Conformationally constrained [p-(ω-aminoalkyl)phenacetyl]-L-seryl-L- lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase

Journal of Medicinal Chemistry

Volumn 40, Issue 10, 1997, Pages 1422-1438

  Nagarajan, Srinivasan R ^a   Devadas, Balekudru ^a   Zupec, Mark E ^a   Freeman, Sandra K ^a   Brown, David L ^a   Lu, Hwang Fun ^a   Mehta, Pramod P ^a   Kishore, Nandini S ^a   McWherter, Charles A ^a   Getman, Daniel P ^a   Gordon, Jeffrey I ^b   Sikorski, James A ^a  

^a MONSANTO COMPANY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(11 AMINOUNDECANOYL)SERYLLYSYL 2 CYCLOHEXYLETHYLAMIDE; (11 AMINOUNDECANOYL)SERYLLYSYLCYCLOHEXYLALANYLAMIDE; 11 AMINOUNDECANOYLSERYLLYSYLLEUCYLAMIDE; [2 [4 (6 AMINOHEXYL)PHENYL]PROPIONYL]SERYLLYSYL 2 CYCLOHEXYLETHYLAMIDE; [4 (6 AMINOHEXYL)PHENYLACETYL]SERYLLYSYL 2 CYCLOHEXYLETHYLAMIDE TRIFLUOROACETATE; ALANINE DERIVATIVE; AMIDE; CARBON; CELL PROTEIN; GLYCINE; MYRISTIC ACID; PROTEIN N MYRISTOYLTRANSFERASE; TETRAPEPTIDE; TRANSFERASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CANDIDA ALBICANS; CARBOXY TERMINAL SEQUENCE; CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACYLTRANSFERASES; AMIDES; CANDIDA ALBICANS; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 15144352323     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9608671     Document Type: Article

References (29)

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