Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 4, 2002, Pages 607-610

  Ebiike, Hirosato ^a   Masubuchi, Miyako ^a   Liu, Pingli ^a   Kawasaki, Kenichi ^a   Sogabe, Satoshi ^a   Hayase, Michiko ^a   Fujii, Toshihiko ^a   Sakata, Kiyoaki ^a   Shindoh, Hidetoshi ^a   Shiratori, Yasuhiko ^a   Aoki, Yuko ^a   Ohtsuka, Tatsuo ^a   Shimma, Nobuo ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; BENZOFURAN DERIVATIVE; ENZYME INHIBITOR; FUNGAL ENZYME; PROTEIN N MYRISTOYLTRANSFERASE; RO 094609; UNCLASSIFIED DRUG; ACYLTRANSFERASE; GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; BINDING AFFINITY; CANDIDA ALBICANS; CANDIDIASIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; NONHUMAN; RAT; ANIMAL; AREA UNDER THE CURVE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FISCHER 344 RAT; HUMAN; MOUSE; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CANDIDA; MURINAE;

ACYLTRANSFERASES; ANIMALS; ANTIFUNGAL AGENTS; AREA UNDER CURVE; BENZOFURANS; CANDIDA ALBICANS; CANDIDIASIS; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; DRUG DESIGN; HUMANS; MICE; PROTEIN BINDING; RATS; RATS, INBRED F344; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17344386481     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00808-3     Document Type: Article

References (9)