, S. K., McWherter, C. A., Kuneman, D. W., Vinjamoori, D. V. & Sikorski, J. A. (1996). A chiral recognition element with an unusual size constraint affects the potency & selectivity for peptidomimetic inhibitors of Candida albicans myristoyl-CoA: protein N-myristoyltransferase. Bioorg Med Chem Lett 6, 1977-1982.
7. Dohlman, H. G., Goldsmith, P., Spiegel, A. M. & Thorner, J. (1993). Pheromone action regulates G-protein α-subunit myristoylation in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA 90, 9688-9692.
8. Duronio, R. J., Rudnick, D. A., Johnson, R. L., Johnson, R. D. & Gordon, J. I. (1991). Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl-CoA: protein N-myristoyltransferase. J Cell Biol 113, 1313-1330.
9. Gietz, R. D., Schiestl, R. H., Willems, A. R. & Woods, R. A. (1995). Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast 11, 355-360.
10. Leu99→Pro, that produces temperature-sensitive myristic acid auxotrophy. J Biol Chem 268, 483-494.
11. Johnson, D. R., Bhatnagar, R. S., Knoll, L. J. & Gordon J. I. (1994a). Genetic and biochemical studies of protein N-myristoylation. Annu Rev Biochem 63, 869-914.
12. Johnson, D. R., Cok, S. J., Feldmann, H. & Gordon, J. I. (1994b). Suppressors of nmt1-181, a conditional lethal allele of the Saccharomyces cerevisiae myristoylCoA: protein N-myristoyltransferase gene, reveal proteins involved in regulating protein N-myristoylation. Proc Natl Acad Sci USA 91, 10158-10162.
13. Kahn, R. A., Clark, J., Rulka, C., Stearns, T., Zhang, C., Randazzo, P.A., Terui, T. & Cavenagh, M. (1995). Mutational analysis of Saccharomyces cerevisiae ARF1. J Biol Chem 270, 143-150.
14. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
15. Langner, C. A., Lodge, J. K., Travis, S. J., Caldwell, J. E., Lu, T., Li, Q., Bryant, M. L., Devadas, B., Gokel, G. W., Kobayashi, G. S. & Gordon, J. I. (1992). 4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. J Biol Chem 267, 17159-17169.
16. Lee, F. S., Stevens, L. A., Kao, Y. L., Moss, J. & Vaughan, M. (1994). Characterization of a glucose-repressible ADP-ribosylation factor 3 (ARF3) from Saccharomyces cerevisiae. J Biol Chem 269, 20931-20937.
17. Lodge, J. K., Johnson, R. L., Weinberg, R. A. & Gordon, J. I. (1994a). Comparison of myristoylCoA: protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neo-formans, Histoplasma capsulatum, and Candida albicans. J Biol Chem 269, 2996-3009.
18. Lodge, J. K., Jackson-Machelski, E., Toffaletti, D. L., Perfect, J. R. & Gordon, J. I. (1994b). Targeted gene replacement demonstrates that myristoylCoA: protein N-myristoyltransferase is essential for the viability of Cryptococcus neoformans. Proc Natl Acad Sci USA 91, 12008-12012.
19. Randazzo, A. R. & Kahn, R. A. (1995). Myristoylation and ADP-ribosylation factor function. Methods Enzymol 250, 394-405.
20. Rocque, W. J., McWherter, C. A., Wood, D. C. & Gordon, J. I. (1993). A comparative analysis of the kinetic mechanism and peptide substrate specificity of human and Saccharomyces cerevisiae myristoylCoA: protein N-myristoyltransferase. J Biol Chem 268, 9964-9971.
21. Rudnick, D. A., McWherter, C. A., Rocque, W. J., Lennon, P. J., Getman, D. P. & Gordon, J. I. (1991). Kinetic and structural evidence for a sequential ordered bi bi mechanism of catalysis by S. cerevisiae myristoyl-CoA: protein N-myristoyltransferase. J Biol Chem 266, 9732-9739.
22. Rudnick, D. A., Duronio, R. J. & Gordon, J. I. (1992). Methods for studying myristoylCoA: protein N-myristoyltransferase. In Lipid Modification of Proteins: a Practical Approach, pp. 37-61. Edited by N. M. Hooper & A. J. Turner. Oxford: IRL Press.
23. Sadhu, C., Hoekstra, D., McEachern, M. J., Reed, S. I. & Hicks, J. B. (1992). A G-protein α subunit from asexual Candida albicans functions in the mating signal transduction pathway of Saccharomyces cerevisiae and is regulated by the al-α2 repressor. Mol Cell Biol 12, 1977-1985.
24. Stearns, T., Kahn, R. A., Botstein, D. & Hoyt, M. A. (1990). ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes. Mol Cell Biol 10, 6690-6699.
25. Weinberg, R. A., McWherter, C. A., Freeman, S. K., Wood, D. C., Gordon, J. I. & Lee, S. C. (1995). Genetic studies reveal that myristoylCoA: protein N-myristoyltransferase is an essential enzyme in Candida albicans. Mol Microbiol 16, 241-250.
26. Wiegand, R. C., Carr, C., Minnerly, J. C., Pauley, A. M., Carron, C. P., Langner, C., Duronio, R. J. & Gordon, J. I. (1992). The Candida albicans myristoylCoA: protein N-myristoyltransferase gene: isolation and expression in Saccharomyces cerevisiae and Escherichia coli. J Biol Chem 267, 8591-8598.