Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 1, 2003, Pages 87-91

  Kawasaki, Ken ichi ^a   Masubuchi, Miyako ^a   Morikami, Kenji ^a   Sogabe, Satoshi ^a   Aoyama, Tsunehisa ^a   Ebiike, Hirosato ^a   Niizuma, Satoshi ^a   Hayase, Michiko ^a   Fujii, Toshihiko ^a   Sakata, Kiyoaki ^a   Shindoh, Hidetoshi ^a   Shiratori, Yasuhiko ^a   Aoki, Yuko ^a   Ohtsuka, Tatsuo ^a   Shimma, Nobuo ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ANTIFUNGAL AGENT; BENZIMIDAZOLE DERIVATIVE; BENZOFURAN DERIVATIVE; ENZYME INHIBITOR; FLUCONAZOLE; PROTEIN N MYRISTOYLTRANSFERASE; PYRIDINE DERIVATIVE; ACYLTRANSFERASE; FUNGAL PROTEIN; GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE;

ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; MOUSE; NONHUMAN; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG STABILITY; ENZYMOLOGY; IC 50; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CANDIDA ALBICANS; MURINAE;

ACYLTRANSFERASES; ANIMALS; ANTIFUNGAL AGENTS; BENZOFURANS; CANDIDA ALBICANS; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG STABILITY; ENZYME INHIBITORS; FUNGAL PROTEINS; INHIBITORY CONCENTRATION 50; MICE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17944387642     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00844-2     Document Type: Article

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